Katarína Rejleková
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View article: Humoral immune response following the third dose of BNT162b2 received by employees at a Slovak cancer healthcare facility
Humoral immune response following the third dose of BNT162b2 received by employees at a Slovak cancer healthcare facility Open
BNT162b2 is a mRNA vaccine, approved by the US Food and Drug Administration and the European Medicines Agency that was designed to target Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus dise…
View article: Representation of geriatric oncology in cancer care guidelines in Europe: a scoping review by the International Society of Geriatric Oncology (SIOG)
Representation of geriatric oncology in cancer care guidelines in Europe: a scoping review by the International Society of Geriatric Oncology (SIOG) Open
There is limited representation of geriatric oncology across European cancer guidelines. To enhance representative guideline development, there is a call for greater consideration of older adults' unique needs. Suggestions include further …
View article: Prognostic Value of Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) Score in Patients with Metastatic Renal Cell Carcinoma Treated with Nivolumab
Prognostic Value of Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) Score in Patients with Metastatic Renal Cell Carcinoma Treated with Nivolumab Open
Background: Immunotherapy based on checkpoint inhibition is widely used in the treatment of metastatic renal cell carcinoma (RCC); however, predictive and prognostic biomarkers are yet to be explored. The objective of this study was to eva…
View article: Cisplatin-induced Peripheral Neuropathy and Biomarkers of Gut Microbial Translocation in Testicular Germ Cell Tumor Survivors
Cisplatin-induced Peripheral Neuropathy and Biomarkers of Gut Microbial Translocation in Testicular Germ Cell Tumor Survivors Open
View article: Factors Associated with Humoral Immune Response Following the Third Dose of the BNT162b2 Received by Employees at a Health–Care Facility
Factors Associated with Humoral Immune Response Following the Third Dose of the BNT162b2 Received by Employees at a Health–Care Facility Open
Background: BNT162b2 represents the authorized mRNA vaccine against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS–CoV–2) causing Covid–19. Methods: We conducted a prospective, single–center observational study with 273 employees of…
View article: Prognostic role of plasma vitamin D and its association with disease characteristics in germ cell tumours
Prognostic role of plasma vitamin D and its association with disease characteristics in germ cell tumours Open
Background Testicular cancer is the most common malignancy among young men. Vitamin D has pluripotent effects on cancer pathogenesis and plays a role in the metastatic cascade. The aim of this study is to analyze plasma vitamin D in associ…
View article: Cognitive impairment and biomarkers of gut microbial translocation in testicular germ cell tumor survivors
Cognitive impairment and biomarkers of gut microbial translocation in testicular germ cell tumor survivors Open
Background Survivors of testicular germ cell tumors (GCT) may suffer from late cognitive impairment. We hypothesized that disruption of intestinal barrier during chemotherapy and/or radiotherapy may be a contributing factor of cognitive dy…
View article: Changes in CoQ10/Lipids Ratio, Oxidative Stress, and Coenzyme Q10 during First-Line Cisplatin-Based Chemotherapy in Patients with Metastatic Urothelial Carcinoma (mUC)
Changes in CoQ10/Lipids Ratio, Oxidative Stress, and Coenzyme Q10 during First-Line Cisplatin-Based Chemotherapy in Patients with Metastatic Urothelial Carcinoma (mUC) Open
Oxidative stress plays an important role in cancer pathogenesis, and thiobarbituric acid-reactive substance level (TBARS)—a parameter of lipid peroxidation—has prognostic significance in chemotherapy-naive patients with metastatic urotheli…
View article: Effects of primary granulocyte‑colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with germ cell tumors
Effects of primary granulocyte‑colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with germ cell tumors Open
Testicular germ cell tumors (GCTs) are the most common solid malignancy in males aged 15-35 years. Febrile neutropenia (FN) is a serious complication of chemotherapy that frequently occurs in patients with GCTs. The present retrospective s…
View article: Factors Associated With Choriocarcinoma Syndrome Development in Poor-Risk Patients With Germ Cell Tumors
