Explanipedia

Infection type and short-term mortality in patients with infection-associated disseminated intravascular coagulation: a cohort study Open

Simon Flæng, Asger Granfeldt, Kasper Adelborg, Henrik Toft Sørensen · 2025

Infection-associated DIC had a high short-term mortality, which varied among infection types, thus suggesting that infection type is an important predictor of the clinical course of DIC.

Effect of semaglutide 2.4 mg on use of antihypertensive and lipid‐lowering treatment in five randomized controlled <span>STEP</span> trials Open

Beverly G. Tchang, Michael G. Knight, Kasper Adelborg, Jennifer N. Clements, Aske Thorn Iversen , et al. · 2025

Objective The objective of this study was to assess antihypertensive and lipid‐lowering treatment changes in participants receiving semaglutide 2.4 mg versus placebo across pooled populations from five Semaglutide Treatment Effect in Peopl…

<span>ABO</span> Blood Type and Short‐Term Mortality in Patients With Infection‐Associated Disseminated Intravascular Coagulation Open

Simon Flæng, Asger Granfeldt, Kasper Adelborg, Henrik Toft Sørensen · 2024

Background Disseminated intravascular coagulation (DIC) is a devastating disease of the coagulation system. We examined the association between ABO blood type and short‐term mortality in patients with infection‐associated DIC. Methods The …

The DANish Disseminated Intravascular Coagulation (DANDIC) Cohort Study: Time Trends in Incidence and Short-Term Mortality Open

Simon Flæng, Asger Granfeldt, Henrik Toft Sørensen, Kasper Adelborg · 2024

Background: Disseminated intravascular coagulation (DIC) is a severe condition affecting the coagulation system. However, current knowledge regarding its incidence and mortality remains limited. In this study, we examined the incidence and…

Considerations for the use of biochemical laboratory registry data in clinical and public health research Open

Lasse M. Obel, Kasper Adelborg, Anton Pottegård, Henrik Toft Sørensen, Mads Nybo · 2024

Risk and adverse clinical outcomes of thrombocytopenia among patients with solid tumors—a Danish population-based cohort study Open

Kasper Adelborg, Katalin Veres, Erzsébet Horváth–Puhó, Mary C. Clouser, Hossam Saad , et al. · 2024

Background Knowledge about thrombocytopenia among patients with solid tumors is scarce. We examined the risk of thrombocytopenia among patients with solid tumors and its association with adverse outcomes. Methods Using Danish health regist…

Oral anticoagulant treatment and risk of kidney disease—a nationwide, population-based cohort study Open

Ane Emilie Friis Vestergaard, Simon Kok Jensen, Uffe Heide‐Jørgensen, Kasper Adelborg, Henrik Birn , et al. · 2023

Background Direct oral anticoagulants (DOACs) are recommended as first-line treatment of atrial fibrillation. Whether DOAC use is associated with lower risks of kidney complications compared with vitamin K antagonists (VKAs) remains unclea…

High-intensity versus moderate-intensity statin treatment for patients with ischemic stroke: Nationwide cohort study Open

Frederikke Bach, Nils Skajaa, Buket Öztürk Esen, Cecilia Hvitfeldt Fuglsang, Erzsébet Horváth–Puhó , et al. · 2023

Purpose: Guidelines recommend high-intensity statin treatment after ischemic stroke, but evidence is sparse on the effectiveness and safety of different statin treatment intensities. We examined effectiveness and safety outcomes among pati…

Preadmission Opioid Use and 1‐Year Mortality Following Incident Myocardial Infarction: A Danish Population‐Based Cohort Study (1997–2016) Open

Søren Korsgaard, Troels Munch, Erzsébet Horváth–Puhó, Kasper Adelborg, Christian Fynbo Christiansen , et al. · 2023

Background Opioid use has been linked to an increased risk of myocardial infarction and cardiovascular mortality, but the prognostic impact of opioid use before an incident myocardial infarction is largely unknown. Methods and Results We c…

Labour market participation and retirement after stroke in Denmark: registry based cohort study Open

Nils Skajaa, Kasper Adelborg, Erzsébet Horváth–Puhó, Kenneth J. Rothman, Victor W. Henderson , et al. · 2023

