Kenneth J. Vega
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View article: African and Hispanic Americans Have Higher Healthcare-Related Burden Without Higher Mortality When Admitted with Acute Diverticulitis
African and Hispanic Americans Have Higher Healthcare-Related Burden Without Higher Mortality When Admitted with Acute Diverticulitis Open
Background: Health disparities between racial groups continue to exist. There is a paucity of data regarding presentation severity for acute diverticulitis (AD) and surgery need by race. This study’s aim was to evaluate outcomes of AD in U…
View article: Formal Training in Bariatric Endoscopy: Assessing Interest and Need Among United States Gastroenterology Trainees
Formal Training in Bariatric Endoscopy: Assessing Interest and Need Among United States Gastroenterology Trainees Open
Background/aim: Obesity is a significant medical condition with substantial medical and financial burdens. Many patients eligible for metabolic and bariatric surgery (MBS) may never undergo weight loss surgery. Emerging techniques in the b…
View article: Age-related disparities in survival following colorectal cancer diagnosis in an underserved community in Georgia: A retrospective cohort analysis
Age-related disparities in survival following colorectal cancer diagnosis in an underserved community in Georgia: A retrospective cohort analysis Open
Advanced diagnoses were associated with a greater risk of mortality regardless of age group. Former smokers and those living in persistent poverty areas were also linked to increased mortality for 50-59 and 60-69 age groups, respectively. …
View article: Racial/Ethnic and Age-Related Disparities in Early-Onset Colorectal Cancer Diagnoses and Survival
Racial/Ethnic and Age-Related Disparities in Early-Onset Colorectal Cancer Diagnoses and Survival Open
Introduction Early-onset colorectal cancer (EOCRC) patients are more likely to have advanced diagnoses across different race/ethnicity or age at diagnosis groups. Thus, we examined the relationship of racial/ethnic disparities with cancer …
View article: <scp>HIV</scp> and Non‐<scp>HIV</scp> Patients Have Similar Rates of Neoplastic Findings on Screening Colonoscopy Within a Predominantly African American Cohort
<span>HIV</span> and Non‐<span>HIV</span> Patients Have Similar Rates of Neoplastic Findings on Screening Colonoscopy Within a Predominantly African American Cohort Open
Introduction With the reduction in human immunodeficiency virus (HIV)–related mortality secondary to antiretroviral therapy, chronic medical conditions and age‐related cancers account for a larger proportion of mortality among those with H…
View article: Single center assessment of the role of Oakland score among patients admitted for acute lower gastrointestinal bleeding
Single center assessment of the role of Oakland score among patients admitted for acute lower gastrointestinal bleeding Open
Background/Objectives The Oakland score was developed to predict safe discharge in patients who present to the emergency department with lower gastrointestinal bleeding (LGIB). In this study, we retrospectively evaluated if this score can …
View article: Thirty‑Day Readmission Rates and Outcomes after hospitalization for Ischemic Colitis. A National Analysis
Thirty‑Day Readmission Rates and Outcomes after hospitalization for Ischemic Colitis. A National Analysis Open
Background/Aim Limited data exists on 30-day readmission rates, readmission causes and predictors following Ischemic Colitis (IC). The aim is to identify etiologies for the above using a national database. Methods A retrospective cohort st…
View article: Disparities in esophageal cancer incidence and esophageal adenocarcinoma mortality in the United States over the last 25-40 years
Disparities in esophageal cancer incidence and esophageal adenocarcinoma mortality in the United States over the last 25-40 years Open
BACKGROUND Esophageal carcinoma presents as 2 types, esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC) with the frequency of both changing in the United States (US). AIM To investigate EAC/ESCC incidence time tr…
View article: Data from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase
Data from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase Open
Doublecortin-like kinase 1 (DCLK1) is a gastrointestinal (GI) tuft cell kinase that has been investigated as a biomarker of cancer stem–like cells in colon and pancreatic cancers. However, its utility as a biomarker may be limited in princ…
View article: Supplemental Figure Legends from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase
Supplemental Figure Legends from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase Open
A separate file containging supplemental figure legends as requested by the editorial office
View article: Supplemental Figures and Table from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase
Supplemental Figures and Table from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase Open
Supplemental material containing a flowchart for how the 15-miRNA signature was generated, a table of pertinent patient clinical data, and a forest plot of hazard ratios of high-risk colon, pancreatic, and stomach cancer patients with high…
