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View article: Kisspeptin-13 induces hyperalgesia and modulates the expression of opioid and glutamate receptors in mice
Kisspeptin-13 induces hyperalgesia and modulates the expression of opioid and glutamate receptors in mice Open
Kisspeptins are hypothalamic neuropeptides well known for their role in reproductive biology. Our previous results have demonstrated that kisspeptin-13 (KP-13) has pronociceptive and anti-opioid effects. In our present experiments, we inve…
View article: Role of the kisspeptin-KISS1R axis in the pathogenesis of chronic kidney disease and uremic cardiomyopathy
Role of the kisspeptin-KISS1R axis in the pathogenesis of chronic kidney disease and uremic cardiomyopathy Open
The prevalence of chronic kidney disease (CKD) is increasing globally, especially in elderly patients. Uremic cardiomyopathy is a common cardiovascular complication of CKD, characterized by left ventricular hypertrophy (LVH), diastolic dys…
View article: Chronic kidney disease may evoke anxiety by altering CRH expression in the amygdala and tryptophan metabolism in rats
Chronic kidney disease may evoke anxiety by altering CRH expression in the amygdala and tryptophan metabolism in rats Open
Chronic kidney disease (CKD) is associated with anxiety; however, its exact mechanism is not well understood. Therefore, the aim of the present study was to assess the effect of moderate CKD on anxiety in rats. 5/6 nephrectomy was performe…
View article: A Brain Region-Dependent Alteration in the Expression of Vasopressin, Corticotropin-Releasing Factor, and Their Receptors Might Be in the Background of Kisspeptin-13-Induced Hypothalamic-Pituitary-Adrenal Axis Activation and Anxiety in Rats
A Brain Region-Dependent Alteration in the Expression of Vasopressin, Corticotropin-Releasing Factor, and Their Receptors Might Be in the Background of Kisspeptin-13-Induced Hypothalamic-Pituitary-Adrenal Axis Activation and Anxiety in Rats Open
Previously, we reported that intracerebroventricularly administered kisspeptin-13 (KP-13) induces anxiety-like behavior and activates the hypothalamic-pituitary-adrenal (HPA) axis in rats. In the present study, we aimed to shed light on th…
View article: The kisspeptin-1 receptor antagonist peptide-234 aggravates uremic cardiomyopathy in a rat model
The kisspeptin-1 receptor antagonist peptide-234 aggravates uremic cardiomyopathy in a rat model Open
View article: Chronic kidney disease may evoke anxiety by altering CRH expression in the amygdala and tryptophan metabolism in rats
Chronic kidney disease may evoke anxiety by altering CRH expression in the amygdala and tryptophan metabolism in rats Open
Chronic kidney disease (CKD) is associated with anxiety; however, its exact mechanism is not well understood. Therefore, the aim of the present study was to assess the effect of moderate CKD on anxiety in rats. 5/6 nephrectomy was performe…
View article: The Effects of Alcohol Intoxication and Withdrawal on Hypothalamic Neurohormones and Extrahypothalamic Neurotransmitters
The Effects of Alcohol Intoxication and Withdrawal on Hypothalamic Neurohormones and Extrahypothalamic Neurotransmitters Open
The aim of the present study was to determine the effects of alcohol intoxication and withdrawal on hypothalamic neurohormones such as corticotropin-releasing factor (CRF) and arginine vasopressin (AVP), and extrahypothalamic neurotransmit…
View article: Kisspeptin-8 Induces Anxiety-Like Behavior and Hypolocomotion by Activating the HPA Axis and Increasing GABA Release in the Nucleus Accumbens in Rats
Kisspeptin-8 Induces Anxiety-Like Behavior and Hypolocomotion by Activating the HPA Axis and Increasing GABA Release in the Nucleus Accumbens in Rats Open
Kisspeptins (Kp) are RF-amide neuropeptide regulators of the reproductive axis that also influence anxiety, locomotion, and metabolism. We aimed to investigate the effects of intracerebroventricular Kp-8 (an N-terminally truncated octapept…