Kartik S. Pradeepan
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View article: Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics
Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics Open
Cortical neurons in brain slices display intrinsic spike frequency adaptation (I-SFA) to constant current inputs, while extracellular recordings show extrinsic SFA (E-SFA) during sustained visual stimulation. Inferring how I-SFA contribute…
View article: Hypersynchronous iPSC-derived<i>SHANK2</i>neuronal networks are rescued by mGluR5 agonism
Hypersynchronous iPSC-derived<i>SHANK2</i>neuronal networks are rescued by mGluR5 agonism Open
Variants in the gene encoding the postsynaptic scaffolding protein SHANK2 are associated with several neurodevelopmental disorders, including autism spectrum disorder. Here, we used in vitro multielectrode arrays and pharmacological manipu…
View article: Calcium-Dependent Hyperexcitability in Human Stem Cell–Derived Rett Syndrome Neuronal Networks
Calcium-Dependent Hyperexcitability in Human Stem Cell–Derived Rett Syndrome Neuronal Networks Open
View article: Hyperexcitability in human<i>MECP2</i>null neuronal networks manifests as calcium-dependent reverberating super bursts
Hyperexcitability in human<i>MECP2</i>null neuronal networks manifests as calcium-dependent reverberating super bursts Open
Rett syndrome (RTT) patients show abnormal developmental trajectories including loss of language and repetitive hand movements but also have signs of cortical hyperexcitability such as seizures. RTT is predominantly caused by mutations in …
View article: Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations
Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations Open
Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily caused by heterozygous loss-of-function mutations in the X-linked gene MECP2 that is a global transcriptional regulator. Mutations in the methyl-CpG binding domain (MBD)…
View article: Multielectrode Arrays for Functional Phenotyping of Neurons from Induced Pluripotent Stem Cell Models of Neurodevelopmental Disorders
Multielectrode Arrays for Functional Phenotyping of Neurons from Induced Pluripotent Stem Cell Models of Neurodevelopmental Disorders Open
In vitro multielectrode array (MEA) systems are increasingly used as higher-throughput platforms for functional phenotyping studies of neurons in induced pluripotent stem cell (iPSC) disease models. While MEA systems generate large amounts…
View article: Present State of Brain Machine Interfaces
Present State of Brain Machine Interfaces Open