Objective To examine labour market participation and retirement among patients with stroke and matched people in the general population according to stroke subtype. Design Nationwide, population based, matched cohort study. Setting Danish …

In vitro Effect of Dalteparin and Argatroban on Hemostasis in Critically Ill Sepsis Patients with New-Onset Thrombocytopenia Open

Søren Nygaard, Christine Lodberg Hvas, Anne‐Mette Hvas, Kasper Adelborg · 2022

Thrombocytopenia is common among critically ill sepsis patients, while they also hold an increased risk for thromboembolic events. Thus, the choice of anticoagulant prophylaxis for this patient population is challenging. We investigated th…

Validation of safety outcomes in routinely collected data: Lessons learned from a multinational postapproval safety study Open

Patrick J. Arena, Kui Huang, Lukas Löfling, Shahram Bahmanyar, Jingping Mo , et al. · 2022

Thromboembolic events, bleeding, and mortality in patients with cerebral venous thrombosis: a nationwide cohort study Open

Nils Skajaa, Jan P. Vandenbroucke, Claus Z. Simonsen, Henrik Toft Sørensen, Kasper Adelborg · 2022

Cerebral venous thrombosis (CVT) predominantly affects young to middle-aged women. Scarce data exist regarding the long-term prognosis. We examined the clinical course of patients with CVT overall and according to their age and sex. Using …

Exploring the epidemiology of disseminated intravascular coagulation: protocol for the DANish Disseminated Intravascular Coagulation (DANDIC) Cohort Study Open

Simon Flæng, Søren Nygaard, Asger Granfeldt, Anne‐Mette Hvas, Henrik Toft Sørensen , et al. · 2022

Introduction Since disseminated intravascular coagulation (DIC) was first described, it has been considered a serious disease of the coagulation system and a major challenge to clinicians. Currently, several important knowledge gaps remain…

Evaluation of Neurologic and Psychiatric Outcomes After Hospital Discharge Among Adult Survivors of Cardiac Arrest Open

Niels H. Secher, Kasper Adelborg, Péter Szentkúti, Christian Fynbo Christiansen, Asger Granfeldt , et al. · 2022

In this cohort study, patients discharged after cardiac arrest had an increased rate of subsequent stroke, epilepsy, dementia, depression, and anxiety compared with patients with myocardial infarction and people from the general population…

High-sensitivity troponin T and I in patients suspected of acute myocardial infarction Open

Steffan Kleemeier, Anders Abildgaard, Søren Ladefoged, Jacob Thorsted Sørensen, Carsten Stengaard , et al. · 2022

Measurement of cardiac troponin (cTn) is the cornerstone in the diagnosis of myocardial infarction (MI). Potential disparities in concentrations of cTn, trajectories and mortality, following initial measurement warrant further investigatio…

Atrial fibrillation, liver cirrhosis, thrombosis, and bleeding: A Danish population‐based cohort study Open

Emil Zâl Bjerregaard Riahi, Kasper Adelborg, Lars Pedersen, Søren Risom Kristensen, Anette Tarp Hansen , et al. · 2022

Pragmatic Trial End Point Capture: Making Sure Makes the Difference Open

Jens Sundbøll, Kasper Adelborg · 2021

Disseminated intravascular coagulation diagnosis: Positive predictive value of the ISTH score in a Danish population Open

Julie Brogaard Larsen, Mathies Appel Aggerbeck, Asger Granfeldt, Morten Schmidt, Anne‐Mette Hvas , et al. · 2021

The accuracy of ISTH DIC score ≥5 was moderate for overt DIC but increased with increasing scores and depended on the underlying cause of DIC. This new knowledge provides guidance to physicians and enables DIC research using laboratory-bas…

Dynamic Hemostasis and Fibrinolysis Assays in Intensive Care COVID-19 Patients and Association with Thrombosis and Bleeding—A Systematic Review and a Cohort Study Open

Christine Lodberg Hvas, Julie Brogaard Larsen, Kasper Adelborg, Steffen Christensen, Anne‐Mette Hvas · 2021

Patients admitted to the intensive care unit (ICU) with coronavirus disease 2019 (COVID-19), the infectious pathology caused by severe acute respiratory syndrome coronavirus 2, have a high risk of thrombosis, though the precise mechanisms …

