Katarina Kouter
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View article: Epigenetic and Transcriptomic Alterations of Protein Aggregation-Linked Genes in Suicide: A Pilot Study
Epigenetic and Transcriptomic Alterations of Protein Aggregation-Linked Genes in Suicide: A Pilot Study Open
Background/Objectives: Suicide is a significant public health concern with a multifactorial etiology. The biological background of suicide is not sufficiently explored, which encumbers suicide prevention. Epigenetic mechanisms may mediate …
View article: BDNF Val66Met Genotype, DNA Methylation, mRNA, and Protein Levels as Potential Blood-Based Biomarkers for Dementia and Cognitive Decline
BDNF Val66Met Genotype, DNA Methylation, mRNA, and Protein Levels as Potential Blood-Based Biomarkers for Dementia and Cognitive Decline Open
Brain-derived neurotrophic factor (BDNF) plays a crucial role in cognitive functions and dementia. In individuals with mild cognitive impairment (MCI) and dementia, we have investigated BDNF Val66Met genotype distribution, peripheral BDNF …
View article: Epigenetics and immunology: Under-recognized aspects of suicidality
Epigenetics and immunology: Under-recognized aspects of suicidality Open
Suicidality is a complex phenomenon influenced by genetic, environmental, and epigenetic factors. Current tools to estimate suicide risk are insufficient, and there is an increasing need for reliable biomarkers to complement clinical appro…
View article: Complement Cascades and Brain Disorders
Complement Cascades and Brain Disorders Open
The complement system is a vital component of innate immunity. Besides its roles in pathogen defense, its significance in neurodevelopment, neurodegeneration, and cancer progression is beginning to be recognized. We performed a comprehensi…
View article: Genotype characteristics of Y-chromosome in the Balkan population: review of haplogroup frequencies
Genotype characteristics of Y-chromosome in the Balkan population: review of haplogroup frequencies Open
The genetic structure of the Balkan peoples is complex and is reflection of continuous migration processes and settlement of various tribes and ethnic groups throughout past centuries. The human uniparental genetic markers, the Y-chromosom…
View article: Extracellular vesicles from cerebrospinal fluid revealed changes in <scp>miR</scp>‐19a‐3p and <scp>miR</scp>‐4516 expression in Slovene male suicides
Extracellular vesicles from cerebrospinal fluid revealed changes in <span>miR</span>‐19a‐3p and <span>miR</span>‐4516 expression in Slovene male suicides Open
Suicide is an important public‐health concern, with more than 700,000 people dying by suicide yearly. It is a multifactorial phenomenon, shaped by the effects of sociodemographic, environmental and biological factors. The latter two factor…
View article: DNA Methylation Patterns in Relation to Acute Severity and Duration of Anxiety and Depression
DNA Methylation Patterns in Relation to Acute Severity and Duration of Anxiety and Depression Open
Depression and anxiety are common mental disorders that often occur together. Stress is an important risk factor for both disorders, affecting pathophysiological processes through epigenetic changes that mediate gene–environment interactio…
View article: Epigenetics in psychiatry: Beyond DNA methylation
Epigenetics in psychiatry: Beyond DNA methylation Open
The global burden of psychopathologies appears to be underestimated, since the global psychiatric disorder burden is exceeding other medical burdens. To be able to address this problem more effectively, we need to better understand the eti…
View article: Effects of Mindfulness-Based Therapy on Clinical Symptoms and DNA Methylation in Patients with Polycystic Ovary Syndrome and High Metabolic Risk
Effects of Mindfulness-Based Therapy on Clinical Symptoms and DNA Methylation in Patients with Polycystic Ovary Syndrome and High Metabolic Risk Open
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder affecting women of reproductive age. Research has shown that epigenetic alterations such as DNA methylation may play a role in the development and progression of abnor…
View article: Difference in Methylation and Expression of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Mild Cognitive Impairment
Difference in Methylation and Expression of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Mild Cognitive Impairment Open
Due to the increasing number of progressive dementias in the population, numerous studies are being conducted that seek to determine risk factors, biomarkers and pathological mechanisms that could help to differentiate between normal sympt…
View article: Depressive disorder and antidepressants from an epigenetic point of view
Depressive disorder and antidepressants from an epigenetic point of view Open
Depressive disorder is a complex, heterogeneous disease that affects approximately 280 million people worldwide. Environmental, genetic, and neurobiological factors contribute to the depressive state. Since the nervous system is susceptibl…
View article: Suicide and Changes in Expression of Neuronal miRNA Predicted by an Algorithm Search through miRNA Databases
Suicide and Changes in Expression of Neuronal miRNA Predicted by an Algorithm Search through miRNA Databases Open
Suicide is multifactorial and polygenic phenotype, affected by environmental and genetic factors. Among epigenetic mechanisms, miRNAs have been studied, but so far no very concise results exist. To overcome limitations of candidate miRNA a…
View article: Targeted sequencing approach: Comprehensive analysis of DNA methylation and gene expression across blood and brain regions in suicide victims
Targeted sequencing approach: Comprehensive analysis of DNA methylation and gene expression across blood and brain regions in suicide victims Open
Results provide an insight into the altered state of DNA methylation in suicidal behaviour. Epigenetic differences could therefore affect suicidal behaviour in both previously known and in novel neuropsychiatric candidate genes.
