Karl Rouger
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View article: Multiphoton microscopy and tissue clearing for 3D characterization of the vasculature and fibrosis remodeling in rat dystrophic skeletal muscle
Multiphoton microscopy and tissue clearing for 3D characterization of the vasculature and fibrosis remodeling in rat dystrophic skeletal muscle Open
View article: Sphingolipids in Extracellular Vesicles Released From the Skeletal Muscle Plasma Membrane Control Muscle Stem Cell Fate During Muscle Regeneration
Sphingolipids in Extracellular Vesicles Released From the Skeletal Muscle Plasma Membrane Control Muscle Stem Cell Fate During Muscle Regeneration Open
Extracellular vesicles (EVs) represent a cytokine‐independent pathway though which skeletal muscle (SkM) cells influence the fate of neighbouring cells, thereby regulating SkM metabolic homeostasis and regeneration. Although SkM‐EVs are in…
View article: Multiphoton microscopy and tissue clearing for 3D characterization of the vasculature and fibrosis remodeling in rat dystrophic skeletal muscle
Multiphoton microscopy and tissue clearing for 3D characterization of the vasculature and fibrosis remodeling in rat dystrophic skeletal muscle Open
Duchenne muscular dystrophy (DMD) is characterized by repeated cycles of muscle fiber necrosis/regeneration and their progressive replacement by fibrous and adipose tissues. Vascular abnormalities are also reported as pathophysiological ha…
View article: Human muscle stem cell responses to mechanical stress into tunable 3D alginate matrices
Human muscle stem cell responses to mechanical stress into tunable 3D alginate matrices Open
View article: Développement des modèles de culture cellulaire de muscle en 3D : de nouvelles opportunités pour les productions animales
Développement des modèles de culture cellulaire de muscle en 3D : de nouvelles opportunités pour les productions animales Open
Le muscle squelettique est organisé en faisceau de fibres musculaires de différentes tailles et parcouru par des réseaux vasculaires et nerveux. Les cellules satellites sont des cellules souches logées le long des fibres musculaires et son…
View article: Specific and label-free endogenous signature of dystrophic muscle by Synchrotron deep ultraviolet radiation
Specific and label-free endogenous signature of dystrophic muscle by Synchrotron deep ultraviolet radiation Open
View article: Human MuStem cells repress T-cell proliferation and cytotoxicity through both paracrine and contact-dependent pathways
Human MuStem cells repress T-cell proliferation and cytotoxicity through both paracrine and contact-dependent pathways Open
View article: 3D in vitro models of skeletal muscle: myopshere, myobundle and bioprinted muscle construct
3D in vitro models of skeletal muscle: myopshere, myobundle and bioprinted muscle construct Open
View article: Human MuStem Cell Grafting into Infarcted Rat Heart Attenuates Adverse Tissue Remodeling and Preserves Cardiac Function
Human MuStem Cell Grafting into Infarcted Rat Heart Attenuates Adverse Tissue Remodeling and Preserves Cardiac Function Open
View article: Immunophenotype of a Rat Model of Duchenne's Disease and Demonstration of Improved Muscle Strength After Anti-CD45RC Antibody Treatment
Immunophenotype of a Rat Model of Duchenne's Disease and Demonstration of Improved Muscle Strength After Anti-CD45RC Antibody Treatment Open
Corticosteroids (CS) are standard therapy for the treatment of Duchenne's muscular dystrophy (DMD). Even though they decrease inflammation, they have limited efficacy and are associated with significant side effects. There is therefore the…
View article: FoxO3a overexpression prevents both glycogen overload and autophagic buildup in skeletal muscle of Pompe disease
FoxO3a overexpression prevents both glycogen overload and autophagic buildup in skeletal muscle of Pompe disease Open
View article: Bifeo3 Harmonic Nanoparticle (Bfo-Hnps) Use for the Stem Cell Tracking: Labeling Investigation by Non Linear Microscopy and X-Ray Fluorescence
Bifeo3 Harmonic Nanoparticle (Bfo-Hnps) Use for the Stem Cell Tracking: Labeling Investigation by Non Linear Microscopy and X-Ray Fluorescence Open
