Karolina A. Åberg
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View article: Cell type-specific methylome-wide association studies of childhood ADHD symptoms
Cell type-specific methylome-wide association studies of childhood ADHD symptoms Open
Studying DNA methylation (DNAm) can provide insights into gene-regulatory mechanisms underlying attention-deficit/hyperactivity disorder (ADHD). While most DNAm studies were performed in bulk tissue, this study used statistical deconvoluti…
View article: DNA Methylation Signatures of Alcohol Use Disorder – A large-scale Meta-Analysis in the Psychiatric Genomics Consortium
DNA Methylation Signatures of Alcohol Use Disorder – A large-scale Meta-Analysis in the Psychiatric Genomics Consortium Open
Despite extensive research on DNA methylation (DNAm) signatures associated with alcohol use disorder (AUD), findings are often inconsistent and not replicated. We conducted a large-scale meta-analysis of epigenome-wide association studies …
View article: Sex-stratified analysis of the potential association between PGLYRP2 rs892145 variant and Parkinson’s disease across diverse ancestral populations
Sex-stratified analysis of the potential association between PGLYRP2 rs892145 variant and Parkinson’s disease across diverse ancestral populations Open
Variants in PGLYRP2 , particularly rs892145-T, have been suggested as Parkinson’s disease (PD) risk factors. We analyzed data from 31,334 PD patients and 17,772 controls across diverse ancestries. A significant sex-dependent effect of rs89…
View article: Cell type-specific methylome-wide association studies of childhood ADHD symptoms
Cell type-specific methylome-wide association studies of childhood ADHD symptoms Open
Objective Studying DNA methylation (DNAm) can provide insights into gene-regulatory mechanisms underlying attention-deficit/hyperactivity disorder (ADHD). While most DNAm studies were performed in bulk tissue, this study used statistical d…
View article: Insights from a methylome-wide association study of antidepressant exposure
Insights from a methylome-wide association study of antidepressant exposure Open
This study tests the association of whole-blood DNA methylation and antidepressant exposure in 16,531 individuals from Generation Scotland (GS), using self-report and prescription-derived measures. We identify 8 associations and a high con…
View article: Intensive Short-Term Dynamic Psychotherapy for depression: Treatment effectiveness and effects of unlocking the unconscious
Intensive Short-Term Dynamic Psychotherapy for depression: Treatment effectiveness and effects of unlocking the unconscious Open
Intensive Short-Term Dynamic Psychotherapy (ISTDP) has an increasing amount of evidence regarding its efficacy across various psychiatric conditions and specifically with depression. The aim of this study is to replicate the findings of co…
View article: Intensive Short-Term Dynamic Psychotherapy for depression: Treatment effectiveness and effects of unlocking the unconscious
Intensive Short-Term Dynamic Psychotherapy for depression: Treatment effectiveness and effects of unlocking the unconscious Open
Intensive Short-Term Dynamic Psychotherapy (ISTDP) has an increasing amount of evidence regarding its efficacy across various psychiatric conditions and specifically with depression. The aim of this study is to replicate the findings of co…
View article: Cell-type specific methylation changes in the newborn child associated to obstetric pain relief
Cell-type specific methylation changes in the newborn child associated to obstetric pain relief Open
Although it is widely known that various pharmaceuticals affect the methylome, the knowledge of the effects from anesthesia is limited, and nearly nonexistent regarding the effects of obstetric anesthesia on the newborn child. Using sequen…
View article: Lagged effects of childhood depressive symptoms on adult epigenetic aging
Lagged effects of childhood depressive symptoms on adult epigenetic aging Open
Background Cross-sectional studies have identified health risks associated with epigenetic aging. However, it is unclear whether these risks make epigenetic clocks ‘tick faster’ (i.e. accelerate biological aging). The current study examine…
View article: PRC2-AgeIndex as a universal biomarker of aging and rejuvenation
PRC2-AgeIndex as a universal biomarker of aging and rejuvenation Open
DNA methylation (DNAm) is one of the most reliable biomarkers of aging across mammalian tissues. While the age-dependent global loss of DNAm has been well characterized, DNAm gain is less characterized. Studies have demonstrated that CpGs …
View article: Investigating neonatal health risk variables through cell-type specific methylome-wide association studies
Investigating neonatal health risk variables through cell-type specific methylome-wide association studies Open
Adverse neonatal outcomes are a prevailing risk factor for both short- and long-term mortality and morbidity in infants. Given the importance of these outcomes, refining their assessment is paramount for improving prevention and care. Here…
View article: Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression
Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression Open