Factors Associated With Choriocarcinoma Syndrome Development in Poor-Risk Patients With Germ Cell Tumors Open
Background Germ cell tumors (GCTs) represent a highly curable cancer. However, a small proportion of poor-risk patients can develop choriocarcinoma syndrome (CS) connected with acute respiratory distress syndrome (ARDS) with a high mortali…
View article: Detection of Specific Immune Cell Subpopulation Changes Associated with Systemic Immune Inflammation–Index Level in Germ Cell Tumors
Detection of Specific Immune Cell Subpopulation Changes Associated with Systemic Immune Inflammation–Index Level in Germ Cell Tumors Open
The tumor microenvironment (TME) and the host inflammatory response are closely interconnected. The interplay between systemic inflammation and the local immune response may influence tumor development and progression in various types of c…
View article: Comprehensive Assessment of Selected Immune Cell Subpopulations Changes in Chemotherapy-Naïve Germ Cell Tumor Patients
Comprehensive Assessment of Selected Immune Cell Subpopulations Changes in Chemotherapy-Naïve Germ Cell Tumor Patients Open
The pattern of immune cell distribution in testicular germ cell tumors (GCT) significantly differs from the immune environment in normal testicular tissues. The present study aimed to evaluate the role of different leukocyte subpopulation …
View article: Low-molecular-weight heparin prophylaxis is not associated with decreased incidence of venous thromboembolism in testicular germ cell tumor patients receiving chemotherapy
Low-molecular-weight heparin prophylaxis is not associated with decreased incidence of venous thromboembolism in testicular germ cell tumor patients receiving chemotherapy Open
Venous thromboembolism (VTE), commonly occurring in patients with testicular germ cell tumors (GCTs), is associated with increased morbidity and mortality. Prophylactic anticoagulation has been shown to decrease the risk of VTE in patients…
View article: Paclitaxel, Ifosfamide, and Cisplatin in Patients with Poor-prognosis Disseminated Nonseminomatous Germ Cell Tumors with Unfavorable Serum Tumor Marker Decline After First Cycle of Chemotherapy. The GCT-SK-003 Phase II Trial
Paclitaxel, Ifosfamide, and Cisplatin in Patients with Poor-prognosis Disseminated Nonseminomatous Germ Cell Tumors with Unfavorable Serum Tumor Marker Decline After First Cycle of Chemotherapy. The GCT-SK-003 Phase II Trial Open
View article: Are Changes in the Percentage of Specific Leukocyte Subpopulations Associated with Endogenous DNA Damage Levels in Testicular Cancer Patients?
Are Changes in the Percentage of Specific Leukocyte Subpopulations Associated with Endogenous DNA Damage Levels in Testicular Cancer Patients? Open
Chemoresistance of germ cell tumors (GCTs) represents an intensively studied property of GCTs that is the result of a complicated multifactorial process. One of the driving factors in this process is the tumor microenvironment (TME). Inten…
View article: Survival Prediction By Baseline Systemic Immune-Inflammation Index And Its Changes During First-Line Platinum-Based Treatment In A Caucasian Population Of Patients With Metastatic Urothelial Carcinoma
Survival Prediction By Baseline Systemic Immune-Inflammation Index And Its Changes During First-Line Platinum-Based Treatment In A Caucasian Population Of Patients With Metastatic Urothelial Carcinoma Open
Background: Systemic immune-inflammation index (SII) predicts survival in patients with various malignancies. This study explores the prognostic value of SII in metastatic urothelial carcinoma (MUC) subjects. Methods: We evaluated 181 cons…
View article: Cielená liečba Xp11 translokačného renálneho karcinómu
Cielená liečba Xp11 translokačného renálneho karcinómu Open
Improved survival observed in our patient could be related to the effectivity of tyrosine-kinase inhibitors, but notm-TOR inhibitors, even though disease stabilisation was observed as a best response. Identification of new treatment target…
View article: Prognostic Value of Apoptosis-Inducing Factor (AIF) in Germ Cell Tumors
Prognostic Value of Apoptosis-Inducing Factor (AIF) in Germ Cell Tumors Open
Apoptosis is a strictly regulated process essential for preservation of tissue homeostasis. This study aimed to evaluate expression of apoptosis inducing factor (AIF) in testicular germ cell tumors (GCTs) and to correlate expression patter…
View article: Intricacies of Radiographic Assessment in Testicular Germ Cell Tumors
Intricacies of Radiographic Assessment in Testicular Germ Cell Tumors Open
