Kassi T. Stein
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View article: Kinetic modeling of H2O2 dynamics in the mitochondria of HeLa cells
Kinetic modeling of H2O2 dynamics in the mitochondria of HeLa cells Open
Hydrogen peroxide (H2O2) promotes a range of phenotypes depending on its intracellular concentration and dosing kinetics, including cell death. While this qualitative relationship has been well established, the quantitative and mechanistic…
View article: A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/− rats
A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/− rats Open
27 part 6, pages 337-354.The error relates to the artwork of Table 1 on page 346, in which the units were given in micromoles per milligram of tissue, when the units should have been given in nanomoles per milligram of tissue.
View article: A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/− rats
A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/− rats Open
Tumors caused by loss-of-function mutations in genes encoding TCA cycle enzymes have been recently discovered and are now of great interest. Mutations in succinate dehydrogenase (SDH) subunits cause pheochromocytoma/paraganglioma (PCPG) an…
View article: Methodologies for the mechanistic study of compartment-specific hydrogen peroxide perturbations
Methodologies for the mechanistic study of compartment-specific hydrogen peroxide perturbations Open
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
View article: Mitochondrial H₂O₂ Generation Using a Tunable Chemogenetic Tool To Perturb Redox Homeostasis in Human Cells and Induce Cell Death
Mitochondrial H₂O₂ Generation Using a Tunable Chemogenetic Tool To Perturb Redox Homeostasis in Human Cells and Induce Cell Death Open
Among reactive oxygen species (ROS), H₂O₂ alone acts as a signaling molecule that promotes diverse phenotypes depending on the intracellular concentration. Mitochondria have been suggested as both sources and sinks of cellular H₂O₂, and mi…
View article: A unique model for SDH-deficient GIST: an endocrine-related cancer
A unique model for SDH-deficient GIST: an endocrine-related cancer Open
We describe a unique patient-derived xenograft (PDX) and cell culture model of succinate dehydrogenase-deficient gastrointestinal stromal tumor (SDH-deficient GIST), a rare mesenchymal tumor that can occur in association with paraganglioma…
View article: Interpreting Heterogeneity in Response of Cells Expressing a Fluorescent Hydrogen Peroxide Biosensor
Interpreting Heterogeneity in Response of Cells Expressing a Fluorescent Hydrogen Peroxide Biosensor Open