Karoline Strobl
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View article: JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia
JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia Open
The hair follicle stem cell niche is an immune-privileged microenvironment, characterized by reduced antigen presentation, thus shielding against permanent immune-mediated tissue damage. In this study, we demonstrated the protective role o…
View article: Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege
Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege Open
The hair follicle stem cell niche is an immune-privileged microenvironment, characterised by suppressed antigen presentation, thus shielding against permanent immune-mediated tissue damage. In this study, we demonstrate the protective role…
View article: IL-2 availability regulates the tissue specific phenotype of murine intra-hepatic Tregs
IL-2 availability regulates the tissue specific phenotype of murine intra-hepatic Tregs Open
CD4+CD25+Foxp3+ Tregs are known to acquire tissue-specific features and exert cytoprotective and regenerative functions. The extent to which this applies to liver-resident Tregs is unknown. In this study, we aimed to explore the phenotypic…