Katalin E. Kövér
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View article: Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants
Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants Open
Rapamycin (sirolimus), a macrolide compound isolated from the bacterium Streptomyces hygroscopicus , is widely used as oral medication for the prevention of transplant rejection and the treatment of lymphangioleiomyomatosis. It is also inc…
View article: Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants
Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants Open
Rapamycin (sirolimus), a macrolide compound isolated from the bacterium Streptomyces hygroscopicus, is widely used as oral medication for the prevention of transplant rejection and the treatment of lymphangioleiomyomatosis. It is also inco…
View article: Reviewer #1 (Public Review): Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants
Reviewer #1 (Public Review): Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants Open
Rapamycin (sirolimus), a macrolide compound isolated from the bacterium Streptomyces hygroscopicus, is widely used as oral medication for the prevention of transplant rejection and the treatment of lymphangioleiomyomatosis. It is also inco…
View article: Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants
Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants Open
Rapamycin (sirolimus), a macrolide compound isolated from the bacterium Streptomyces hygroscopicus, is widely used as oral medication for the prevention of transplant rejection and the treatment of lymphangioleiomyomatosis. It is also inco…
View article: Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants
Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants Open
Rapamycin (sirolimus), a macrolide compound isolated from the bacterium Streptomyces hygroscopicus, is widely used as oral medication for the prevention of transplant rejection and the treatment of lymphangioleiomyomatosis. It is also inco…
View article: Reviewer #3 (Public Review): Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants
Reviewer #3 (Public Review): Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants Open
Rapamycin (sirolimus), a macrolide compound isolated from the bacterium Streptomyces hygroscopicus, is widely used as oral medication for the prevention of transplant rejection and the treatment of lymphangioleiomyomatosis. It is also inco…
View article: Reviewer #2 (Public Review): Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants
Reviewer #2 (Public Review): Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants Open
Rapamycin (sirolimus), a macrolide compound isolated from the bacterium Streptomyces hygroscopicus, is widely used as oral medication for the prevention of transplant rejection and the treatment of lymphangioleiomyomatosis. It is also inco…
View article: Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants
Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants Open
Rapamycin (sirolimus), a macrolide compound isolated from the bacterium Streptomyces hygroscopicus , is widely used as oral medication for the prevention of transplant rejection and the treatment of lymphangioleiomyomatosis. It is also inc…
View article: CCDC 2210410: Experimental Crystal Structure Determination
CCDC 2210410: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2210409: Experimental Crystal Structure Determination
CCDC 2210409: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2210411: Experimental Crystal Structure Determination
CCDC 2210411: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2210408: Experimental Crystal Structure Determination
CCDC 2210408: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Front Cover Picture: Multifaceted Domino Knoevenagel‐Cyclization Reactions; Four Movements for 2<i>H</i>‐Chromenes and Chromans (Adv. Synth. Catal. 19/2023)
Front Cover Picture: Multifaceted Domino Knoevenagel‐Cyclization Reactions; Four Movements for 2<i>H</i>‐Chromenes and Chromans (Adv. Synth. Catal. 19/2023) Open
The front cover illustrates the diastereoselective formation of condensed heterocyclic ring systems by domino reaction sequences. The dominoes toppling each other represent the steps of the reaction sequences, each transformation initiatin…
View article: Multifaceted Domino Knoevenagel‐Cyclization Reactions; Four Movements for 2<i>H</i>‐Chromenes and Chromans
Multifaceted Domino Knoevenagel‐Cyclization Reactions; Four Movements for 2<i>H</i>‐Chromenes and Chromans Open
Domino Knoevenagel‐cyclization reactions of 2 H ‐chromene and chroman derivatives containing o ‐formylaryl amine or ether side‐chain was carried out to produce four series of chiral condensed heterocycles representing four novel skeletons …
View article: Phosphorylated Peptide Derived from the Myosin Phosphatase Target Subunit Is a Novel Inhibitor of Protein Phosphatase-1
Phosphorylated Peptide Derived from the Myosin Phosphatase Target Subunit Is a Novel Inhibitor of Protein Phosphatase-1 Open
Identification of specific protein phosphatase-1 (PP1) inhibitors is of special importance regarding the study of its cellular functions and may have therapeutic values in diseases coupled to signaling processes. In this study, we prove th…
View article: Alternatively spliced exon regulates context-dependent MEF2D higher-order assembly during myogenesis
Alternatively spliced exon regulates context-dependent MEF2D higher-order assembly during myogenesis Open
Molecular dynamics data on four MEF2D beta-domain peptide constructs.