Duchenne Muscular Dystrophy is the most common form of degenerative muscle disease; currently, there is no effective treatment. In 2011, our group showed that an adult stem cell population (MuStem) isolated from healthy dog skeletal muscle…
View article: Repair of myocardial infarction with human adult muscle-derived stem cells “MuStem”
Repair of myocardial infarction with human adult muscle-derived stem cells “MuStem” Open
Repair of myocardial infarction with human adult muscle-derived stem cells “MuStem”. 6eme congrés international de Myologie
View article: Intramuscular transplantation in non-human primates of human muscle-derived stem cells (MuStem cells), a promising candidate for cell therapy of muscular dystrophies
Intramuscular transplantation in non-human primates of human muscle-derived stem cells (MuStem cells), a promising candidate for cell therapy of muscular dystrophies Open
Intramuscular transplantation in non-human primates of human muscle-derived stem cells (MuStem cells), a promising candidate for cell therapy of muscular dystrophies. 6eme congrès international de Myologie
View article: Demonstration of immunomodulatory properties for the human MuStem cell population, a promising candidate for cell therapy of muscular dystrophies
Demonstration of immunomodulatory properties for the human MuStem cell population, a promising candidate for cell therapy of muscular dystrophies Open
Immunomodulatory properties for the human MuStem cell population, a promising candidate for cell therapy of muscular dystrophies. Forum Bioregate
View article: Satellite cells fail to contribute to muscle repair but are functional in Pompe disease (glycogenosis type II)
Satellite cells fail to contribute to muscle repair but are functional in Pompe disease (glycogenosis type II) Open
View article: Demonstration of immunomodulatory properties for the human MuStem cell population, a promising candidate for cell therapy of muscular dystrophies
Demonstration of immunomodulatory properties for the human MuStem cell population, a promising candidate for cell therapy of muscular dystrophies Open
Over the last eighteen years, the identification of stem cells in adult tissue opened new opportunities in cellbased\ntherapy strategy. However, allogeneic cell transplantation protocols are highly limited by graft rejection.\nTo overcome …
View article: Immunological characterization of a rat model of Duchenne’s disease and demonstration of improved muscle strength after anti-CD45RC antibody treatment
Immunological characterization of a rat model of Duchenne’s disease and demonstration of improved muscle strength after anti-CD45RC antibody treatment Open
Duchenne muscular dystrophy (DMD) has as standard pharmacological therapy with corticoisteroids (CS) that decrease inflammation and immune responses present in patients and animal models. CS have however limited efficacy and important and …
View article: Vascular Delivery of Allogeneic MuStem Cells in Dystrophic Dogs Requires Only Short-Term Immunosuppression to Avoid Host Immunity and Generate Clinical/Tissue Benefits
Vascular Delivery of Allogeneic MuStem Cells in Dystrophic Dogs Requires Only Short-Term Immunosuppression to Avoid Host Immunity and Generate Clinical/Tissue Benefits Open
Growing demonstrations of regenerative potential for some stem cells led recently to promising therapeutic proposals for neuromuscular diseases. We have shown that allogeneic MuStem cell transplantation into Golden Retriever muscular dystr…
View article: Human serum and platelet lysate are appropriate xeno-free alternatives for clinical-grade production of human MuStem cell batches
Human serum and platelet lysate are appropriate xeno-free alternatives for clinical-grade production of human MuStem cell batches Open
View article: Multiphotonic Imaging and Bismuth Ferrite Harmonic Nanoparticles (BFO HNPs) to assess pre-clinically innovative therapeutic strategies through monitoring engraftment properties of injected cells
Multiphotonic Imaging and Bismuth Ferrite Harmonic Nanoparticles (BFO HNPs) to assess pre-clinically innovative therapeutic strategies through monitoring engraftment properties of injected cells Open
In order to assess the therapeutic potential of cell-based strategies, it is of paramount importance to elaborate and validate tools for monitoring the behavior of injected cells in terms of tissue dissemination and engraftment properties.…