Testicular germ cell tumors (GCTs) are malignancies with a unique biology, pathology, clinical appearance, and excellent outcomes. A correct radiographic assessment of GCTs is extremely important for the clinical management in several typi…
View article: The effect of primary granulocyte-colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with testicular germ cell tumors
The effect of primary granulocyte-colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with testicular germ cell tumors Open
Background: Testicular germ cell tumors (GCTs) are the most common solid malignancy in men 15-35 years old. Febrile neutropenia (FN) is a serious complication of chemotherapy, frequently occurring in GCT patients. The aim of this retrospec…
View article: Successful emergency endovascular aortic repair for intratumoral hemorrhage in extensive retroperitoneal mass of testicular origin
Successful emergency endovascular aortic repair for intratumoral hemorrhage in extensive retroperitoneal mass of testicular origin Open
View article: 786P A phase II trial of paclitaxel, ifosfamid and cisplatin in patients with poor-prognosis disseminated non-seminomatous germ cell tumors with unfavorable serum tumor marker decline after first cycle of chemotherapy
786P A phase II trial of paclitaxel, ifosfamid and cisplatin in patients with poor-prognosis disseminated non-seminomatous germ cell tumors with unfavorable serum tumor marker decline after first cycle of chemotherapy Open
View article: Long-term sexual functioning in germ-cell tumor survivors
Long-term sexual functioning in germ-cell tumor survivors Open
Background Survivors of germ-cell tumors (GCT) may suffer from long-term adverse consequences. Our study was conducted to assess a long-term sexual functioning in GCT survivors. Methods GCT survivors ( N = 170) from the National Cancer Ins…
View article: Effect of prophylactic anticoagulation on the incidence of venous thromboembolism in patients with testicular germ cell tumor.
Effect of prophylactic anticoagulation on the incidence of venous thromboembolism in patients with testicular germ cell tumor. Open
Background Testicular germ cell tumors (GCTs) are among the most common solid tumors in young males. With the availability of highly effective treatment, improving patients’ quality of life has gained more focus in recent years. Venous thr…
View article: The effect of primary granulocyte-colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with testicular germ cell tumors
The effect of primary granulocyte-colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with testicular germ cell tumors Open
Background: Testicular germ cell tumors (GCTs) are the most common solid malignancy in men 15-35 years old. Febrile neutropenia (FN) is a grievous complication of chemotherapy, frequently occurring in GCT patients. The aim of this retrospe…
View article: Effect of prophylactic anticoagulation on incidence of venous thromboembolism in testicular germ cell tumor patients
Effect of prophylactic anticoagulation on incidence of venous thromboembolism in testicular germ cell tumor patients Open
Background Testicular germ cell tumors (GCTs) are among the most common solid tumors in young males. With the availability of highly effective treatment, improving patients’ quality of life has gained more focus in recent years. Venous thr…
View article: Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours
Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours Open
View article: Intraoperative tumor lysis syndrome in a giant teratoma: a case report
Intraoperative tumor lysis syndrome in a giant teratoma: a case report Open
View article: Leptomeningeal Metastasis in a Breast Cancer Treated with Two Lines of Intrathecal Chemotherapy – a Case Report
Leptomeningeal Metastasis in a Breast Cancer Treated with Two Lines of Intrathecal Chemotherapy – a Case Report Open
The prognosis of patients with LM remains poor because of the limited effectiveness of currently available therapies; however, intrathecal chemotherapy could substantially prolong survival in selected patients.
View article: Severe Complications in Testicular Germ Cell Tumors: The Choriocarcinoma Syndrome
Severe Complications in Testicular Germ Cell Tumors: The Choriocarcinoma Syndrome Open
Testicular germ cell tumors (TGCTs) represent the most common solid tumor in young men and is a model of curable cancer. The effectiveness of cisplatin-based chemotherapy secures more than 95% of patients' 5-years survival rate. However, s…