Katalin Kristó
YOU?
Author Swipe
View article: The Development and Characterization of Layered Pellets Containing a Combination of Amorphized Amlodipine Besylate and Hydrochlorothiazide Using a High-Shear Granulator
The Development and Characterization of Layered Pellets Containing a Combination of Amorphized Amlodipine Besylate and Hydrochlorothiazide Using a High-Shear Granulator Open
Background/Objective: The high-shear granulator is considered an effective piece of equipment for layering pelletization because it enhances drug amorphization and improves drug dissolution. This study aimed to apply a high-shear granulato…
View article: Mesoporous Silica Nanoparticles as Drug Delivery Systems
Mesoporous Silica Nanoparticles as Drug Delivery Systems Open
Mesoporous silica nanocarriers (MSNs) have emerged as significant candidates in the pharmaceutical industry for drug delivery systems, suitable for a wide variety of drugs. Absorbing the active pharmaceutical ingredients (APIs) into the po…
View article: Development and characterization of pramipexole dihydrochloride buccal films for Parkinson’s disease treatment
Development and characterization of pramipexole dihydrochloride buccal films for Parkinson’s disease treatment Open
Parkinson’s disease is one of the most common neurodegenerative diseases worldwide. Swallowing difficulties present a significant challenge in the treatment of Parkinson’s disease patients. Our current experimental work aimed to produce an…
View article: Behavior of Aqueous Medicated Inks on Porous Tablet Surfaces
Behavior of Aqueous Medicated Inks on Porous Tablet Surfaces Open
Background/Objectives: Although technology has progressed and novel dosage forms have been developed, tablets are still the most used form of medication. However, the present manufacturing methods of these oral solid dosage forms offer lim…
View article: Exploring the interconnected properties of cannabidiol suspensions and orodispersible films
Exploring the interconnected properties of cannabidiol suspensions and orodispersible films Open
View article: Cutting-Edge Approaches in the Co-Amorphization Process
Cutting-Edge Approaches in the Co-Amorphization Process Open
Background: Recently, the co-amorphization method has been widely used to refine the bioavailability characteristics of poorly soluble drugs in addition to overcoming the drawbacks of other traditional amorphization techniques. Objectives:…
View article: Lipid-Polymer Hybrid Nanoparticles as a Smart Drug Delivery System for Peptide/Protein Delivery
Lipid-Polymer Hybrid Nanoparticles as a Smart Drug Delivery System for Peptide/Protein Delivery Open
The efficient oral delivery of therapeutic proteins and peptides poses a tremendous challenge due to their inherent instability, large molecular size, and susceptibility to enzymatic degradation. Several nanocarrier systems, such as liposo…
View article: Development and Optimization of Chitosan-Ascorbate-Based Mucoadhesive Films for Buccal Delivery of Captopril
Development and Optimization of Chitosan-Ascorbate-Based Mucoadhesive Films for Buccal Delivery of Captopril Open
Background: Captopril (CAP), an angiotensin-converting enzyme inhibitor (ACEI), is widely prescribed for managing hypertension, heart failure, and related conditions. When administered orally, CAP undergoes hepatic metabolism, resulting in…
View article: Study of the Effect of Temperature on the Production of Carrageenan-Based Buccal Films and Optimization of the Process Parameters
Study of the Effect of Temperature on the Production of Carrageenan-Based Buccal Films and Optimization of the Process Parameters Open
Background/Objectives: Films in the mouth offer a promising alternative drug delivery system for oral administration, with several advantages over traditional oral formulations. Furthermore, their non-invasive nature and easy administratio…
View article: Investigation of the Electrokinetic Potential of Granules and Optimization of the Pelletization Method Using the Quality by Design Approach
Investigation of the Electrokinetic Potential of Granules and Optimization of the Pelletization Method Using the Quality by Design Approach Open
The preparation of pellets using a high-shear granulator in a rapid single-step is considered a good economic alternative to the extrusion spheronization process. As process parameters and material attributes greatly affect pellet qualitie…
View article: Aspects and Implementation of Pharmaceutical Quality by Design
Aspects and Implementation of Pharmaceutical Quality by Design Open
The introduction of the Quality by Design concept in 2004 has brought a paradigm shift in the pharmaceutical industry as well as a new era in pharmaceutical research and development [...]
