Kaspar F. Bachmann
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View article: Effects of Preoxygenation With Intratracheal Suctioning During Extubation: An Alternating Cluster-Controlled Trial (INtratracheal suctioning and oxygenation AT Extubation [INNOVATE])
Effects of Preoxygenation With Intratracheal Suctioning During Extubation: An Alternating Cluster-Controlled Trial (INtratracheal suctioning and oxygenation AT Extubation [INNOVATE]) Open
OBJECTIVE: Extubation is a critical event for patients in the ICU. Preoxygenation and intratracheal suctioning during extubation may contribute to atelectasis. However, evidence concerning extubation procedures and their impact on patient …
View article: Gastrointestinal function and nutritional interventions in septic shock
Gastrointestinal function and nutritional interventions in septic shock Open
Purpose of review Gastrointestinal (GI) dysfunction significantly impacts patient outcomes in septic shock, complicating clinical management due to its central role in systemic inflammation, barrier integrity, and nutrient assimilation. Th…
View article: The critical role of timely medical emergency team activation in oncological and non-oncological patients
The critical role of timely medical emergency team activation in oncological and non-oncological patients Open
Purpose This study aimed to analyse the impact of time from first physiological derangement (positive Vital Sign Score, VSS) to Medical Emergency Team (MET) activation on mortality in oncological versus non-oncological patients. Methods Al…
View article: Management of acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis
Management of acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis Open
View article: Electrolyte disorders in the critically ill: a retrospective analysis
Electrolyte disorders in the critically ill: a retrospective analysis Open
Several electrolyte disorders have been associated with adverse outcomes, but data on the coincidence of multiple disorders, interactions between different electrolytes and the impact of substitution on electrolyte levels are scarce. This …
View article: Adjunctive Sedation with Dexmedetomidine for the Prevention of Severe Inflammation and Septic Encephalopathy: A Pilot Randomized Controlled Study
Adjunctive Sedation with Dexmedetomidine for the Prevention of Severe Inflammation and Septic Encephalopathy: A Pilot Randomized Controlled Study Open
Objectives: Septic encephalopathy (SE) occurs in up to 50% of critically ill patients with sepsis and is associated with a high mortality and morbidity. The pathophysiology of SE is complex and involves increased levels of inflammatory med…
View article: Core outcome set of daily monitoring of gastrointestinal function in adult critically ill patients: a modified Delphi consensus process (COSMOGI)
Core outcome set of daily monitoring of gastrointestinal function in adult critically ill patients: a modified Delphi consensus process (COSMOGI) Open
This project was registered at ( www.comet-initiative.org ) on 27.03.2023 (number 2609) and was an ESICM-endorsed research project.
View article: The nociceptive withdrawal reflex during spinal analgesia in pigs undergoing veno-arterial extracorporeal membrane oxygenation: a prospective observational study
The nociceptive withdrawal reflex during spinal analgesia in pigs undergoing veno-arterial extracorporeal membrane oxygenation: a prospective observational study Open
Introduction Use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is still in the focus of research, in which pigs are commonly involved. During VA-ECMO, cardiovascular parameters are artificially manipulated and therefore no…
View article: How to define parenteral nutrition
How to define parenteral nutrition Open
View article: Noradrenaline dose cutoffs to characterise the severity of cardiovascular failure: Data‐based development and external validation
Noradrenaline dose cutoffs to characterise the severity of cardiovascular failure: Data‐based development and external validation Open
Background The vasopressor dose needed is a common measure to assess the severity of cardiovascular failure, but there is no consensus on the ranges of vasopressor doses determining different levels of cardiovascular support. We aimed to i…
View article: Mechanisms maintaining right ventricular contractility-to-pulmonary arterial elastance ratio in VA ECMO: a retrospective animal data analysis of RV–PA coupling
Mechanisms maintaining right ventricular contractility-to-pulmonary arterial elastance ratio in VA ECMO: a retrospective animal data analysis of RV–PA coupling Open
View article: Bilateral phrenic nerve block to reduce hazardous respiratory drive in a mechanically ventilated patient with <scp>COVID</scp>‐19—A case report
Bilateral phrenic nerve block to reduce hazardous respiratory drive in a mechanically ventilated patient with <span>COVID</span>‐19—A case report Open
Key Clinical Message Forced inspiration during mechanical ventilation risks self‐inflicted lung injury. However, controlling it with sedation or paralysis may cause polyneuropathy and myopathy. We tested bilateral phrenic nerve paralysis w…
View article: <i>Comment on:</i> “A novel ‘shunt fraction’ method to derive native cardiac output during liberation from central VA ECMO” by Lim, HS
<i>Comment on:</i> “A novel ‘shunt fraction’ method to derive native cardiac output during liberation from central VA ECMO” by Lim, HS Open
We have read with interest the case report by Lim and his recent review of the Fick principle on veno-arterial extracorporeal membrane oxygenation (VA ECMO).1, 2 We are delighted that the measurement of native cardiac output during extraco…
View article: Modified Thermodilution for Simultaneous Cardiac Output and Recirculation Assessment in Veno-venous Extracorporeal Membrane Oxygenation: A Prospective Diagnostic Accuracy Study
Modified Thermodilution for Simultaneous Cardiac Output and Recirculation Assessment in Veno-venous Extracorporeal Membrane Oxygenation: A Prospective Diagnostic Accuracy Study Open
Background Thermodilution is unreliable in veno-venous extracorporeal membrane oxygenation (VV-ECMO). Systemic oxygenation depends on recirculation fractions and ratios of extracorporeal membrane oxygenation (ECMO) flow to cardiac output. …
View article: The Role of Intraoperative and Early Postoperative Blood Pressure Variations, Fluid Balance and Inotropics in Fibula Free Flap Head and Neck Reconstruction: A Retrospective Analysis
The Role of Intraoperative and Early Postoperative Blood Pressure Variations, Fluid Balance and Inotropics in Fibula Free Flap Head and Neck Reconstruction: A Retrospective Analysis Open
Background: In head and neck reconstructive surgery, postoperative complications are a well-known concern. Methods: We examined 46 patients who underwent ablative surgery and received fibula free flap reconstruction. The main focus was to …
View article: Interactions between extracorporeal support and the cardiopulmonary system
Interactions between extracorporeal support and the cardiopulmonary system Open
This review describes the intricate physiological interactions involved in the application of extracorporeal therapy, with specific focus on cardiopulmonary relationships. Extracorporeal therapy significantly influences cardiovascular and …
View article: Cardiopulmonary interactions—which monitoring tools to use?
