Karol E. Watson
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View article: Cardiovascular Risk Associated with Menopause and Menopause Hormone Therapy: A Review and Contemporary Approach to Risk Assessment
Cardiovascular Risk Associated with Menopause and Menopause Hormone Therapy: A Review and Contemporary Approach to Risk Assessment Open
View article: Association of BMI and Cognitive Performance in the Diabetes Prevention Program Outcomes Study
Association of BMI and Cognitive Performance in the Diabetes Prevention Program Outcomes Study Open
Objective This study aimed to examine the association of BMI with cognitive performance in individuals with diabetes or prediabetes. Methods Among Diabetes Prevention Program Outcomes Study (DPPOS) participants, BMI was categorized as norm…
View article: 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines Open
AIM: The “2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults” retires and replaces the “2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/A…
View article: Sex-Difference of Associations between Cigarette Smoking and Myocardial Fibrosis: The Multi-Ethnic Study of Atherosclerosis
Sex-Difference of Associations between Cigarette Smoking and Myocardial Fibrosis: The Multi-Ethnic Study of Atherosclerosis Open
Background: Extracellular volume (ECV) and native T1 time (nT1) are markers of interstitial-myocardial-fibrosis (IMF) by cardiac MRI (CMR) and are associated with CV events, heart failure and death. However, the association between smoking…
View article: Proteomic discovery analysis of quantitatively assessed emphysema in the general population. The MESA Lung Study
Proteomic discovery analysis of quantitatively assessed emphysema in the general population. The MESA Lung Study Open
Background Pulmonary emphysema occurs frequently in older adults, often without airflow limitation. Its presence predicts symptoms, respiratory hospitalizations and deaths, and all-cause mortality. Proteomics may provide further insights i…
View article: Quantifying the impact of early-life growth adversity on later-life health
Quantifying the impact of early-life growth adversity on later-life health Open
Background Early-life growth adversity is important to later-life health, but precision assessment in adulthood is challenging. We evaluated whether the difference between attained and genotype-predicted adult height (“height-GaP”) would a…
View article: Baseline Cardiac Biomarker Levels as Predictors of Cancer Risk in the MESA Cohort
Baseline Cardiac Biomarker Levels as Predictors of Cancer Risk in the MESA Cohort Open
In the MESA cohort, higher baseline levels of hs-cTnT and NT-proBNP predicted an increased risk of incident cancer, with no significant differences by race/ethnicity or sex.
View article: Building an Ethical and Trustworthy Biomedical AI Ecosystem Centered on Foundational Models and Multimodal Biomedical Data
Building an Ethical and Trustworthy Biomedical AI Ecosystem Centered on Foundational Models and Multimodal Biomedical Data Open
View article: Metadata Supported in context learning with GPT improves Cardiovascular Patient Diagnostic Outcomes Using Cardiovascular Clinical Case Reports
Metadata Supported in context learning with GPT improves Cardiovascular Patient Diagnostic Outcomes Using Cardiovascular Clinical Case Reports Open
View article: Missing Values in Longitudinal Proteomics Studies: Making a Case for Data Multiple Imputation
Missing Values in Longitudinal Proteomics Studies: Making a Case for Data Multiple Imputation Open
View article: Bridge2AI: Building A Cross-disciplinary Curriculum Towards AI-Enhanced Biomedical and Clinical Care
Bridge2AI: Building A Cross-disciplinary Curriculum Towards AI-Enhanced Biomedical and Clinical Care Open
Objective: As AI becomes increasingly central to healthcare, there is a pressing need for bioinformatics and biomedical training systems that are personalized and adaptable. Materials and Methods: The NIH Bridge2AI Training, Recruitment, a…
View article: Examining the relationship between anthropometric and body composition measures with coronary heart disease events: the multi-ethnic study of atherosclerosis
Examining the relationship between anthropometric and body composition measures with coronary heart disease events: the multi-ethnic study of atherosclerosis Open
Aims Obesity, traditionally measured using body mass index (BMI), is considered a significant risk factor for the development of cardiovascular disease (CVD). However, there have been mixed findings regarding the association between obesit…
View article: Novel Virtual Reality Intervention for Stress Reduction Among Patients With or at Risk for Cardiovascular Disease: Mixed Methods Pilot Study
Novel Virtual Reality Intervention for Stress Reduction Among Patients With or at Risk for Cardiovascular Disease: Mixed Methods Pilot Study Open
Background Virtual reality (VR) has emerged as a promising, low-risk strategy to manage many forms of psychological stress and may be a modality to improve cardiovascular health. Recent scientific statements on the mind-heart-body connecti…
View article: Body Composition and Mortality Throughout the Reproductive Cycle: Findings from The Multi-Ethnic Study of Atherosclerosis (MESA)
Body Composition and Mortality Throughout the Reproductive Cycle: Findings from The Multi-Ethnic Study of Atherosclerosis (MESA) Open
View article: United States Pooled Cohort Cardiovascular Disease Risk Scores in Adults With Diabetes Mellitus
United States Pooled Cohort Cardiovascular Disease Risk Scores in Adults With Diabetes Mellitus Open
Our U.S. pooled cohort DMRS for predicting CVD events demonstrated good predictive performance for assessing CVD risk in adults with DM.
