Katayoun Derakhshandeh
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View article: Preparation and characterization of tadalafil-loaded hydrogel: An in-vivo evaluation of wound healing activity
Preparation and characterization of tadalafil-loaded hydrogel: An in-vivo evaluation of wound healing activity Open
Tadalafil (TD) is a phosphodiesterase type 5 (PDE-5) inhibitor that has gained attention for its wound healing properties. In this study, a TD-loaded hydrogel was prepared and characterized, and its wound-healing efficacy was evaluated. Af…
View article: Prognostic markers and molecular pathways in primary colorectal cancer with a high potential of liver metastases: a systems biology approach
Prognostic markers and molecular pathways in primary colorectal cancer with a high potential of liver metastases: a systems biology approach Open
Background and purpose: Colorectal cancer (CRC) holds the position of being the third most prevalent cancer and the second primary cause of cancer-related fatalities on a global scale. Approximately 65% of CRC patients survive for 5 years …
View article: CCDC 2223417: Experimental Crystal Structure Determination
CCDC 2223417: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2219077: Experimental Crystal Structure Determination
CCDC 2219077: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Wheat germ agglutinin conjugated chitosan nanoparticles for gemcitabine delivery in MCF-7 cells; synthesis, characterisation and in vitro cytotoxicity studies
Wheat germ agglutinin conjugated chitosan nanoparticles for gemcitabine delivery in MCF-7 cells; synthesis, characterisation and in vitro cytotoxicity studies Open
Objective and Aim: Numerous clinical trials indicated combination regimens containing gemcitabine could extend progression-free survival of breast cancer patients without increasing the incidence of serious adverse effects. Orally administ…
View article: Development of a Label-Free, Sensitive Gold Nanoparticles-Poly (Adenine)Aptasensing Platform for Colorimetric Determination of Aflatoxin B1 in Corn
Development of a Label-Free, Sensitive Gold Nanoparticles-Poly (Adenine)Aptasensing Platform for Colorimetric Determination of Aflatoxin B1 in Corn Open
View article: In vitro anticancer activities, multi-spectroscopic and in silico DNA binding studies of propranolol drug and its new Zn(II) complex
In vitro anticancer activities, multi-spectroscopic and in silico DNA binding studies of propranolol drug and its new Zn(II) complex Open
A new Zn(II) complex of propranolol (PPN), [Zn2(PPN)2(μ-Cl)2] (ZnPPN), was synthesized and characterized using 1H NMR and FT-IR spectroscopies, CHN elemental analysis, cyclic voltammetry (CV) and conductance measurements. Then the interact…
View article: Clofibrate in the Treatment of the Non-hemolytic Hyperbilirubinemia in Preterm Neonates in Western Iran
Clofibrate in the Treatment of the Non-hemolytic Hyperbilirubinemia in Preterm Neonates in Western Iran Open
Background: No studies, to the best of our knowledge, have been conducted on the effect of Clofibrate in reducing hyperbilirubinemia in preterm infants. Therefore, this study aimed at investigating the therapeutic effect of Clofibrate in t…
View article: Enhancement of in vitro antitumour activity of epirubicin in HER2+ breast cancer cells using immunoliposome formulation
Enhancement of in vitro antitumour activity of epirubicin in HER2+ breast cancer cells using immunoliposome formulation Open
Epirubicin (EPI) is one of the potent breast cancer (BC) chemotherapeutic agents, but its adverse effects limit its efficacy. Herein, EPI was selected to be loaded in liposomal carrier, which has been targeted by a monoclonal antibody, Her…
View article: Targeting Solid Lipid Nanoparticles with Anisamide for Docetaxel Delivery to Prostate Cancer: Preparation, Optimization, and <i>In-vitro</i> Evaluation.