View article: QbD Approach-Based Preparation and Optimization of Hydrophobic Ion-Pairing Complex of Lysozyme with Sodium Dodecyl Sulphate to Enhance Stability in Lipid-Based Carriers
QbD Approach-Based Preparation and Optimization of Hydrophobic Ion-Pairing Complex of Lysozyme with Sodium Dodecyl Sulphate to Enhance Stability in Lipid-Based Carriers Open
Hydrophobic ion pairing (HIP) complexation was found to be an efficient approach in modulating the release and enhancing the stability and encapsulation of hydrophilic macromolecules such as proteins in hydrophobic nano/microcarriers. The …
View article: Application of QbD Principles in Hydrophobic-Ion PairingComplexation of Proteins
Application of QbD Principles in Hydrophobic-Ion PairingComplexation of Proteins Open
View article: Formulation and investigation of chitosan ascorbate mucoadhesive buccal films
Formulation and investigation of chitosan ascorbate mucoadhesive buccal films Open
View article: Mesoporous silica nanoparticles as drug delivery systems
Mesoporous silica nanoparticles as drug delivery systems Open
View article: High shear granulation as a promising technique in the direct pelletization process
High shear granulation as a promising technique in the direct pelletization process Open
View article: Quality by Design-Guided Systematic Development and Optimization of Mucoadhesive Buccal Films
Quality by Design-Guided Systematic Development and Optimization of Mucoadhesive Buccal Films Open
Mucoadhesive buccal films have found increased popularity in pharmaceutical drug delivery due to the several advantages that they possess. The present study strives to develop and optimize chitosan-based mucoadhesive buccal films by relyin…
View article: Step by Step Preparation and Optimization of Lysozyme Hydrophobic Ion Pairing Complex
Step by Step Preparation and Optimization of Lysozyme Hydrophobic Ion Pairing Complex Open
View article: Formulation and characterization of pramipexole containing buccal films for using in Parkinson's disease
Formulation and characterization of pramipexole containing buccal films for using in Parkinson's disease Open
Parkinson's disease (PD) is neurodegenerative chronic illness which affects primarily the elderly over 45 years of age. The symptoms can be various, both non-motor and motor symptoms can appear. The biggest problem in the treatment of the …
View article: Quality by Design-Based Development of Solid Self-Emulsifying Drug Delivery System (SEDDS) as a Potential Carrier for Oral Delivery of Lysozyme
Quality by Design-Based Development of Solid Self-Emulsifying Drug Delivery System (SEDDS) as a Potential Carrier for Oral Delivery of Lysozyme Open
For many years, researchers have been making efforts to find a manufacturing technique, as well as a drug delivery system, that will allow for oral delivery of biopharmaceuticals to their target site of action without impairing their biolo…
View article: Formulation and investigation of buccal mucoadhesive films forimproving buccal absorption
Formulation and investigation of buccal mucoadhesive films forimproving buccal absorption Open
View article: Formulation of buccal films in Parkinson’s disease
Formulation of buccal films in Parkinson’s disease Open
View article: Gum arabic as novel lysozyme carrier polymer
Gum arabic as novel lysozyme carrier polymer Open
Pharmaceutically, natural carbohydrate polymers have been increased attention, particularly in the field of drug technology, as carrier systems for the reason of their approved safety, biocompatibility, and biodegradability [1].The present…
View article: Application of Pro-CepT granulator for direct pelletization process
Application of Pro-CepT granulator for direct pelletization process Open
The employment of a fast one-step pelletization process by a high-shear granulator with an accurate optimization of all the process variables for the preparation of rounded pellets with required physical properties is considered a good alt…
View article: Preparation and optimization of hydrophobic ion pairing complex oflysozyme
Preparation and optimization of hydrophobic ion pairing complex oflysozyme Open
View article: Determination of design space for direct pelletization using ProCepTgranulator
Determination of design space for direct pelletization using ProCepTgranulator Open
The high shear granulator is one of most common devices used as an alternative pelletization technique for extrusion spheronization to produce pellets with good flowability, compressibility and bulk density.It is also a rapid process with …
View article: Stability, Permeability and Cytotoxicity of Buccal Films in Allergy Treatment
Stability, Permeability and Cytotoxicity of Buccal Films in Allergy Treatment Open
Oral mucoadhesive systems, such as polymer films, are among innovative pharmaceutical products. These systems can be applied in swallowing problems and can also be used in geriatrics and paediatrics. In our earlier work, we successfully fo…
View article: Development and evaluation of bioadhesive buccal films based on sodium alginate for allergy therapy
Development and evaluation of bioadhesive buccal films based on sodium alginate for allergy therapy Open
Buccal drug administration is a less explored area, therefore researchers and companies focus on its research because of its innovative potential and opportunities. Buccal polymer films (patches) are considered to be an innovative form and…
View article: Recent insight into strategies for the design of antimicrobial peptides (AMPs)
Recent insight into strategies for the design of antimicrobial peptides (AMPs) Open
With the increasing development of antibiotic resistance among key bacterial pathogens, there is an urgent need to discover novel classes of antibiotics. Although antimicrobial peptides (AMP) with their specific mode of action are consider…
View article: Investigation of Surface Properties and Free Volumes of Chitosan-Based Buccal Mucoadhesive Drug Delivery Films Containing Ascorbic Acid
Investigation of Surface Properties and Free Volumes of Chitosan-Based Buccal Mucoadhesive Drug Delivery Films Containing Ascorbic Acid Open
Nowadays, the buccal administration of mucoadhesive films is very promising. Our aim was to prepare ascorbic acid-containing chitosan films to study the properties and structures important for applicability and optimize the composition. Du…