Karsten Hiller
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View article: MacroD1 sustains mitochondrial integrity and oxidative metabolism
MacroD1 sustains mitochondrial integrity and oxidative metabolism Open
View article: Postprandial Metabolism, Inflammation, and Plasma Bile Acid Kinetics in a Rat Model: Implications for Translational Research
Postprandial Metabolism, Inflammation, and Plasma Bile Acid Kinetics in a Rat Model: Implications for Translational Research Open
The postprandial period is an opportunity window to assess metabolic phenotype, and its study is gaining popularity due to the wealth of information that can be uncovered when a dietary challenge is associated with the application of metab…
View article: Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism
Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism Open
View article: Trained Immunity Induced by Oxidized Low‐Density Lipoprotein Is Dependent on Glutaminolysis
Trained Immunity Induced by Oxidized Low‐Density Lipoprotein Is Dependent on Glutaminolysis Open
Atherosclerosis is a chronic inflammatory disease of the arterial wall that causes cardiovascular disease. Monocyte‐derived macrophages are an important contributor to atherogenesis. Monocytes can become primed for higher responsiveness to…
View article: Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions
Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions Open
View article: Oxidative phosphorylation is a key feature of neonatal monocyte immunometabolism promoting myeloid differentiation after birth
Oxidative phosphorylation is a key feature of neonatal monocyte immunometabolism promoting myeloid differentiation after birth Open
Neonates primarily rely on innate immune defense, yet their inflammatory responses are usually restricted compared to adults. This is controversially interpreted as a sign of immaturity or essential programming, increasing or decreasing th…
View article: Kupffer cells control neonatal hepatic metabolism via Igf1 signaling
Kupffer cells control neonatal hepatic metabolism via Igf1 signaling Open
During perinatal development, liver metabolism is tightly regulated to ensure energy supply for the newborn. Before birth, glycogen is stored in hepatocytes and later metabolized to glucose, meeting the energy demands of the neonate. Short…
View article: ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance
ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance Open
We identified ACC1 as a metabolic checkpoint in Treg biology. Our data demonstrate that ACC1 inhibition promotes Treg differentiation and long-term stability in vitro and in vivo. Thus, ACC1 serves as a dual metabolic and epigenetic hub, r…
View article: NLRP3 regulates immunometabolism, impacting microglial function in Alzheimer’s disease
NLRP3 regulates immunometabolism, impacting microglial function in Alzheimer’s disease Open
Background Our laboratory has demonstrated that the NLRP3 inflammasome has a critical role in the microglial innate immune response to Alzheimer’s disease (AD)‐related peptides, triggering the release of cleaved‐caspase‐1 and IL‐1β. NLRP3 …
View article: Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity
Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity Open
Type 2 diabetes (T2D) and obesity are strongly associated with low natriuretic peptide (NP) plasma levels and a down-regulation of NP guanylyl cyclase receptor-A (GCA) in skeletal muscle and adipose tissue. However, no study has so far pro…
View article: Author Correction: Oligodendroglial fatty acid metabolism as a central nervous system energy reserve
Author Correction: Oligodendroglial fatty acid metabolism as a central nervous system energy reserve Open
View article: Oligodendroglial fatty acid metabolism as a central nervous system energy reserve
Oligodendroglial fatty acid metabolism as a central nervous system energy reserve Open
Brain function requires a constant supply of glucose. However, the brain has no known energy stores, except for glycogen granules in astrocytes. In the present study, we report that continuous oligodendroglial lipid metabolism provides an …
View article: Dry blood spots as a sampling strategy to identify insulin resistance markers during a dietary challenge
Dry blood spots as a sampling strategy to identify insulin resistance markers during a dietary challenge Open
This study aimed to identify markers of postprandial dysglycemia in the blood of self-described healthy individuals using dry blood spots (DBS) as a sampling strategy. A total of 54 volunteers, including 31 women, participated in a dietary…
View article: Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity
Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity Open
The efficacy of antitumor immunity is associated with the metabolic state of cytotoxic T cells, which is sensitive to the tumor microenvironment. Whether ionic signals affect adaptive antitumor immune responses is unclear. In the present s…
View article: The potential therapeutic role of itaconate and mesaconate on the detrimental effects of LPS-induced neuroinflammation in the brain
The potential therapeutic role of itaconate and mesaconate on the detrimental effects of LPS-induced neuroinflammation in the brain Open
View article: Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells
Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells Open