View article: Perspective: Current Scientific Evidence and Research Strategies in the Role of Almonds in Cardiometabolic Health
Perspective: Current Scientific Evidence and Research Strategies in the Role of Almonds in Cardiometabolic Health Open
View article: Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic
Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic Open
Importance The end of the COVID-19 public health emergency (PHE) provides an opportunity to fully describe pandemic-associated racial and ethnic mortality disparities. Age-specific excess mortality differences have important downstream imp…
View article: Building an Ethical and Trustworthy Biomedical AI Ecosystem for the Translational and Clinical Integration of Foundation Models
Building an Ethical and Trustworthy Biomedical AI Ecosystem for the Translational and Clinical Integration of Foundation Models Open
Foundation Models (FMs) are gaining increasing attention in the biomedical artificial intelligence (AI) ecosystem due to their ability to represent and contextualize multimodal biomedical data. These capabilities make FMs a valuable tool f…
View article: Cardiovascular Risks and Outcomes Among Chinese American Immigrants: Insights From the Multi‐Ethnic Study of Atherosclerosis
Cardiovascular Risks and Outcomes Among Chinese American Immigrants: Insights From the Multi‐Ethnic Study of Atherosclerosis Open
Background Immigrants experience changes in cardiovascular risk factors and racial disparities in both cardiovascular health prevention and outcomes upon immigration. We aimed to examine cardiovascular risk factors and outcomes among Chine…
View article: Missing Values in Longitudinal Proteome Dynamics Studies: Making a Case for Data Multiple Imputation
Missing Values in Longitudinal Proteome Dynamics Studies: Making a Case for Data Multiple Imputation Open
Temporal proteomics data sets are often confounded by the challenges of missing values. These missing data points, in a time-series context, can lead to fluctuations in measurements or the omission of critical events, thus hindering the ab…
View article: Building an Ethical and Trustworthy Biomedical AI Ecosystem for the Translational and Clinical Integration of Foundational Models
Building an Ethical and Trustworthy Biomedical AI Ecosystem for the Translational and Clinical Integration of Foundational Models Open
Foundational Models (FMs) are gaining increasing attention in the biomedical AI ecosystem due to their ability to represent and contextualize multimodal biomedical data. These capabilities make FMs a valuable tool for a variety of tasks, i…
View article: A Technology-Assisted Web Application for Consumer Access to a Nonprescription Statin Medication
A Technology-Assisted Web Application for Consumer Access to a Nonprescription Statin Medication Open
In this actual use study, a technology-assisted Web App allowed >90% of consumers to correctly self-select for statin use and achieve clinically important LDL-C reductions. (Technology-Assisted Cholesterol Trial in Consumers [TACTiC]; NCT0…
View article: Impact of COVID-19 Pandemic on Sex and Racial Disparities in Chest Pain Presentation and Management Through the Emergency Department
Impact of COVID-19 Pandemic on Sex and Racial Disparities in Chest Pain Presentation and Management Through the Emergency Department Open
During COVID-19, females, especially Asian females, were less likely to present to the ED for chest pain. Non-White patients were less likely to present to the ED compared to White patients prior to and during the pandemic. Disparities in …
View article: Age-Specific All-Cause Mortality Disparities by Race and Ethnicity During the COVID-19 Pandemic
Age-Specific All-Cause Mortality Disparities by Race and Ethnicity During the COVID-19 Pandemic Open
BACKGROUND The end of the public health emergency provides an opportunity to fully describe disparities during the Covid-19 pandemic. METHODS In this retrospective cohort analysis of US deaths during the Covid-19 public health emergency (M…
View article: Associations Between Visceral Fat, Abdominal Muscle, and Coronary Artery Calcification: A Cross-Sectional Analysis of the Multi-Ethnic Study of Atherosclerosis
Associations Between Visceral Fat, Abdominal Muscle, and Coronary Artery Calcification: A Cross-Sectional Analysis of the Multi-Ethnic Study of Atherosclerosis Open
The associations of body composition components, including muscle and adipose tissue, and markers of subclinical coronary artery disease are unclear. We examined the relation between abdominal computed tomography (CT)-derived measures of t…
View article: Robust deep labeling of radiological emphysema subtypes using squeeze and excitation convolutional neural networks: The MESA Lung and SPIROMICS Studies
Robust deep labeling of radiological emphysema subtypes using squeeze and excitation convolutional neural networks: The MESA Lung and SPIROMICS Studies Open
Pulmonary emphysema, the progressive, irreversible loss of lung tissue, is conventionally categorized into three subtypes identifiable on pathology and on lung computed tomography (CT) images. Recent work has led to the unsupervised learni…
View article: Airway tree caliber heterogeneity and airflow obstruction among older adults
Airway tree caliber heterogeneity and airflow obstruction among older adults Open
In this study, by leveraging two community-based samples and a case-control study of heavy smokers, we show that among older adults, airway tree caliber heterogeneity quantified by CT is associated with airflow obstruction and COPD indepen…
View article: Robust Quantification of Percent Emphysema on CT via Domain Attention: the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study
Robust Quantification of Percent Emphysema on CT via Domain Attention: the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study Open
Robust quantification of pulmonary emphysema on computed tomography (CT) remains challenging for large-scale research studies that involve scans from different scanner types and for translation to clinical scans. Existing studies have expl…
View article: Peripheral Blood Mononuclear Cell Gene Expression Associated with Pulmonary Microvascular Perfusion: The Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease
Peripheral Blood Mononuclear Cell Gene Expression Associated with Pulmonary Microvascular Perfusion: The Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease Open
Rationale: Chronic obstructive pulmonary disease (COPD) and emphysema are associated with endothelial damage and altered pulmonary microvascular perfusion. The molecular mechanisms underlying these changes are poorly understood in p…
View article: Adipokines and adiposity among postmenopausal women of the Multi-Ethnic Study of Atherosclerosis
Adipokines and adiposity among postmenopausal women of the Multi-Ethnic Study of Atherosclerosis Open
Objective We investigated whether the associations of serum adiponectin, leptin, and resistin with adiposity differ with menopausal age. Methods In this cross-sectional study, we included 751 postmenopausal women from the Multi-Ethnic Stud…