Targeting Solid Lipid Nanoparticles with Anisamide for Docetaxel Delivery to Prostate Cancer: Preparation, Optimization, and <i>In-vitro</i> Evaluation. Open
The purpose of the current study was to prepare and characterize the targeted solid lipid nanoparticles (SLNs) containing docetaxel (DTX) for prostate cancer treatment. The goal has been achieved by locating anisamide (Anis) ligand on the …
View article: Therapeutic Drug Monitoring of Vancomycin: The Relationship Between Trough Plasma Concentration and Creatinine Clearance
Therapeutic Drug Monitoring of Vancomycin: The Relationship Between Trough Plasma Concentration and Creatinine Clearance Open
Background: In this study which was conducted in Besat hospital (Hamadan, Iran), the therapeutic drug monitoring (TDM) of vancomycin (VAN) was carried out based on the quantification of VAN trough in intensive care unit (ICU) patients. Met…
View article: Oral delivery of indinavir using mPEG-PCL nanoparticles: preparation, optimization, cellular uptake, transport and pharmacokinetic evaluation
Oral delivery of indinavir using mPEG-PCL nanoparticles: preparation, optimization, cellular uptake, transport and pharmacokinetic evaluation Open
Introduction Indinavir (IDV) is a potent HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV). IDV is a weak base with limited aqueous solubility in its unprotonated form; therefore, solubility of IDV in the g…
View article: β-lactoglobulin-irinotecan inclusion complex as a new targeted nanocarrier for colorectal cancer cells
β-lactoglobulin-irinotecan inclusion complex as a new targeted nanocarrier for colorectal cancer cells Open
Beta-lactoglobulin (β-LG) is a lipocalin family member whose general function appears to be solubilizing and transport of hydrophobic molecules. Some properties such as avalability, ease of purification, and peculiar resistance to acidic e…
View article: Preparation and physicochemical evaluation of topical formulations of purified curcuminoids from Curcuma longa rhizome
Preparation and physicochemical evaluation of topical formulations of purified curcuminoids from Curcuma longa rhizome Open
Background and objectives: The purpose of this study was optimization of semisolid topical formulation from ethanol extract of turmeric and evaluation of rheological characterization and investigation of physicochemical control tests. Meth…
View article: Adhesion Prevention by Peritoneal Administration of Herbal Hydrogel
Adhesion Prevention by Peritoneal Administration of Herbal Hydrogel Open
Introduction Abdominal adhesions are abnormal bands of tissues between structures and organs in abdomen following injury to the peritoneal surface. The most common cause of intra-abdominal adhesions estimated as high as 80%, is a history o…
View article: Pharmacokinetic study of furosemide incorporated PLGA microspheres after oral administration to rat.
Pharmacokinetic study of furosemide incorporated PLGA microspheres after oral administration to rat. Open
The results showed that the prepared microspheres successfully improved BA of the poorly water-soluble drug effectively.
View article: Active-targeted Nanotherapy as Smart Cancer Treatment
Active-targeted Nanotherapy as Smart Cancer Treatment Open
Drug delivery systems (DDS) can be designed to improve the pharmacological and therapeutic properties of drugs. Targeted drug delivery, sometimes called smart drug delivery, is a method of delivering medication to a patient in a manner tha…
View article: Safety and efficacy of Intraurethral Mitomycin C Hydrogel for prevention of post-traumatic anterior Urethral stricture recurrence after internal urethrotomy
Safety and efficacy of Intraurethral Mitomycin C Hydrogel for prevention of post-traumatic anterior Urethral stricture recurrence after internal urethrotomy Open
Based on our results, MMC Hydrogel may have an anti-fibrotic action preventing post-traumatic anterior urethral stricture recurrence with no side effects on pre-urethral tissue. Due to our study limitations, our follow up time and the smal…
View article: The Role of Nanoparticle in Brain Permeability: An in-vitro BBB Model.
The Role of Nanoparticle in Brain Permeability: An in-vitro BBB Model. Open
Membrane permeability and P-glycoprotein (P-gp) efflux system are regulating factors in the drug brain penetration. Recently, some drug delivery systems have been developed to overcome these limitations. In this study, Metoclopramid has be…
View article: Active targeted nanoparticles: Preparation, physicochemical characterization and in vitro cytotoxicity effect.
Active targeted nanoparticles: Preparation, physicochemical characterization and in vitro cytotoxicity effect. Open
In this study, the folate decorated biodegradable poly (lactide-co-glycolide) (PLGA) nanoparticles were developed for tumor targeting of anticancer agents. Due to the overexpression of the folate receptor on tumor surface, the folate has b…
View article: Encapsulation in PLGA-PEG enhances 9- nitro-camptothecin cytotoxicity to human ovarian carcinoma cell line through apoptosis pathway.
Encapsulation in PLGA-PEG enhances 9- nitro-camptothecin cytotoxicity to human ovarian carcinoma cell line through apoptosis pathway. Open
Ovarian cancer is the fifth leading cause of the cancer-related death among women. 9-nitrocamptothecin (9-NC) is a water-insoluble derivative of camptothecin used for the treatment of patients with advanced ovarian cancer. Previous studies…
View article: Effects of Levothyroxine Treatment on Lipid Profile in Subclinical Hypothyroidism: A Randomized Clinical Trial
Effects of Levothyroxine Treatment on Lipid Profile in Subclinical Hypothyroidism: A Randomized Clinical Trial Open
Background: Studies demonstrated controversial results on subclinical hypothyroidism (SCH) regarding lipid profile alteration with or without Levothyroxine treatment. The purpose of this study is to investigate the effects of Levothyroxine…
View article: Development and optimization of buspirone oral osmotic pump tablet.
Development and optimization of buspirone oral osmotic pump tablet. Open
The aim of the current study was to design a porous osmotic pump-based drug delivery system for controlling the release of buspirone from the delivery system. The osmotic pump was successfully developed using symmetric membrane coating. Th…
View article: Clinical Features and Drug Characteristics of Patients with Generalized Fixed Drug Eruption in the West of Iran (2005–2014)
Clinical Features and Drug Characteristics of Patients with Generalized Fixed Drug Eruption in the West of Iran (2005–2014) Open
Background. Generalized fixed drug eruption is a specific variant of fixed drug eruption with multifocal lesions. Diagnosis of this drug reaction is straightforward, but occasionally recognition of the causative drug is not possible. This …