Kate E. Killick
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View article: Integrative and comparative genomic analyses of mammalian macrophage responses to intracellular mycobacterial pathogens
Integrative and comparative genomic analyses of mammalian macrophage responses to intracellular mycobacterial pathogens Open
Mycobacterium tuberculosis , the causative agent of human tuberculosis (hTB), is currently classed as the thirteenth leading cause of death worldwide. Mycobacterium bovis , a close evolutionary relative of M. tuberculosis , causes bovine t…
View article: Additional file 3 of Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria
Additional file 3 of Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria Open
Additional file 3. Outputs from correlation network analyses using DGCA with MEGENA and CON-24 and CON-48 input gene sets for GWAS integration.
View article: Additional file 1 of Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria
Additional file 1 of Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria Open
Additional file 1. Differentially expressed genes across the infection time course and DEG-24 and DEG-48 input gene sets for GWAS integration.
View article: Additional file 6 of Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria
Additional file 6 of Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria Open
Additional file 6. Functional genomics and GWAS integration results for Charolais (CHA), Limousin (LIM) and Holstein-Friesian (HOF).
View article: Additional file 2 of Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria
Additional file 2 of Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria Open
Additional file 2. Enriched IPA canonical pathways at 24 and 48 hpi.
View article: Additional file 5 of Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria
Additional file 5 of Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria Open
Additional file 5. 100 random (RAN) input gene sets used for GWAS integration.
View article: Additional file 4 of Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria
Additional file 4 of Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria Open
Additional file 4. Outputs from differential network analyses using GeneCards®, InnateDB with Cytoscape/jActiveModules and DEN-24 and DEN-48 input gene sets for GWAS integration.
View article: Additional file 7 of Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria
Additional file 7 of Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria Open
Additional file 7. GWAS prioritised SNP results for Charolais (CHA), Limousin (LIM) and Holstein-Friesian (HOF).
View article: Integrative Genomics of the Mammalian Alveolar Macrophage Response to Intracellular Mycobacteria
Integrative Genomics of the Mammalian Alveolar Macrophage Response to Intracellular Mycobacteria Open
BackgroundBovine TB (BTB), caused by infection with Mycobacterium bovis, is a major endemic disease affecting global cattle production, particularly in many developing countries. The key innate immune that first encounters the pathogen is …
View article: Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria
Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria Open
Bovine tuberculosis (bTB), caused by infection with Mycobacterium bovis , is a major disease affecting cattle globally as well as being a zoonotic risk to human health. The key innate immune cell that first encounters M. bovis is the alveo…
View article: KH-type splicing regulatory protein controls colorectal cancer cell growth and modulates the tumor microenvironment
KH-type splicing regulatory protein controls colorectal cancer cell growth and modulates the tumor microenvironment Open
KH-type splicing regulatory protein (KHSRP) is a multifunctional nucleic acid binding protein implicated in key aspects of cancer cell biology: inflammation and cell-fate determination. However, the role KHSRP plays in colorectal cancer (C…
View article: Network Analysis of the Systemic Response to Fasciola hepatica Infection in Sheep Reveals Changes in Fibrosis, Apoptosis, Toll-Like Receptors 3/4, and B Cell Function
Network Analysis of the Systemic Response to Fasciola hepatica Infection in Sheep Reveals Changes in Fibrosis, Apoptosis, Toll-Like Receptors 3/4, and B Cell Function Open
The Trematode Fasciola hepatica is an important cause of disease in livestock and in man. Modulation of immunity is a critical strategy used by this parasite to facilitate its long-term survival in the host. Understanding the underlying me…
View article: Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma
Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma Open
Despite intensive study, many mysteries remain about the MYCN oncogene's functions. Here we focus on MYCN's role in neuroblastoma, the most common extracranial childhood cancer. MYCN gene amplification occurs in 20% of cases, but other rec…
View article: RNA sequencing provides exquisite insight into the manipulation of the alveolar macrophage by tubercle bacilli
RNA sequencing provides exquisite insight into the manipulation of the alveolar macrophage by tubercle bacilli Open
Mycobacterium bovis , the agent of bovine tuberculosis, causes an estimated $3 billion annual losses to global agriculture due, in part, to the limitations of current diagnostics. Development of next-generation diagnostics requires a great…
View article: Analysis of the Bovine Monocyte-Derived Macrophage Response to Mycobacterium avium Subspecies Paratuberculosis Infection Using RNA-seq
Analysis of the Bovine Monocyte-Derived Macrophage Response to Mycobacterium avium Subspecies Paratuberculosis Infection Using RNA-seq Open
Johne's disease, caused by infection with Mycobacterium avium subsp. paratuberculosis, (MAP), is a chronic intestinal disease of ruminants with serious economic consequences for cattle production in the United States and elsewhere. During …