Katarina M. Guzman
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View article: Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase
Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase Open
Fragment antigen-binding domains of antibodies (Fabs) are powerful probes of structure-function relationships of assembly line polyketide synthases (PKSs). We report the discovery and characterization of Fabs interrog…
View article: Fragment antigen binding domains (Fabs) as tools to study assembly-line polyketide synthases
Fragment antigen binding domains (Fabs) as tools to study assembly-line polyketide synthases Open
The crystallization of proteins remains a bottleneck in our fundamental understanding of their functions. Therefore, discovering tools that aid crystallization is crucial. In this review, the versatility of fragment-antigen binding domains…
View article: Properties of a “Split-and-Stuttering” Module of an Assembly Line Polyketide Synthase
Properties of a “Split-and-Stuttering” Module of an Assembly Line Polyketide Synthase Open
Notwithstanding the "one-module-one-elongation-cycle" paradigm of assembly line polyketide synthases (PKSs), some PKSs harbor modules that iteratively elongate their substrates through a defined number of cycles. While some insights into m…
View article: Analysis of a “Split-and-Stuttering” Module of an Assembly Line Polyketide Synthase
Analysis of a “Split-and-Stuttering” Module of an Assembly Line Polyketide Synthase Open
Notwithstanding the “one-module-one-elongation-cycle” paradigm of assembly line polyketide synthases (PKSs), some PKSs harbor modules that iteratively elongate their substrates through a defined number of cycles. While some insights into m…