Karthickeyan Chella Krishnan

Functional compartmentalization of hepatic mitochondrial subpopulations during MASH progression Open

Noble Kumar Talari, Ushodaya Mattam, Afra Rahman, Brook K. Hemmelgarn, Michael A. Wyder , et al. · 2025

Current Advances and Future Directions of Pluripotent Stem Cells-Derived Engineered Heart Tissue for Treatment of Cardiovascular Diseases Open

Xingyu He, Augusta Good, Wael Kalou, Waqas Ahmad, Suchandrima Dutta , et al. · 2024

Cardiovascular diseases resulting from myocardial infarction (MI) remain a leading cause of death worldwide, imposing a substantial burden on global health systems. Current MI treatments, primarily pharmacological and surgical, do not rege…

Isolated Mouse Adult Cardiomyocytes Display Minimal Mitochondrial ATP Demand and Maximal Reliance on Glycolysis Open

Ushodaya Mattam, Noble Kumar Talari, Ashish Rao Sathyanarayana, Sobuj Mia, James Frazier , et al. · 2024

Mitochondrial maladaptation is a hallmark of heart failure, contributing to impaired energy production and contractile dysfunction. Understanding the bioenergetics of cardiomyocytes under healthy and pathological conditions is critical for…

Hepatokine ITIH3 protects against hepatic steatosis by downregulating mitochondrial bioenergetics and de novo lipogenesis Open

Noble Kumar Talari, Ushodaya Mattam, Dorota Kamińska, Irene Sotomayor-Rodriguez, Afra Rahman , et al. · 2024

When diet meets genetics Open

Karthickeyan Chella Krishnan · 2023

Gene expression profiling of a diverse mouse population helps to decipher how a fat-rich diet contributes to inflammatory bowel disease.

Mammary duct luminal epithelium controls adipocyte thermogenic programme Open

Sanil Patel, Njeri Sparman, Douglas Arneson, Alexandra Alvarsson, LETÍCIA VITÓRIA DA SILVA SANTOS , et al. · 2023

Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy Open

Karthickeyan Chella Krishnan, Elie-Julien El Hachem, Mark P. Keller, Sanjeet Patel, Luke Carroll , et al. · 2023

Mitochondria play an important role in both normal heart function and disease etiology. We report analysis of common genetic variations contributing to mitochondrial and heart functions using an integrative proteomics approach in a panel o…

Author response: Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy Open

Karthickeyan Chella Krishnan, Elie-Julien El Hachem, Mark P. Keller, Sanjeet Patel, Luke Carroll , et al. · 2023

Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract Mitochondria play an …

Genetic Architecture of Heart Mitochondrial Proteome influencing Cardiac Hypertrophy Open

Karthickeyan Chella Krishnan, Elie-Julien El Hachem, Luke Carroll, Alexis Díaz‐Vegas, Christine Light , et al. · 2022

Mitochondria play a key role in the normal function of the heart as well as in the pathogenesis of diseases. We report analysis of common genetic variations contributing to mitochondrial and heart functions using an integrative proteomics …

Sex differences in heart mitochondria regulate diastolic dysfunction Open

Yang Cao, Laurent Vergnes, Yu-Chen Wang, Calvin Pan, Karthickeyan Chella Krishnan , et al. · 2022

Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2 Open

Karthickeyan Chella Krishnan, Laurent Vergnes, Rebeca Acı́n-Pérez, Linsey Stiles, Michaël Shum , et al. · 2021

We have previously suggested a central role for mitochondria in the observed sex differences in metabolic traits. However, the mechanisms by which sex differences affect adipose mitochondrial function and metabolic syndrome are unclear. He…

Recruitment and remodeling of peridroplet mitochondria in human adipose tissue Open

Rebeca Acı́n-Pérez, Anton Petcherski, Michaela Veliova, Ilan Y. Benador, Essam A. Assali , et al. · 2021

Beige adipocyte mitochondria contribute to thermogenesis by uncoupling and by ATP-consuming futile cycles. Since uncoupling may inhibit ATP synthesis, it is expected that expenditure through ATP synthesis is segregated to a disparate popul…

ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity Open

Michaël Shum, C.A. Shintre, Thorsten Althoff, Vincent Gutierrez, Mayuko Segawa , et al. · 2021

ABCB10 in the liver impairs insulin signaling and promotes hyperglycemia and steatosis.

