Katayi Mwila-Kazimbaya
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View article: A study protocol for a multi-arm, parallel group randomized-controlled trial evaluating the individual and combined effects of behavioural promotion and hardware provision on handwashing with soap in peri-urban Lusaka, Zambia
A study protocol for a multi-arm, parallel group randomized-controlled trial evaluating the individual and combined effects of behavioural promotion and hardware provision on handwashing with soap in peri-urban Lusaka, Zambia Open
Introduction Diarrhoea and lower respiratory infections remain leading causes of under-five mortality in sub-Saharan Africa. Handwashing with soap (HWWS) is a cost-effective intervention, yet adherence remains low. Effective interventions …
View article: How much are households willing to invest in hand hygiene enabling technologies? A randomised pricing experiment in Lusaka, Zambia
How much are households willing to invest in hand hygiene enabling technologies? A randomised pricing experiment in Lusaka, Zambia Open
Access to a dedicated handwashing facility (HWF) increases the likelihood of HWWS, an effective behaviour in preventing respiratory and diarrheal disease. The cost of a typical bucket with spigot HWF averages US$ 17 worldwide, with househo…
View article: Understanding end-user preferences for hand hygiene enabling technologies: A mixed-methods study in peri-urban Lusaka, Zambia
Understanding end-user preferences for hand hygiene enabling technologies: A mixed-methods study in peri-urban Lusaka, Zambia Open
Handwashing facilities (HWFs) are associated with higher rates of handwashing with soap, and the presence of a HWF is the global proxy indicator of household handwashing behaviour. There is limited information on HWF attributes important t…
View article: Association of biomarkers of enteric dysfunction, systemic inflammation, and growth hormone resistance with seroconversion to oral rotavirus vaccine: A lasso for inference approach
Association of biomarkers of enteric dysfunction, systemic inflammation, and growth hormone resistance with seroconversion to oral rotavirus vaccine: A lasso for inference approach Open
Background Rotavirus gastroenteritis remains a leading cause of morbidity and mortality despite the introduction of vaccines. Research shows there are several factors contributing to the reduced efficacy of rotavirus vaccines in low- and m…
View article: Shigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study
Shigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study Open
Introduction Shigellosis, is a leading cause of moderate-to-severe diarrhoea and related mortality in young children in low and middle income countries (LMICs). Knowledge on naturally acquired immunity can support the development of Shigel…
View article: Immunogenicity and safety of two monovalent rotavirus vaccines, ROTAVAC® and ROTAVAC 5D® in Zambian infants
Immunogenicity and safety of two monovalent rotavirus vaccines, ROTAVAC® and ROTAVAC 5D® in Zambian infants Open
View article: In-vitro inhibitory effect of maternal breastmilk components on rotavirus vaccine replication and association with infant seroconversion to live oral rotavirus vaccine
In-vitro inhibitory effect of maternal breastmilk components on rotavirus vaccine replication and association with infant seroconversion to live oral rotavirus vaccine Open
Background Despite contributing to a significant reduction in rotavirus associated diarrhoea in highly burdened low- and middle-income countries, live attenuated, oral rotavirus vaccines have lower immunogenicity and efficacy in these sett…
View article: Immunogenicity of rotavirus vaccine (RotarixTM) in infants with environmental enteric dysfunction
Immunogenicity of rotavirus vaccine (RotarixTM) in infants with environmental enteric dysfunction Open
Deployment of rotavirus vaccines has contributed to significant declines in diarrheal morbidity and mortality globally. Unfortunately, vaccine performance in low-middle income countries (LMICs) is generally lower than in developed countrie…
View article: Association of Maternal Immunity with Rotavirus Vaccine Immunogenicity in Zambian Infants
Association of Maternal Immunity with Rotavirus Vaccine Immunogenicity in Zambian Infants Open
IntroductionLive attenuated oral vaccines against rotavirus (RV) have been shown to be less efficacious in children from developing countries. Reasons for this disparity are not fully understood. We assessed the role of maternal factors in…
View article: Effect of innate antiviral glycoproteins in breast milk on seroconversion to rotavirus vaccine (Rotarix) in children in Lusaka, Zambia