WSO Congress supplement Open

Nils Skajaa, Kasper Adelborg, Erzsébet Horváth–Puhó, Kenneth J. Rothman, V. Henderson , et al. · 2021

Background and Aims: Urgent ambulant care is recommended following suspected TIA, but unintended consequences including ED re-presentations are poorly investigated. We aimed to assess the effects of an ambulatory care pathway following eme…

Cardiovascular events in cancer patients with bone metastases—A Danish population‐based cohort study of 23,113 patients Open

Peter H. Asdahl, Jens Sundbøll, Kasper Adelborg, Thomas Bøjer Rasmussen, Anouchka Seesaghur , et al. · 2021

Introduction The incidence of cardiovascular events among cancer patients with bone metastases is poorly understood. We examined rates of cardiovascular events among cancer patients with bone metastases and mortality following such events.…

The Danish Myelodysplastic Syndromes Database: Patient Characteristics and Validity of Data Records Open

Lauritsen TB, Nørgaard JM, Kirsten Grønbæk, Vallentin AP, Ahmad SA , et al. · 2021

Tine Bichel Lauritsen,1 Jan Maxwell Nørgaard,1 Kirsten Grønbæk,2– 4 Anders Pommer Vallentin,5 Syed Azhar Ahmad,6 Louise Hur Hannig,7 Marianne Tang Severinsen,8,9 Kasper Adelborg,10,11 Lene Sofie Granfeldt Østgård11,12 1Department of Hemato…

The Danish Myelodysplastic Syndromes Database: Patient Characteristics and Validity of Data Records Open

Tine Bichel Lauritsen, Jan Maxwell Nørgaard, Kirsten Grønbæk, Anders Pommer Vallentin, Syed Azhar Ahmad , et al. · 2021

In this study, there was a high accuracy of recorded data and a low proportion of missing data. Thus, the DMDSD serves as a valuable data source for future epidemiological studies on MDS.

Disseminated intravascular coagulation: epidemiology, biomarkers, and management Open

Kasper Adelborg, Julie Brogaard Larsen, Anne‐Mette Hvas · 2021

Summary Disseminated intravascular coagulation (DIC) is a systemic activation of the coagulation system, which results in microvascular thrombosis and, simultaneously, potentially life‐threatening haemorrhage attributed to consumption of p…

Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study Open

Jens Sundbøll, Szimonetta Komjáthiné Szépligeti, Kasper Adelborg, Péter Szentkúti, Hans Gregersen , et al. · 2020

Objectives To assess the risks of myocardial infarction, stroke, peripheral artery disease, venous thromboembolism, atrial fibrillation or atrial flutter and heart failure in patients with constipation compared with a general population co…

Risk of primary gastrointestinal cancers following incident non-metastatic breast cancer: a Danish population-based cohort study Open

Kasper Adelborg, Dóra Körmendiné Farkas, Jens Sundbøll, Lidia Schapira, Suzanne Tamang , et al. · 2020

Objective We examined the risk of primary gastrointestinal cancers in women with breast cancer and compared this risk with that of the general population. Design Using population-based Danish registries, we conducted a cohort study of wome…

Existing Data Sources in Clinical Epidemiology: Laboratory Information System Databases in Denmark Open

Arendt JFH, Hansen AT, Ladefoged SA, Sørensen Ht, Lars Pedersen , et al. · 2020

Johan Frederik Håkonsen Arendt,1,2 Anette Tarp Hansen,1,3 Søren Andreas Ladefoged,2 Henrik Toft Sørensen,1 Lars Pedersen,1 Kasper Adelborg1,2 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Department of…

Existing Data Sources in Clinical Epidemiology: Laboratory Information System Databases in Denmark Open

Johan Frederik Håkonsen Arendt, Anette Tarp Hansen, Søren Ladefoged, Henrik Toft Sørensen, Lars Pedersen , et al. · 2020

Routine biomarker results from hospital laboratory information systems, covering hospitals and general practitioners, in Denmark are available to researchers through access to the regional Clinical Laboratory Information System Research Da…

Comorbidity and risk of venous thromboembolism after hospitalization for first‐time myocardial infarction: A population‐based cohort study Open

Morten Würtz, Erik Lerkevang Grove, Priscila Corraini, Kasper Adelborg, Jens Sundbøll , et al. · 2020

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