The microbiome is a complex host factor and key determinant of the outcome of antibody-based and cellular immunotherapy. Its postbiotics are a blend of soluble commensal byproducts that are released into the host environment and have been …
View article: Phosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation
Phosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation Open
View article: D-limonene supplementation does not alter postprandial metabolism of postmenopausal women challenged with a mixed macronutrient tolerance test: a pilot study
D-limonene supplementation does not alter postprandial metabolism of postmenopausal women challenged with a mixed macronutrient tolerance test: a pilot study Open
The hormonal decline during menopause increases women's risk of chronic diseases. D-limonene, a monoterpene found in the human diet, possesses biological properties related to hypolipemic, antioxidant, anti-inflammatory, and gut microbiota…
View article: The potential therapeutic role of itaconate and mesaconate on the detrimental effects of LPS-induced neuroinflammation in the brain
The potential therapeutic role of itaconate and mesaconate on the detrimental effects of LPS-induced neuroinflammation in the brain Open
Despite advances in antimicrobial and anti-inflammatory treatment, inflammation and its consequences remain a major challenge in the field of medicine. Inflammatory reactions can lead to life-threatening conditions such as septic shock, wh…
View article: Metabolic adaptation in epithelial ovarian cancer metastasis
Metabolic adaptation in epithelial ovarian cancer metastasis Open
Epithelial ovarian cancer (EOC) is highly lethal due to its unique metastatic characteristics. EOC spheroids enter a non-proliferative state, with hypoxic cores and reduced oncogenic signaling, all of which contribute to tumour dormancy du…
View article: Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis
Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis Open
View article: From Planning Stage Towards FAIR Data: A Practical Metadatasheet For Biomedical Scientists
From Planning Stage Towards FAIR Data: A Practical Metadatasheet For Biomedical Scientists Open
View article: Targeting glutaminolysis pathway in trained immunity induced by oxidized low-density lipoprotein
Targeting glutaminolysis pathway in trained immunity induced by oxidized low-density lipoprotein Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Deutsche Forschungsgemeinschaft DFG Atherosclerosis is a chronic inflammatory disease of the arterial wall that causes cardio…
View article: Anabolic lipid metabolism regulates adipose type 2 innate lymphoid cell differentiation to maintain metabolic health
Anabolic lipid metabolism regulates adipose type 2 innate lymphoid cell differentiation to maintain metabolic health Open
Summary Group 2 innate lymphoid cells (ILC2) residing in the adipose tissue play an important role in maintaining the metabolic health and energy balance of the organisms. In obesity ILC2 numbers are reduced and their function is impaired,…
View article: Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis
Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis Open
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor regulating xenobiotic responses as well as physiological metabolism. Dietary AhR ligands activate the AhR signaling axis in the intestine and throughout the org…
View article: Metabolomics analysis reveals novel serum metabolite alterations in cancer cachexia
Metabolomics analysis reveals novel serum metabolite alterations in cancer cachexia Open
Background Cachexia is a body wasting syndrome that significantly affects well-being and prognosis of cancer patients, without effective treatment. Serum metabolites take part in pathophysiological processes of cancer cachexia, but apart f…
View article: Markers of Dysmetabolism Revealed Using a Dietary Challenge and Dry Blood Spots in a Remotely Executed Clinical Trial
Markers of Dysmetabolism Revealed Using a Dietary Challenge and Dry Blood Spots in a Remotely Executed Clinical Trial Open
Background and Objectives: The physiological changes that take place after the ingestion of a meal are largely controlled by insulin and can reflect changes in the response to this hormone. Different studies have reported metabolic differe…
View article: An Animal Model to Investigate Postprandial Metabolism
An Animal Model to Investigate Postprandial Metabolism Open
Background and Objectives: Bile acids (BA) are recognized as metabolic integrators that participate in the regulation of energy metabolism and inflammation. Their concentration in the plasma increases several-fold after a meal. The postpra…
View article: From Planning Stage To FAIR Data: A Practical Metadatasheet For Biomedical Scientists
From Planning Stage To FAIR Data: A Practical Metadatasheet For Biomedical Scientists Open
Datasets consist of measurement data and metadata. Metadata provides context, essential for understanding and (re-)using data. Various metadata standards exist for different methods, systems and contexts. However, relevant information resi…
View article: MeTEor: an R Shiny app for exploring longitudinal metabolomics data
MeTEor: an R Shiny app for exploring longitudinal metabolomics data Open
Motivation The availability of longitudinal omics data is increasing in metabolomics research. Viewing metabolomics data over time provides detailed insight into biological processes and fosters understanding of how systems react over time…