Karl Mann
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View article: Longitudinal Associations of Structural and Functional Brain Connectivity With Dimensions of Psychopathology in Adolescence
Longitudinal Associations of Structural and Functional Brain Connectivity With Dimensions of Psychopathology in Adolescence Open
These findings highlight the dynamic interplay between brain connectivity development and psychopathology in adolescence, with potential implications for identifying neural markers of risk and resilience during sensitive windows of develop…
View article: 901 Identification of Acute Pancreatitis Aetiology at the Tertiary Royal Liverpool University Hospital
901 Identification of Acute Pancreatitis Aetiology at the Tertiary Royal Liverpool University Hospital Open
Aim Accurately identifying acute pancreatitis (AP) aetiologies prevents recurrent presentations and reduces associated morbidity and mortality. This audit aimed to evaluate the Royal Liverpool University Hospital (RLUH) against NICE NG104 …
View article: Guidelines on Internet Use Disorders: Introduction and Methodology
Guidelines on Internet Use Disorders: Introduction and Methodology Open
Aim: Empirical evidence suggests that Internet Use Disorders (IUDs) can be considered as disorders due to addictive behaviors that are related to impairment and are of clinical relevance. Currently, no guidelines following a standardised m…
View article: The Impact of Role Models on Sexual Minority Women: A Qualitative Interview Study
The Impact of Role Models on Sexual Minority Women: A Qualitative Interview Study Open
Sexual minority women (e.g., lesbian, bisexual, pansexual) have increased risk of experiencing various mental health problems compared to sexual minority men and heterosexual individuals. Sexual minority women (SMW) have also been found to…
View article: Personality, Social Factors, Brain Functioning, Familial Risk, and Trajectories of Alcohol Misuse in Adolescence
Personality, Social Factors, Brain Functioning, Familial Risk, and Trajectories of Alcohol Misuse in Adolescence Open
Importance The development of an alcohol use disorder in adolescence is associated with increased risk of future alcohol dependence. The differential associations of risk factors with alcohol use over the course of 8 years are important fo…
View article: Reductions in World Health Organization Risk Drinking Level Are Associated With Reductions in Alcohol Use Disorder Diagnosis and Criteria: Evidence From an Alcohol Pharmacotherapy Trial
Reductions in World Health Organization Risk Drinking Level Are Associated With Reductions in Alcohol Use Disorder Diagnosis and Criteria: Evidence From an Alcohol Pharmacotherapy Trial Open
Objectives This study aimed to evaluate the validity of World Health Organization (WHO) risk drinking level reductions as meaningful endpoints for clinical practice and research. This study examined whether such reductions were associated …
View article: Reductions in World Health Organization risk drinking level are associated with improvements in sleep problems among individuals with alcohol use disorder
Reductions in World Health Organization risk drinking level are associated with improvements in sleep problems among individuals with alcohol use disorder Open
Aims Among individuals with alcohol use disorder (AUD), sleep disturbances are pervasive and contribute to the etiology and maintenance of AUD. However, despite increased attention toward the relationship between alcohol use and sleep, lim…
View article: Reductions in WHO risk drinking levels correlate with alcohol craving among individuals with alcohol use disorder
Reductions in WHO risk drinking levels correlate with alcohol craving among individuals with alcohol use disorder Open
Background Abstinence has historically been considered the preferred goal of alcohol use disorder (AUD) treatment. However, most individuals with AUD do not want to abstain and many are able to reduce their drinking successfully. Craving i…
View article: Nickel Content of Pineapple (Ananas comosus L.) and Banana (Musa sapientum L.) Sold in Gwagwalada Area Council, Abuja, Nigeria
Nickel Content of Pineapple (Ananas comosus L.) and Banana (Musa sapientum L.) Sold in Gwagwalada Area Council, Abuja, Nigeria Open
Nickel is a heavy metal that can accumulate in plants, potentially posing health risks to consumers if present above recommended levels The present study aimed to determine the nickel (Ni) concentrations in pineapple and banana samples and…
View article: Education and Training in Addiction Medicine and Psychology across Europe: A EUFAS Survey
Education and Training in Addiction Medicine and Psychology across Europe: A EUFAS Survey Open
Introduction: Training in addiction medicine and addiction psychology is essential to ensure the quality of treatment for patients with substance use disorders. Some earlier research has shown varying training between countries, but no com…
View article: The impact of life satisfaction in the treatment of gaming disorder and other internet use disorders: Results from a randomized controlled trial
