Karla Priscila Ferro
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View article: REGULAÇÃO EPIGENÉTICA E RESPOSTA ANTIOXIDANTE COMO CHAVES DA RESISTÊNCIA AO ÁCIDO GÁLICO EM KG-1
REGULAÇÃO EPIGENÉTICA E RESPOSTA ANTIOXIDANTE COMO CHAVES DA RESISTÊNCIA AO ÁCIDO GÁLICO EM KG-1 Open
View article: EFEITOS IMUNOMODULADORES DO ARTESUNATO EM UM MODELO ANIMAL DE SÍNDROME MIELODISPLÁSICA
EFEITOS IMUNOMODULADORES DO ARTESUNATO EM UM MODELO ANIMAL DE SÍNDROME MIELODISPLÁSICA Open
Introdução: A síndrome mielodisplásica (SMD) é um grupo heterogêneo de doenças da medula óssea que pode progredir para leucemia mieloide aguda. O modelo murino NUP98-HOXD13 apresenta displasia na medula óssea e extensa apoptose de precurso…
View article: Arhgap21 Deficiency Results in Increase of Osteoblastic Lineage Cells in the Murine Bone Marrow Microenvironment
Arhgap21 Deficiency Results in Increase of Osteoblastic Lineage Cells in the Murine Bone Marrow Microenvironment Open
ARHGAP21 is a member of the RhoGAP family of proteins involved in cell growth, differentiation, and adhesion. We have previously shown that the heterozygous Arhgap21 knockout mouse model (Arhgap21 +/− ) presents several alterations in the …
View article: (–)-Epigallocatechin-3-gallate induces apoptosis and differentiation in leukaemia by targeting reactive oxygen species and PIN1
(–)-Epigallocatechin-3-gallate induces apoptosis and differentiation in leukaemia by targeting reactive oxygen species and PIN1 Open
(–)-Epigallocatechin-3-gallate (EGCG), the major active polyphenol extracted from green tea, has been shown to induce apoptosis and inhibit cell proliferation, cell invasion, angiogenesis and metastasis. Herein, we evaluated the in vivo ef…
View article: Immunomodulatory Effect of Green Tea Treatment in Combination with Low-dose Chemotherapy in Elderly Acute Myeloid Leukemia Patients with Myelodysplasia-related Changes
Immunomodulatory Effect of Green Tea Treatment in Combination with Low-dose Chemotherapy in Elderly Acute Myeloid Leukemia Patients with Myelodysplasia-related Changes Open
Green tea (GT) treatment was evaluated for its effect on the immune and antineoplastic response of elderly acute myeloid leukemia patients with myelodysplasia-related changes (AML-MRC) who are ineligible for aggressive chemotherapy and bon…
View article: Novel Non-Coding Transcript in NR4A3 Locus, LncNR4A3, Regulates RNA Processing Machinery Proteins and NR4A3 Expression
Novel Non-Coding Transcript in NR4A3 Locus, LncNR4A3, Regulates RNA Processing Machinery Proteins and NR4A3 Expression Open
NR4A3 is a key tumor suppressor in myeloid malignancy, mice lacking both NR4A1 and family member NR4A3 rapidly develop lethal acute myeloid leukemia (AML). We identified a long non-coding transcript in the NR4A3 locus and pursued the chara…
View article: A SUBFAMÍLIA RAC DE RHO GTPASES REPRESENTA UM POTENCIAL ALVO TERAPÊUTICO NA LEUCEMIA MIELOIDE AGUDA
A SUBFAMÍLIA RAC DE RHO GTPASES REPRESENTA UM POTENCIAL ALVO TERAPÊUTICO NA LEUCEMIA MIELOIDE AGUDA Open
View article: BRD4 Inhibition Enhances Azacitidine Efficacy in Acute Myeloid Leukemia and Myelodysplastic Syndromes
BRD4 Inhibition Enhances Azacitidine Efficacy in Acute Myeloid Leukemia and Myelodysplastic Syndromes Open
Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell-based disorders characterized by ineffective hematopoiesis, increased genomic instability and a tendency to progress toward acute myeloid leukemia (AML). MDS and AML cells …
View article: Up‐regulation of <scp>SPINT</scp>2/<scp>HAI</scp>‐2 by Azacytidine in bone marrow mesenchymal stromal cells affects leukemic stem cell survival and adhesion
Up‐regulation of <span>SPINT</span>2/<span>HAI</span>‐2 by Azacytidine in bone marrow mesenchymal stromal cells affects leukemic stem cell survival and adhesion Open
The role of tumour microenvironment in neoplasm initiation and malignant evolution has been increasingly recognized. However, the bone marrow mesenchymal stromal cell ( BMMSC ) contribution to disease progression remains poorly explored. W…
View article: Comparison of different methods to overexpress large genes
Comparison of different methods to overexpress large genes Open
Gain-of-function of very large transgene constructs can lead to genetic perturbations, providing researchers with the alternative of a powerful tool to identify pathway components which remain undetected when using traditional loss-of-func…
View article: SEMA3A partially reverses VEGF effects through binding to neuropilin-1
SEMA3A partially reverses VEGF effects through binding to neuropilin-1 Open
View article: Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplastic and leukemic cells due to integration of erythropoietin/PI3K pathway and regulation of erythropoiesis
Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplastic and leukemic cells due to integration of erythropoietin/PI3K pathway and regulation of erythropoiesis Open