Effect of innate antiviral glycoproteins in breast milk on seroconversion to rotavirus vaccine (Rotarix) in children in Lusaka, Zambia Open
Rotavirus vaccines have been introduced into national immunization programmes to mitigate morbidity and mortality associated rotavirus diarrhoea. Lower vaccine effectiveness has however been noted in low-middle income countries, but little…
View article: Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries
Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries Open
The role of maternal immunity, received by infants either transplacentally or orally from breast milk, in rotavirus vaccine (RV) performance is evaluated here. Breastfeeding withholding has no effect on vaccine responses, but higher levels…
View article: Early linear growth retardation: results of a prospective study of Zambian infants
Early linear growth retardation: results of a prospective study of Zambian infants Open
View article: Enterotoxigenic Escherichia Coli Toxins and Colonization Factors Among Zambian Children Presenting with Moderate to Severe Diarrhea to Selected Health Facilities
Enterotoxigenic Escherichia Coli Toxins and Colonization Factors Among Zambian Children Presenting with Moderate to Severe Diarrhea to Selected Health Facilities Open
Enterotoxigenic Escherichia Coli (ETEC) is an important cause for diarrheal disease in children and travelers globally. Epidemiological data on the distribution of strains of ETEC and associated colonization factors (CFs) is important for …
View article: Shigella and Salmonella Infections are Associated with Markers of Environmental Enteropathy among Children under Five in Zambia
Shigella and Salmonella Infections are Associated with Markers of Environmental Enteropathy among Children under Five in Zambia Open
Background: Environmental Enteropathy (EE) is a complex syndrome involving intestinal disorder which has been observed among children living in resource-poor settings. We investigated stored stool samples collected from children under-5 fo…
View article: Efficacy and Effectiveness of Rotavirus Vaccine on Incidence of Diarrhoea among Children: A Meta-analysis
Efficacy and Effectiveness of Rotavirus Vaccine on Incidence of Diarrhoea among Children: A Meta-analysis Open
Background: Introduction of rotavirus vaccines has resulted in a decrease in rotavirus related mortality and morbidity. We sought to conduct a meta-analysis to estimate the effect of rotavirus vaccine on incidence of diarrhoea. Methods: Th…
View article: vAetiology of Diarrhoea in Children Under Five in Zambia Detected Using Luminex xTAG Gastrointestinal Pathogen Panel
vAetiology of Diarrhoea in Children Under Five in Zambia Detected Using Luminex xTAG Gastrointestinal Pathogen Panel Open
Background: We aimed to document viral, bacterial, and protozoan enteric pathogens responsible of causing moderate-to-severe diarrhoea among children under five presenting at public health facilities in Zambia following the introduction of…
View article: Effect of innate antiviral glycoproteins in breast milk on seroconversion to rotavirus vaccine (Rotarix) in children in Lusaka, Zambia
Effect of innate antiviral glycoproteins in breast milk on seroconversion to rotavirus vaccine (Rotarix) in children in Lusaka, Zambia Open
High breast milk concentrations of lactadherin might play a role in infant's failure to seroconvert to rotavirus vaccines. Further research to understand this observed association is an important consideration.
View article: Immunogenicity of rotavirus vaccine (RotarixTM) in infants with environmental enteric dysfunction
Immunogenicity of rotavirus vaccine (RotarixTM) in infants with environmental enteric dysfunction Open
We found that high levels of zonulin and IFABP played a role in seroconversion. It is plausible that increased gut permeability in EED allows greater uptake of the live virus within the vaccine, but later consequences result in deleterious…
View article: Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries
Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries Open
The role of maternal immunity, received by infants either transplacentally or orally from breast milk, in rotavirus vaccine (RV) performance is evaluated here. Breastfeeding withholding has no effect on vaccine responses, but higher levels…
View article: Association of Maternal Immunity with Rotavirus Vaccine Immunogenicity in Zambian Infants
Association of Maternal Immunity with Rotavirus Vaccine Immunogenicity in Zambian Infants Open
Low immunogenicity of RV1 vaccine could be explained in part by exposure to high antibody titres in breast milk and early exposure to wild-type rotavirus infections. Potential interference of anti-RV specific IgA in breast milk and pre-vac…