View article: Dynamic Intercell Communication between Glioblastoma and Microenvironment through Extracellular Vesicles
Dynamic Intercell Communication between Glioblastoma and Microenvironment through Extracellular Vesicles Open
Glioblastoma is simultaneously the most common and most aggressive primary brain tumor in the central nervous system, with poor patient survival and scarce treatment options. Most primary glioblastomas reoccur and evolve radio- and chemore…
View article: <i>BDNF</i> methylation and mRNA expression in brain and blood of completed suicides in Slovenia
<i>BDNF</i> methylation and mRNA expression in brain and blood of completed suicides in Slovenia Open
Despite the limitations of the study, the obtained data further support a role for BDNF in suicidality. However, it should be noted that suicidal behavior is a multifactorial disorder with numerous environmental and genetic risk factors in…
View article: ‘Omics’ of suicidal behaviour: A path to personalised psychiatry
‘Omics’ of suicidal behaviour: A path to personalised psychiatry Open
Psychiatric disorders, including suicide, are complex disorders that are affected by many different risk factors. It has been estimated that genetic factors contribute up to 50% to suicide risk. As the candidate gene approach has not ident…
View article: Sequencing of Nucleic Acids: from the First Human Genome to Next Generation Sequencing in COVID-19 Pandemic
Sequencing of Nucleic Acids: from the First Human Genome to Next Generation Sequencing in COVID-19 Pandemic Open
Despite being around for more than 40 years, DNA sequencing is regarded as young technology in clinical medicine. As sequencing is becoming cheaper, faster and more accurate, it is rapidly being incorporated into clinical laboratories. In …
View article: Epigenetics of Alzheimer’s Disease
Epigenetics of Alzheimer’s Disease Open
There are currently no validated biomarkers which can be used to accurately diagnose Alzheimer’s disease (AD) or to distinguish it from other dementia-causing neuropathologies. Moreover, to date, only symptomatic treatments exist for this …
View article: Machine learning as the new approach in understanding biomarkers of suicidal behavior
Machine learning as the new approach in understanding biomarkers of suicidal behavior Open
In psychiatry, compared to other medical fields, the identification of biological markers that would complement current clinical interview, and enable more objective and faster clinical diagnosis, implement accurate monitoring of treatment…
View article: Biomarkers for Suicidal Behavior: miRNAs and their Potential for Diagnostics through Liquid Biopsy – a Systematic Review
Biomarkers for Suicidal Behavior: miRNAs and their Potential for Diagnostics through Liquid Biopsy – a Systematic Review Open
Background: Given that approximately 70% of miRNAs in the body are neuronal, we critically assessed current studies on miRNAs and suicidal behavior. Materials & Methods: To further define the role of miRNAs in suicide, we searched for stud…
View article: GENOME-WIDE DNA METHYLATION PATTERNS IN SUICIDE VICTIMS: IDENTIFICATION OF NEW CANDIDATE GENES
GENOME-WIDE DNA METHYLATION PATTERNS IN SUICIDE VICTIMS: IDENTIFICATION OF NEW CANDIDATE GENES Open
Suicide is a major global public health problem with significant impact on society. According to the World Health Organization, every year about 800.000 people commit suicide, while at the global level suicide accounts for 50% of all viole…