Karla Mack
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View article: Space-associated stem cell hallmarks of aging and resilience in astronauts
Space-associated stem cell hallmarks of aging and resilience in astronauts Open
Previous reports revealed immune dysfunction, chromosomal abnormalities, cytokine deregulation, and telomere alterations after prolonged spaceflight. However, the stress of space on hematopoietic stem and progenitor cells (HSPCs) and the r…
View article: Accelerated Hematopoietic Stem Cell Aging in Space
Accelerated Hematopoietic Stem Cell Aging in Space Open
Stem cell aging is accelerated by macroenvironmental and microenvironmental stressors, including inflammation. Previously, the NASA Twins study revealed inflammatory cytokine upregulation, chromosomal alterations, and telomere changes sugg…