Cardiopulmonary interactions—which monitoring tools to use? Open
Heart-lung interactions occur due to the mechanical influence of intrathoracic pressure and lung volume changes on cardiac and circulatory function. These interactions manifest as respiratory fluctuations in venous, pulmonary, and arterial…
View article: Behaviour and stability of thermodilution signals in a closed extracorporeal circuit: a bench study
Behaviour and stability of thermodilution signals in a closed extracorporeal circuit: a bench study Open
View article: Current practice of gastric residual volume measurements and related outcomes of critically ill patients: A secondary analysis of the intestinal‐specific organ function assessment study
Current practice of gastric residual volume measurements and related outcomes of critically ill patients: A secondary analysis of the intestinal‐specific organ function assessment study Open
Background Gastric residual volume (GRV) measurement to detect gastrointestinal (GI) dysfunction is a common diagnostic procedures in critical care, albeit still not well standardized being operator‐, patient‐, and tube‐dependent. Our aim …
View article: Integral assessment of gas exchange during veno-arterial ECMO: accuracy and precision of a modified Fick principle in a porcine model
Integral assessment of gas exchange during veno-arterial ECMO: accuracy and precision of a modified Fick principle in a porcine model Open
Assessment of native cardiac output during extracorporeal circulation is challenging. We assessed a modified Fick principle under conditions such as dead space and shunt in 13 anesthetized swine undergoing centrally cannulated veno-arteria…
View article: Reply to La Via and colleagues
Reply to La Via and colleagues Open
View article: The effects of positive end-expiratory pressure on cardiac function: a comparative echocardiography-conductance catheter study
The effects of positive end-expiratory pressure on cardiac function: a comparative echocardiography-conductance catheter study Open
View article: Estimating cardiac output based on gas exchange during veno-arterial extracorporeal membrane oxygenation in a simulation study using paediatric oxygenators
Estimating cardiac output based on gas exchange during veno-arterial extracorporeal membrane oxygenation in a simulation study using paediatric oxygenators Open
View article: Assessment of Right Heart Function during Extracorporeal Therapy by Modified Thermodilution in a Porcine Model
Assessment of Right Heart Function during Extracorporeal Therapy by Modified Thermodilution in a Porcine Model Open
Background Veno-arterial extracorporeal membrane oxygenation therapy is a growing treatment modality for acute cardiorespiratory failure. Cardiac output monitoring during veno-arterial extracorporeal membrane oxygenation therapy remains ch…
View article: Dissociation of Arterial Oxygen Saturation and Oxygen Delivery in VV-ECMO: The Trend Is Your Friend
Dissociation of Arterial Oxygen Saturation and Oxygen Delivery in VV-ECMO: The Trend Is Your Friend Open
View article: Gas exchange calculation may estimate changes in pulmonary blood flow during veno-arterial extracorporeal membrane oxygenation in a porcine model
Gas exchange calculation may estimate changes in pulmonary blood flow during veno-arterial extracorporeal membrane oxygenation in a porcine model Open
Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is used as rescue therapy for severe cardiopulmonary failure. We tested whether the ratio of CO 2 elimination at the lung and the V-A ECMO (V˙co 2ECMO /V˙co 2Lung ) would reflect…
View article: Calculating pulmonary blood flow from CO2 elimination. An in vitro model
Calculating pulmonary blood flow from CO2 elimination. An in vitro model Open
View article: On-site availability of guidelines and standard operating procedures (SOPs): evaluation of a web-based solution in two tertiary level hospitals
On-site availability of guidelines and standard operating procedures (SOPs): evaluation of a web-based solution in two tertiary level hospitals Open
View article: Implementation and Evaluation of a Web-Based Distribution System For Anesthesia Department Guidelines and Standard Operating Procedures: Qualitative Study and Content Analysis
Implementation and Evaluation of a Web-Based Distribution System For Anesthesia Department Guidelines and Standard Operating Procedures: Qualitative Study and Content Analysis Open
Background Digitization is spreading exponentially in medical care, with improved availability of electronic devices. Guidelines and standard operating procedures (SOPs) form an important part of daily clinical routine, and adherence is as…
View article: Pulmonary blood flow on venoarterial (VA) Extracorporeal membrane oxygenation (ECMO): Estimation by gas exchange
Pulmonary blood flow on venoarterial (VA) Extracorporeal membrane oxygenation (ECMO): Estimation by gas exchange Open