View article: Myocardial infarct repair with human adult muscle-derived stem cells “MuStem”
Myocardial infarct repair with human adult muscle-derived stem cells “MuStem” Open
Myocardial infarction is a leading cause of morbidity and mortality worldwide. Although medical and surgical treatments can significantly improve patient outcomes, no treatment currently available is able to generate new contractile tissue…
View article: Additional file 5: of Human serum and platelet lysate are appropriate xeno-free alternatives for clinical-grade production of human MuStem cell batches
Additional file 5: of Human serum and platelet lysate are appropriate xeno-free alternatives for clinical-grade production of human MuStem cell batches Open
Table S5. The UMI counts for each gene in each sample normalized by dividing by the sum of UMI counts across all genes in the same sample. Normalized UMI counts expressed in UPM (UMI counts for one gene per 1,000,000 UMI counts for all gen…
View article: FoxO3a overexpression prevents both glycogen overload and autophagic buildup in Pompe disease
FoxO3a overexpression prevents both glycogen overload and autophagic buildup in Pompe disease Open
Pompe disease (glycogen storage disease type II) is a lysosomal storage disorder caused by the mutation of acid α-glucosidase (Gaa), the unique enzyme degrading glycogen in glucose into lysosomes. A massive glycogen overload is described i…
View article: Skeletal Muscle Regenerative Potential of Human MuStem Cells following Transplantation into Injured Mice Muscle
Skeletal Muscle Regenerative Potential of Human MuStem Cells following Transplantation into Injured Mice Muscle Open
View article: Pathogen reduction through additive-free short-wave UV light irradiation retains the optimal efficacy of human platelet lysate for the expansion of human bone marrow mesenchymal stem cells
Pathogen reduction through additive-free short-wave UV light irradiation retains the optimal efficacy of human platelet lysate for the expansion of human bone marrow mesenchymal stem cells Open
We demonstrated the feasibility of using UV-C-treated platelets to subsequently obtain pathogen-reduced hPL, while preserving its optimal quality and efficacy for hMSC expansion in cell therapy applications.
View article: Multi-harmonic Imaging in the Second Near-Infrared Window of Nanoparticle-Labeled Stem Cells as a Monitoring Tool in Tissue Depth
Multi-harmonic Imaging in the Second Near-Infrared Window of Nanoparticle-Labeled Stem Cells as a Monitoring Tool in Tissue Depth Open
In order to assess the therapeutic potential of cell-based strategies, it is of paramount importance to elaborate and validate tools for monitoring the behavior of injected cells in terms of tissue dissemination and engraftment properties.…
View article: Gait characterization in golden retriever muscular dystrophy dogs using linear discriminant analysis
Gait characterization in golden retriever muscular dystrophy dogs using linear discriminant analysis Open
View article: Bismuth Ferrite Harmonic Nanoparticles and Biphotonic Microscopy: Innovative Approach to Track In Vivo Muscle Stem Cells, a Promising Candidate for Cell Therapy of Muscular Dystrophy
Bismuth Ferrite Harmonic Nanoparticles and Biphotonic Microscopy: Innovative Approach to Track In Vivo Muscle Stem Cells, a Promising Candidate for Cell Therapy of Muscular Dystrophy Open
Bismuth Ferrite Harmonic Nanoparticles and Biphotonic Microscopy: Innovative Approach to Track In Vivo Muscle Stem Cells, a Promising Candidate for Cell Therapy of Muscular Dystrophy Duchenne Muscular Dystrophy (DMD) is a fatal X‐linked re…
View article: Quantitative proteome profiling of dystrophic dog skeletal muscle reveals a stabilized muscular architecture and protection against oxidative stress after systemic delivery of MuStem cells
Quantitative proteome profiling of dystrophic dog skeletal muscle reveals a stabilized muscular architecture and protection against oxidative stress after systemic delivery of MuStem cells Open
Proteomic profiling plays a decisive role in the elucidation of molecular signatures representative of a specific clinical context. MuStem cell based therapy represents a promising approach for clinical applications to cure Duchenne muscul…