Karthikeyan Sivaraman
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View article: Large scale analysis of the SARS-CoV-2 main protease reveals marginal presence of nirmatrelvir-resistant SARS-CoV-2 Omicron mutants in Ontario, Canada, December 2021–September 2023
Large scale analysis of the SARS-CoV-2 main protease reveals marginal presence of nirmatrelvir-resistant SARS-CoV-2 Omicron mutants in Ontario, Canada, December 2021–September 2023 Open
The observations suggest that, as of September 2023, no significant or widespread resistance to nirmatrelvir has developed among SARS-CoV-2 Omicron variants in Ontario. This study highlights the importance of creating automated monitoring …
View article: L'analyse à grande échelle de la protéase principale du virus SRAS-CoV-2 révèle la présence marginale de mutants du variant Omicron du SRAS-CoV-2 résistants au nirmatrelvir en Ontario, au Canada, de décembre 2021 à septembre 2023
L'analyse à grande échelle de la protéase principale du virus SRAS-CoV-2 révèle la présence marginale de mutants du variant Omicron du SRAS-CoV-2 résistants au nirmatrelvir en Ontario, au Canada, de décembre 2021 à septembre 2023 Open
View article: Genomic Epidemiology of Large Blastomycosis Outbreak, Ontario, Canada, 2021
Genomic Epidemiology of Large Blastomycosis Outbreak, Ontario, Canada, 2021 Open
Using phylogenomic analysis, we provide genomic epidemiology analysis of a large blastomycosis outbreak in Ontario, Canada, caused by Blastomyces gilchristii. The outbreak occurred in a locale where blastomycosis is rarely diagnosed, signa…
View article: Detection of the novel SARS-CoV-2 European lineage B.1.177 in Ontario, Canada
Detection of the novel SARS-CoV-2 European lineage B.1.177 in Ontario, Canada Open
View article: Detection of the Novel SARS-CoV-2 European Lineage B.1.177 in Ontario, Canada
Detection of the Novel SARS-CoV-2 European Lineage B.1.177 in Ontario, Canada Open
Background Travel-related dissemination of SARS-CoV-2 continues to contribute to the global pandemic. A novel SARS-CoV-2 lineage (B.1.177) reportedly arose in Spain in the summer of 2020, with subsequent spread across Europe linked to trav…
View article: Are shed hair genomes the most effective noninvasive resource for estimating relationships in the wild?
Are shed hair genomes the most effective noninvasive resource for estimating relationships in the wild? Open
Knowledge of relationships in wild populations is critical for better understanding mating systems and inbreeding scenarios to inform conservation strategies for endangered species. To delineate pedigrees in wild populations, study genetic…
View article: Is shed hair the most effective non-invasive resource for estimating wild pedigrees?
Is shed hair the most effective non-invasive resource for estimating wild pedigrees? Open
Wild pedigrees are critical for better understanding mating systems and inbreeding scenarios to inform conservation strategies for endangered species. To delineate pedigrees in wild populations, many identified individuals will have to be …
View article: Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors
Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors Open
Retinoblastoma is a rare pediatric tumor of the retina, caused by the homozygous loss of the Retinoblastoma 1 (RB1) tumor suppressor gene. Previous microarray studies have identified changes in the expression profiles of coding genes; howe…
View article: Unraveling the RNA world of retinoblastoma
Unraveling the RNA world of retinoblastoma Open
Retinoblastoma is the most common primary intraocular tumor in children. It is the first ever cancer to have a genetic basis where inactivation of RB gene in both the alleles would cause the cancer1. Whole genome sequencing, gene expressio…
View article: Sensitive Identification and Quantification of Microbial Species in Metagenomes
Sensitive Identification and Quantification of Microbial Species in Metagenomes Open
Shotgun Metagenomics has emerged as a popular approach for understanding the underlying microbial community composition and metabolic potential in the recent years. Many computational methods have been developed in order decipher the taxon…
View article: Somatic Variations in Cervical Cancers in Indian Patients
Somatic Variations in Cervical Cancers in Indian Patients Open
There are very few reports that describe the mutational landscape of cervical cancer, one of the leading cancers in Indian women. The aim of the present study was to investigate the somatic mutations that occur in cervical cancer. Whole ex…