The impact of life satisfaction in the treatment of gaming disorder and other internet use disorders: Results from a randomized controlled trial Open
Objective According to ICD-11 gaming disorder is currently defined as a behavioral addiction. While our understanding of crucial aspects of this new condition including other subtypes of internet use disorders is growing, less is known abo…
View article: The effects of nalmefene on the impulsive and reflective system in alcohol use disorder: A resting-state fMRI study
The effects of nalmefene on the impulsive and reflective system in alcohol use disorder: A resting-state fMRI study Open
Rationale Central aspects of alcohol use disorder (AUD) are the irresistible desire for alcohol and impaired control over its intake. According to the triadic neurocognitive model of addiction, this arises from aberrant functioning of diff…
View article: Reward drinking and naltrexone treatment response among young adult heavy drinkers
Reward drinking and naltrexone treatment response among young adult heavy drinkers Open
Aims Theory‐driven, exploratory study to: (i) identify a reward drinking phenotype in young adults; (ii) evaluate this phenotype as a predictor of naltrexone response; and (iii) examine mechanisms of naltrexone in reward drinkers. Design S…
View article: Genetic Contributions to Alcohol Use Disorder Treatment Outcomes: A Genome-wide Pharmacogenomics Study
Genetic Contributions to Alcohol Use Disorder Treatment Outcomes: A Genome-wide Pharmacogenomics Study Open
Naltrexone can aid in reducing alcohol consumption, while acamprosate supports abstinence; however, not all patients with alcohol use disorder (AUD) benefit from these treatments. Here we present the first genome-wide association study of …
View article: The World Health Organization Risk Drinking Levels Measure of Alcohol Consumption: Prevalence and Health Correlates in Nationally Representative Surveys of U.S. Adults, 2001–2002 and 2012–2013
The World Health Organization Risk Drinking Levels Measure of Alcohol Consumption: Prevalence and Health Correlates in Nationally Representative Surveys of U.S. Adults, 2001–2002 and 2012–2013 Open
The increase in potentially problematic drinking levels among U.S. adults emphasizes the need for better prevention and treatment strategies. The study results support the validity of the WHO risk drinking levels, which show clinical utili…
View article: Stability of Drinking Reductions and Long-term Functioning Among Patients with Alcohol Use Disorder
Stability of Drinking Reductions and Long-term Functioning Among Patients with Alcohol Use Disorder Open
Background The World Health Organization (WHO) categorizes alcohol consumption according to grams consumed into low-, medium-, high-, and very-high-risk drinking levels (RDLs). Although abstinence has been considered the ideal outcome of a…
View article: Genome-wide Association Study of Alcohol Dependence
Genome-wide Association Study of Alcohol Dependence Open
Identification of genes contributing to alcohol dependence will improve our understanding of the mechanisms underlying this disorder.
View article: Substance Use Initiation, Particularly Alcohol, in Drug-Naive Adolescents: Possible Predictors and Consequences From a Large Cohort Naturalistic Study
Substance Use Initiation, Particularly Alcohol, in Drug-Naive Adolescents: Possible Predictors and Consequences From a Large Cohort Naturalistic Study Open
These results suggest that the transition from no use to frequent drinking in early to mid-adolescence may disrupt normative developmental changes in behavioral control. In addition, blunted activity of the medial orbitofrontal cortex duri…
View article: Reduction in World Health Organization Risk Drinking Levels and Cardiovascular Disease
Reduction in World Health Organization Risk Drinking Levels and Cardiovascular Disease Open
Background Reductions in World Health Organization (WHO) risk drinking levels have recently been shown to lower the risk of multiple adverse health outcomes, but prior work has not examined reductions in WHO risk drinking levels in relatio…
View article: Which conditions should be considered as disorders in the International Classification of Diseases (ICD-11) designation of “other specified disorders due to addictive behaviors”?
Which conditions should be considered as disorders in the International Classification of Diseases (ICD-11) designation of “other specified disorders due to addictive behaviors”? Open
Background Gambling and gaming disorders have been included as “disorders due to addictive behaviors” in the International Classification of Diseases (ICD-11). Other problematic behaviors may be considered as “other specified disorders due…
View article: The IMAGEN study: a decade of imaging genetics in adolescents
The IMAGEN study: a decade of imaging genetics in adolescents Open
Imaging genetics offers the possibility of detecting associations between genotype and brain structure as well as function, with effect sizes potentially exceeding correlations between genotype and behavior. However, study results are ofte…