ScRNA-seq Reveals a Role of Mammary Luminal Epithelium in Adipocyte Adaptations Open

LETÍCIA VITÓRIA DA SILVA SANTOS, Douglas Arneson, Karthickeyan Chella Krishnan, In Sook Ahn, Graciel Diamante , et al. · 2021

Almost four decades of research suggest a dynamic role of ductal epithelial cells in adipocyte adaptation in mammary gland white adipose tissue (mgWAT), but factors that mediate such communication are not known. Here, we identify a complex…

Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle Open

Patrick J. Ferrara, Xin Rong, J. Alan Maschek, Anthony R.P. Verkerke, Piyarat Siripoksup , et al. · 2021

Aberrant lipid metabolism promotes the development of skeletal muscle insulin resistance, but the exact identity of lipid-mediated mechanisms relevant to human obesity remains unclear. A comprehensive lipidomic analysis of primary myocytes…

Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis Open

Frode Norheim, Karthickeyan Chella Krishnan, Thomas Bjellaas, Laurent Vergnes, Calvin Pan , et al. · 2021

Mammary ductal epithelium controls cold-induced adipocyte thermogenesis Open

LETÍCIA VITÓRIA DA SILVA SANTOS, Douglas Arneson, Alexandra Alvarsson, Karthickeyan Chella Krishnan, Alessia Centzone , et al. · 2020

Sympathetic activation during cold exposure increases adipocyte thermogenesis via expression of mitochondrial protein uncoupling protein 1 (UCP1) 1 . The propensity of adipocytes to express UCP1 is under a critical influence of the adipose…

Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity Open

Rebeca Acı́n-Pérez, Salvador Iborra, Yolanda Martí-Mateos, Emma C. L. Cook, Ruth Conde‐Garrosa , et al. · 2020

Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner Open

Karthickeyan Chella Krishnan, Raquel R. Floyd, Simon Sabir, Dulshan W. Jayasekera, Paola León‐Mimila , et al. · 2020

Incorporation of Unique Molecular Identifiers (UMIs) into Unique Dual Sample Indexing (UDI) Improves the Accuracy of Quantitative NGS Open

Michael J. Cormier, Liu P, Choong Eui Song, D Posfai, Karthickeyan Chella Krishnan , et al. · 2020

The use of Unique Molecular Identifiers has become increasingly popular and offer a multitude of advantages especially when paired with unique dual sample indexing. Two major factors affecting sequencing accuracy are PCR duplication arisin…

The Lands cycle modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle Open

Patrick J. Ferrara, Xin Rong, J. Alan Maschek, Anthony R.P. Verkerke, Piyarat Siripoksup , et al. · 2019

Aberrant lipid metabolism promotes the development of skeletal muscle insulin resistance, but the exact identity of lipid-mediated mechanisms relevant to human obesity remains unclear. A comprehensive lipidomic analyses of primary myocytes…

Differential metabolic and multi-tissue transcriptomic responses to fructose consumption among genetically diverse mice Open

Guanglin Zhang, Hyae Ran Byun, Zhe Ying, Montgomery Blencowe, Yuqi Zhao , et al. · 2019

Sex-specific metabolic functions of adipose Lipocalin-2 Open

Karthickeyan Chella Krishnan, Simon Sabir, Michaël Shum, Yonghong Meng, Rebeca Acı́n-Pérez , et al. · 2019

Following up on our population-based studies, we demonstrate that LCN2 acts in a highly sex- and tissue-specific manner in mice. Our results have important implications for human studies, emphasizing the importance of sex and the tissue so…

Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits Open

Frode Norheim, Yehudit Hasin-Brumshtein, Laurent Vergnes, Karthickeyan Chella Krishnan, Calvin Pan , et al. · 2019

Differential Metabolic and Multi-tissue Transcriptomic Responses to Fructose Consumption among Genetically Diverse Mice Open

Guanglin Zhang, Hyae Ran Byun, Zhe Ying, Montgomery Blencowe, Yuqi Zhao , et al. · 2018

High fructose intake is a major risk for metabolic syndrome; however, its effects seem to vary across individuals. To determine main factors involved in the inter-individual responses to fructose, we fed inbred mouse strains C57BL/6J (B6),…

Sex differences in metabolism and cardiometabolic disorders Open

Karthickeyan Chella Krishnan, Margarete Mehrabian, Aldons J. Lusis · 2018

Purpose of review Sex differences are pervasive in metabolic and cardiovascular traits, yet they have often been ignored in human and animal model research. Sex differences can arise from reversible hormonal effects, from irreversible orga…

The Genetic Architecture of Diet‐Induced Hepatic Fibrosis in Mice Open

Simon T. Hui, Zeyneb Kurt, Iina Tuominen, Frode Norheim, Richard C. Davis , et al. · 2018

We report the genetic analysis of a “humanized” hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis. Mice carrying transgenes for human apolipoprotein E*3‐Leiden and cholesteryl ester transfer protei…

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism Open

Marcus Seldin, Simon Koplev, Prashant Rajbhandari, Laurent Vergnes, Gregory M. Rosenberg , et al. · 2018

Genetic, dietary, and sex-specific regulation of hepatic ceramides and the relationship between hepatic ceramides and IR [S] Open

Frode Norheim, Thomas Bjellaas, Simon T. Hui, Karthickeyan Chella Krishnan, Jakleen Lee , et al. · 2018

Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease Open

Karthickeyan Chella Krishnan, Zeyneb Kurt, Rio Barrere‐Cain, Simon Sabir, Aditi Das , et al. · 2018

The etiology of non-alcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease, is poorly understood. To understand the causal mechanisms underlying NAFLD, we conducted a multi-omics, multi-tissue integrative stud…

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