View article: Alternatively spliced exon regulates context-dependent MEF2D higher-order assembly during myogenesis
Alternatively spliced exon regulates context-dependent MEF2D higher-order assembly during myogenesis Open
Molecular dynamics data on four MEF2D beta-domain peptide constructs.
View article: DMSO-Induced Unfolding of the Antifungal Disulfide Protein PAF and Its Inactive Variant: A Combined NMR and DSC Study
DMSO-Induced Unfolding of the Antifungal Disulfide Protein PAF and Its Inactive Variant: A Combined NMR and DSC Study Open
PAF and related antifungal proteins are promising antimicrobial agents. They have highly stable folds around room temperature due to the presence of 3–4 disulfide bonds. However, unfolded states persist and contribute to the thermal equili…
View article: A Fucosylated Lactose-Presenting Tetravalent Glycocluster Acting as a Mutual Ligand of Pseudomonas aeruginosa Lectins A (PA-IL) and B (PA-IIL)—Synthesis and Interaction Studies
A Fucosylated Lactose-Presenting Tetravalent Glycocluster Acting as a Mutual Ligand of Pseudomonas aeruginosa Lectins A (PA-IL) and B (PA-IIL)—Synthesis and Interaction Studies Open
The Gram-negative bacterium Pseudomonas aeruginosa is an important opportunistic human pathogen associated with cystic fibrosis. P. aeruginosa produces two soluble lectins, the d-galactose-specific lectin PA-IL (LecA) and the l-fucose-spec…
View article: Ultrahigh-Resolution Homo- and Heterodecoupled <sup>1</sup>H and TOCSY NMR Experiments
Ultrahigh-Resolution Homo- and Heterodecoupled <sup>1</sup>H and TOCSY NMR Experiments Open
The original homonuclear decoupled (pure shift) experiments provide ultrahigh-resolution 1H spectra of compounds containing NMR-active heteronuclei of low natural isotopic abundance (e.g., 13C or 15N). In contrast, molecules containing hig…
View article: Four-in-one: HSQC, HSQC-TOCSY (or H2BC), TOCSY, and enhanced HMBC spectra integrated into a single NO Relaxation Delay (NORD) NMR experiment
Four-in-one: HSQC, HSQC-TOCSY (or H2BC), TOCSY, and enhanced HMBC spectra integrated into a single NO Relaxation Delay (NORD) NMR experiment Open
The NMR pulse sequence design strategy of NORD (NO Relaxation Delay) is extended to design of two new three-module experiments, NORD {HMBC}-{HSQC-TOCSY}-{TOCSY} and NORD {HMBC}-{2BOB}-{TOCSY}, each delivering four spectra - HMBC, HSQC, TOC…
View article: Investigation of the Molecular Details of the Interactions of Selenoglycosides and Human Galectin-3
Investigation of the Molecular Details of the Interactions of Selenoglycosides and Human Galectin-3 Open
Human galectin-3 (hGal-3) is involved in a variety of biological processes and is implicated in wide range of diseases. As a result, targeting hGal-3 for clinical applications has become an intense area of research. As a step towards the d…
View article: 77Se-Enriched Selenoglycoside Enables Significant Enhancement in NMR Spectroscopic Monitoring of Glycan–Protein Interactions
77Se-Enriched Selenoglycoside Enables Significant Enhancement in NMR Spectroscopic Monitoring of Glycan–Protein Interactions Open
Detailed investigation of ligand–protein interactions is essential for better understanding of biological processes at the molecular level. Among these binding interactions, the recognition of glycans by lectins is of particular importance…
View article: The First Dimeric Derivatives of the Glycopeptide Antibiotic Teicoplanin
The First Dimeric Derivatives of the Glycopeptide Antibiotic Teicoplanin Open
Various dimeric derivatives of the glycopeptide antibiotic teicoplanin were prepared with the aim of increasing the activity of the parent compound against glycopeptide-resistant bacteria, primarily vancomycin-resistant enterococci. Starti…
View article: Silica@zirconia Core@shell Nanoparticles for Nucleic Acid Building Block Sorption
Silica@zirconia Core@shell Nanoparticles for Nucleic Acid Building Block Sorption Open
The development of delivery systems for the immobilization of nucleic acid cargo molecules is of prime importance due to the need for safe administration of DNA or RNA type of antigens and adjuvants in vaccines. Nanoparticles (NP) in the s…
View article: NORD: NO Relaxation Delay NMR Spectroscopy
NORD: NO Relaxation Delay NMR Spectroscopy Open
The novel concept of NORD ( NO r elaxation d elay) NMR spectroscopy is introduced. The idea is to design concatenated experiments in a way that the magnetization used in the first relaxes toward equilibrium during the second and vice versa…