Karl Kuban
YOU?
Author Swipe
View article: Newborn blood DNA methylation and childhood asthma: findings from the ECHO program
Newborn blood DNA methylation and childhood asthma: findings from the ECHO program Open
Background DNA methylation (DNAm) at birth has been linked to childhood asthma in epigenome-wide association studies (EWASs). However, existing EWASs have limited representation of non-European and extremely preterm participants and have n…
View article: Maternal and psychosocial antecedents of anxiety and depression in extremely low gestational age newborns at age 15 years
Maternal and psychosocial antecedents of anxiety and depression in extremely low gestational age newborns at age 15 years Open
The prevalence of many psychiatric symptoms, including anxiety and depression, is higher in individuals born extremely preterm (EP) than in term-born individuals during childhood and adolescence. In this prospective study of adolescents bo…
View article: Maternal and psychosocial antecedents of anxiety and depression in extremely low gestational age newborns at age 15 years
Maternal and psychosocial antecedents of anxiety and depression in extremely low gestational age newborns at age 15 years Open
Objectives The prevalence of many psychiatric symptoms, including anxiety and depression, is higher in individuals born extremely preterm (EP) than in term-born individuals during childhood and adolescence. In this prospective study of ado…
View article: Psychiatric Outcomes, Functioning, and Participation in Extremely Low Gestational Age Newborns at Age 15 Years
Psychiatric Outcomes, Functioning, and Participation in Extremely Low Gestational Age Newborns at Age 15 Years Open
View article: Retinopathy of prematurity and neurodevelopmental outcome and quality of life at 10 years of age
Retinopathy of prematurity and neurodevelopmental outcome and quality of life at 10 years of age Open
Objective In a cohort of 10-year-old children born extremely preterm, we evaluated the hypothesis that increasing severity of retinopathy of prematurity (ROP) is associated with increasing frequency of unfavorable neurodevelopmental and qu…
View article: Prenatal Metal Exposure Alters the Placental Proteome in a Sex-Dependent Manner in Extremely Low Gestational Age Newborns: Links to Gestational Age
Prenatal Metal Exposure Alters the Placental Proteome in a Sex-Dependent Manner in Extremely Low Gestational Age Newborns: Links to Gestational Age Open
Prenatal exposure to toxic metals is associated with altered placental function and adverse infant and child health outcomes. Adverse outcomes include those that are observed at the time of birth, such as low birthweight, as well as those …
View article: Neurodevelopmental and behavioral outcomes of very preterm infants: latent profile analysis in the Environmental influences on Child Health Outcomes (ECHO) Program
Neurodevelopmental and behavioral outcomes of very preterm infants: latent profile analysis in the Environmental influences on Child Health Outcomes (ECHO) Program Open
View article: Evaluation of pediatric epigenetic clocks across multiple tissues
Evaluation of pediatric epigenetic clocks across multiple tissues Open
Background Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination. Results Our study used data from seven tissue types …
View article: Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns
Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns Open
View article: COVID-19 Stress and Child Behavior: Examining Discrimination and Social Support in Racially Diverse ECHO Cohorts
COVID-19 Stress and Child Behavior: Examining Discrimination and Social Support in Racially Diverse ECHO Cohorts Open
View article: Perinatal Factors and Emotional, Cognitive, and Behavioral Dysregulation in Childhood and Adolescence
Perinatal Factors and Emotional, Cognitive, and Behavioral Dysregulation in Childhood and Adolescence Open
View article: A multi‐omic approach identifies an autism spectrum disorder (<scp>ASD</scp>) regulatory complex of functional epimutations in placentas from children born preterm
A multi‐omic approach identifies an autism spectrum disorder (<span>ASD</span>) regulatory complex of functional epimutations in placentas from children born preterm Open
Children born preterm are at heightened risk of neurodevelopmental impairments, including Autism Spectrum Disorder (ASD). The placenta is a key regulator of neurodevelopmental processes, though the precise underlying molecular mechanisms r…
View article: Additional file 1 of Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns
Additional file 1 of Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns Open
Additional file 1: Table S1. Provides a list of all significant CpG loci identified in the analysis presented in this manuscript.