View article: Supplemental Figure Legends from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase
Supplemental Figure Legends from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase Open
A separate file containging supplemental figure legends as requested by the editorial office
View article: Data from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase
Data from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase Open
Doublecortin-like kinase 1 (DCLK1) is a gastrointestinal (GI) tuft cell kinase that has been investigated as a biomarker of cancer stem–like cells in colon and pancreatic cancers. However, its utility as a biomarker may be limited in princ…
View article: Supplemental Figures and Table from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase
Supplemental Figures and Table from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase Open
Supplemental material containing a flowchart for how the 15-miRNA signature was generated, a table of pertinent patient clinical data, and a forest plot of hazard ratios of high-risk colon, pancreatic, and stomach cancer patients with high…
View article: Expanding beyond endoscopy: A review of non-invasive modalities in Barrett’s esophagus screening and surveillance
Expanding beyond endoscopy: A review of non-invasive modalities in Barrett’s esophagus screening and surveillance Open
Barrett's esophagus (BE) is a condition that results from replacement of the damaged normal squamous esophageal mucosa to intestinal columnar mucosa and is the most significant predisposing factor for development of esophageal adenocarcino…
View article: Tokyo Guidelines (TG18) for Acute Cholangitis Provide Improved Specificity and Accuracy Compared to Fellow Assessment
Tokyo Guidelines (TG18) for Acute Cholangitis Provide Improved Specificity and Accuracy Compared to Fellow Assessment Open
Background Acute cholangitis results in significant mortality unless treated promptly. The diagnostic grading criteria of the 2018 Tokyo Guidelines (TG18) are used worldwide as the standard for acute cholangitis (AC) management but validat…
View article: Consensus Molecular Subtypes Efficiently Classify Gastric Adenocarcinomas and Predict the Response to Anti-PD-1 Immunotherapy
Consensus Molecular Subtypes Efficiently Classify Gastric Adenocarcinomas and Predict the Response to Anti-PD-1 Immunotherapy Open
Background: Gastric adenocarcinoma (GAC) is highly heterogeneous and closely related to colorectal cancer (CRC) both molecularly and functionally. GAC is currently subtyped using a system developed by TCGA. However, with the emergence of i…
View article: An Unusual Long-Term Complication of Bariatric Surgery
An Unusual Long-Term Complication of Bariatric Surgery Open
Roux-en-Y gastric bypass (RNYGB) has become the standard of care in treating obesity, a global health concern with associated comorbidities contributing to rising health care costs [1]. The positive outcomes of RNYGB have been well documen…
View article: Type-2 cGMP-dependent protein kinase suppresses proliferation and carcinogenesis in the colon epithelium
Type-2 cGMP-dependent protein kinase suppresses proliferation and carcinogenesis in the colon epithelium Open
A large body of evidence has demonstrated that cyclic-guanosine monophosphate (cGMP), signaling has anti-tumor effects that might be used for colon cancer prevention. The tumor-suppressive mechanism and the signaling components downstream …
View article: Spontaneous duodenal fistulisation from walled-off pancreatic necrosis
Spontaneous duodenal fistulisation from walled-off pancreatic necrosis Open
Walled-off pancreatic necrosis (WOPN) is a known complication of pancreatitis. It can be complicated by infection, haemorrhage and, rarely, fistulisation. Here we present a rare case of WOPN with duodenal fistulisation. A woman with medica…
View article: Artificial intelligence as a means to improve recognition of gastrointestinal angiodysplasia in video capsule endoscopy
Artificial intelligence as a means to improve recognition of gastrointestinal angiodysplasia in video capsule endoscopy Open
Artificial intelligence as a means to improve recognition of gastrointestinal angiodysplasia in video capsule endoscopy
View article: Sex-Associated Gene Expression Alterations Correlate With Esophageal Cancer Survival
Sex-Associated Gene Expression Alterations Correlate With Esophageal Cancer Survival Open
OBJECTIVES: Esophageal cancer (EC) is a significant cause of cancer death with 5-year survival of 10%–15% and males more frequently affected. Genetic evaluation for loci highlighting risk has been performed, but survival data are limited. …
View article: Reverse engineering a predictive signature characterized by proliferation, DNA damage, and immune escape from stage I lung adenocarcinoma recurrence
Reverse engineering a predictive signature characterized by proliferation, DNA damage, and immune escape from stage I lung adenocarcinoma recurrence Open
Identifying early-stage cancer patients at risk for progression is a major goal of biomarker research. This report describes a novel 19-gene signature (19-GCS) that predicts stage I lung adenocarcinoma (LAC) recurrence and response to ther…