Karthik Mallela
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View article: Systemic immunosuppression from ultraviolet radiation exposure inhibits cancer immunotherapy
Systemic immunosuppression from ultraviolet radiation exposure inhibits cancer immunotherapy Open
Background Ultraviolet radiation (UVR) affects local cutaneous and systemic immunity acutely. The wavelength, pattern and intensity of UVR exposure, individual skin phototype and immune state of individuals modulate the impact of UVR syste…
View article: Stromal lipid species dictate melanoma metastasis and tropism
Stromal lipid species dictate melanoma metastasis and tropism Open
Cancer cells adapt to signals in the tumor microenvironment (TME), but the TME cues that impact metastasis and tropism are still incompletely understood. We show that abundant stromal lipids from young subcutaneous adipocytes, including ph…
View article: Oncogenic role of MiR-130a in oral squamous cell carcinoma
Oncogenic role of MiR-130a in oral squamous cell carcinoma Open
Aberrant activation of the PI3K/AKT/mTOR pathway is attributed to the pathogenesis of oral squamous cell carcinoma (OSCC). In recent years, increasing evidence suggests the involvement of microRNAs (miRNAs) in oral carcinogenesis by acting…
View article: Oncogenic Role of miR-130a in Oral Squamous Cell Carcinoma
Oncogenic Role of miR-130a in Oral Squamous Cell Carcinoma Open
Aberrant activation of the PI3K/AKT/mTOR pathway is attributed to the pathogenesis of oral squamous cell carcinoma (OSCC). In recent years, increasing evidence suggests the involvement of microRNAs (miRNAs) in oral carcinogenesis by acting…