View article: Perinatal Factors and Emotional, Cognitive, and Behavioral Dysregulation in Childhood and Adolescence
Perinatal Factors and Emotional, Cognitive, and Behavioral Dysregulation in Childhood and Adolescence Open
OBJECTIVE: This cohort study assessed perinatal factors known to be related to maternal and neonatal inflammation and hypothesized that several would be associated with emotional, cognitive, and behavioral dysregulation in youth. METHOD: T…
View article: A multi-omic approach identifies an autism spectrum disorder (ASD) regulatory complex of functional epimutations in placentas from children born preterm
A multi-omic approach identifies an autism spectrum disorder (ASD) regulatory complex of functional epimutations in placentas from children born preterm Open
Children born preterm are at heightened risk of neurodevelopmental impairments, including Autism Spectrum Disorder (ASD). The placenta is a key regulator of neurodevelopmental processes, though the precise underlying molecular mechanisms r…
View article: Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns
Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns Open
Background Health outcomes among children born prematurely are known to be sexually dimorphic, with male infants often more affected, yet the mechanism behind this observation is not clear. CpG methylation levels in the placenta and blood …
View article: Table of Contents
Table of Contents Open
View article: Analysis of Neurodevelopment in Children Born Extremely Preterm Treated With Acid Suppressants Before Age 2 Years
Analysis of Neurodevelopment in Children Born Extremely Preterm Treated With Acid Suppressants Before Age 2 Years Open
Importance Children born preterm are at increased risk of adverse neurodevelopmental outcomes and may be particularly vulnerable to the effects of gastric acid suppression during infancy. Objective To assess whether early acid suppressant …
View article: Placental transcriptional signatures associated with cerebral white matter damage in the neonate
Placental transcriptional signatures associated with cerebral white matter damage in the neonate Open
Cerebral white matter is the most common anatomic location of neonatal brain injury in preterm newborns. Factors that predispose preterm newborns to white matter damage are understudied. In relation to studies of the placenta-brain-axis, d…
View article: Association of prenatal modifiable risk factors with attention-deficit hyperactivity disorder outcomes at age 10 and 15 in an extremely low gestational age cohort
Association of prenatal modifiable risk factors with attention-deficit hyperactivity disorder outcomes at age 10 and 15 in an extremely low gestational age cohort Open
Background The increased risk of developing attention-deficit hyperactivity disorder (ADHD) in extremely preterm infants is well-documented. Better understanding of perinatal risk factors, particularly those that are modifiable, can inform…
View article: Growth During Infancy After Extremely Preterm Birth: Associations with Later Neurodevelopmental and Health Outcomes
Growth During Infancy After Extremely Preterm Birth: Associations with Later Neurodevelopmental and Health Outcomes Open
View article: The Placenta Epigenome–Brain Axis: Placental Epigenomic and Transcriptomic Responses that Preprogram Cognitive Impairment
The Placenta Epigenome–Brain Axis: Placental Epigenomic and Transcriptomic Responses that Preprogram Cognitive Impairment Open
Aim: The placenta-brain axis reflects a developmental linkage where disrupted placental function is associated with impaired neurodevelopment later in life. Placental gene expression and the expression of epigenetic modifiers such a…
View article: Trial of Erythropoietin for Hypoxic–Ischemic Encephalopathy in Newborns
Trial of Erythropoietin for Hypoxic–Ischemic Encephalopathy in Newborns Open
The administration of erythropoietin to newborns undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy did not result in a lower risk of death or neurodevelopmental impairment than placebo and was associated with a higher …
View article: CpG methylation patterns in placenta and neonatal blood are differentially associated with neonatal inflammation
CpG methylation patterns in placenta and neonatal blood are differentially associated with neonatal inflammation Open
View article: Maternal social risk, gestational age at delivery, and cognitive outcomes among adolescents born extremely preterm
Maternal social risk, gestational age at delivery, and cognitive outcomes among adolescents born extremely preterm Open
Background Children born extremely preterm (EP) are at increased risk of cognitive deficits that persist into adulthood. Few large cohort studies have examined differential impairment of cognitive function in EP‐born adolescents in relatio…
View article: Quantitative MRI Characterization of the Extremely Preterm Brain at Adolescence: Atypical versus Neurotypical Developmental Pathways
Quantitative MRI Characterization of the Extremely Preterm Brain at Adolescence: Atypical versus Neurotypical Developmental Pathways Open
Background Extremely preterm (EP) birth is associated with higher risks of perinatal white matter (WM) injury, potentially causing abnormal neurologic and neurocognitive outcomes. MRI biomarkers distinguishing individuals with and without …
View article: Innovative computational approaches shed light on genetic mechanisms underlying cognitive impairment among children born extremely preterm
Innovative computational approaches shed light on genetic mechanisms underlying cognitive impairment among children born extremely preterm Open
View article: Placental genomics mediates genetic associations with complex health traits and disease
Placental genomics mediates genetic associations with complex health traits and disease Open
As the master regulator in utero , the placenta is core to the Developmental Origins of Health and Disease (DOHaD) hypothesis but is historically understudied. To identify placental gene-trait associations (GTAs) across the life course, we…
View article: The placenta epigenome-brain axis: placental epigenomic and transcriptomic responses that preprogram cognitive impairment
The placenta epigenome-brain axis: placental epigenomic and transcriptomic responses that preprogram cognitive impairment Open
Aim: The placenta–brain axis reflects a developmental linkage where disrupted placental function is associated with impaired neurodevelopment later in life. Placental gene expression and the expression of epigenetic modifiers such as miRNA…
View article: Maternal social risk, gestational age at delivery, and cognitive outcomes among adolescents born extremely preterm
Maternal social risk, gestational age at delivery, and cognitive outcomes among adolescents born extremely preterm Open
Background: Children born extremely preterm (EP) are at increased risk of cognitive deficits that persist into adulthood. Few large cohort studies have examined differential impairment of cognitive function in EP-born adolescents in relati…