While more samples are needed to reach genome-wide levels of significance, the results presented confirm PPD as a polygenic and heritable phenotype. There is also evidence that despite a high correlation with MDD, PPD may have unique genet…
View article: Fine-grained cell-type specific association studies with human bulk brain data using a large single-nucleus RNA sequencing based reference panel
Fine-grained cell-type specific association studies with human bulk brain data using a large single-nucleus RNA sequencing based reference panel Open
Brain disorders are leading causes of disability worldwide. Gene expression studies provide promising opportunities to better understand their etiology but it is critical that expression is studied on a cell-type level. Cell-type specific …
View article: A method to improve the reproducibility of findings from epigenome- and transcriptome-wide association studies
A method to improve the reproducibility of findings from epigenome- and transcriptome-wide association studies Open
Reproducibility is a cornerstone of scientific progress. In epigenome- and transcriptome-wide association studies (E/TWAS) failure to reproduce may be the result of false discoveries. Whereas multiple methods exist to control false discove…
View article: Fine-grained deconvolution of cell-type effects from human bulk brain data using a large single-nucleus RNA sequencing based reference panel
Fine-grained deconvolution of cell-type effects from human bulk brain data using a large single-nucleus RNA sequencing based reference panel Open
Brain disorders are leading causes of disability worldwide. Gene expression studies provide promising opportunities to better understand their etiology. When studying bulk tissue, cellular diversity may cause many genes that are differenti…
View article: A single-nucleus transcriptomics study of alcohol use disorder in the nucleus accumbens
A single-nucleus transcriptomics study of alcohol use disorder in the nucleus accumbens Open
Alcohol use disorder (AUD) is a significant public health problem. Gene expression studies offer promising opportunities to better understand the underlying pathogenic processes. As cell-types differ in their function, gene expression prof…
View article: PRC2 clock: a universal epigenetic biomarker of aging and rejuvenation
PRC2 clock: a universal epigenetic biomarker of aging and rejuvenation Open
DNA methylation (DNAm) is one of the most reliable biomarkers for aging across many mammalian tissues. While the age-dependent global loss of DNAm has been well characterized, age-dependent DNAm gain is less specified. Multiple studies hav…
View article: Early adversities accelerate epigenetic aging into adulthood: a 10‐year, within‐subject analysis
Early adversities accelerate epigenetic aging into adulthood: a 10‐year, within‐subject analysis Open
Background Longitudinal studies are needed to clarify whether early adversities are associated with advanced methylation age or if they actually accelerate methylation aging. This study test whether different dimensions of childhood advers…
View article: Dual methylation and hydroxymethylation study of alcohol use disorder
Dual methylation and hydroxymethylation study of alcohol use disorder Open
Using an integrative, multi‐tissue design, we sought to characterize methylation and hydroxymethylation changes in blood and brain associated with alcohol use disorder (AUD). First, we used epigenomic deconvolution to perform cell‐type‐spe…
View article: A methylation study implicates the rewiring of brain neural circuits during puberty in the emergence of sex differences in depression symptoms
A methylation study implicates the rewiring of brain neural circuits during puberty in the emergence of sex differences in depression symptoms Open
Background Women are 1.5–3 times more likely to suffer from depression than men. This sex bias first emerges during puberty and then persists across the reproductive years. As the cause remains largely elusive, we performed a methylation‐w…
View article: Refinement of schizophrenia GWAS loci using methylome-wide association data
Refinement of schizophrenia GWAS loci using methylome-wide association data Open
Recent genome-wide association studies (GWAS) have made substantial progress in identifying disease loci. The next logical step is to design functional experiments to identify disease mechanisms. This step, however, is often hampered by th…
View article: An integrative study of five biological clocks in somatic and mental health
An integrative study of five biological clocks in somatic and mental health Open
Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders. However, it is unclear whether different biological clocks reflect similar agin…
View article: Post-Mortem Brain Nuclei Isolation for Single Nucleus RNA Sequencing
Post-Mortem Brain Nuclei Isolation for Single Nucleus RNA Sequencing Open
\nPost-Mortem Brain Nuclei Isolation for Single Nucleus RNA Sequencing\nCharles Tran, Dept. of Biology, with Dr. Karolina Aberg, VCU School of Pharmacy\nWhen tissue samples are studied in bulk without consideration for different cell propo…
View article: Additional file 2 of A targeted solution for estimating the cell-type composition of bulk samples
Additional file 2 of A targeted solution for estimating the cell-type composition of bulk samples Open
Additional file 2. Supplementary Tables.