Katherine J. Evans
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View article: The <i>Saccharomyces</i> killer toxin K62 is a protein of the aerolysin family
The <i>Saccharomyces</i> killer toxin K62 is a protein of the aerolysin family Open
K62 is an antifungal killer toxin produced by Saccharomyces paradoxus , encoded by a double-stranded RNA satellite. The toxin exhibits a unique antifungal activity but lacks sequence homology to other killer toxins, and its antifungal mech…
View article: Improving the Quadrupole to Ion Mobility Region in a Digital Quadrupole/Ion Mobility/Orbitrap Mass Spectrometer
Improving the Quadrupole to Ion Mobility Region in a Digital Quadrupole/Ion Mobility/Orbitrap Mass Spectrometer Open
A quadrupole/drift tube ion mobility/Orbitrap instrument requires pumping from atmosphere to 10-5 Torr in the quadrupole analyzer region, back to 1 Torr for the drift tube, and a return to 10-5 Torr for the Orbitrap high vacuum region. The…
View article: Roles of Hydration in Protein–Ligand Binding: Passive or Active Participant?
Roles of Hydration in Protein–Ligand Binding: Passive or Active Participant? Open
Hydration is a critical yet often underappreciated factor that influences protein dynamics in solution, with direct effects on structure, stability, and interactions such as ligand binding. Native mass spectrometry (nMS) enables the analys…
View article: High sensitivity of simulated fog properties to parameterized aerosol activation in case studies from ParisFog
High sensitivity of simulated fog properties to parameterized aerosol activation in case studies from ParisFog Open
Aerosols influence fog properties such as visibility and lifetime by affecting fog droplet number concentrations (Nd). Numerical weather prediction (NWP) models often represent aerosol–fog interactions using highly simplified approaches. I…
View article: Adiabatic and radiative cooling are both important causes of aerosol activation in simulated fog events in Europe
Adiabatic and radiative cooling are both important causes of aerosol activation in simulated fog events in Europe Open
Aerosol–fog interactions affect the visibility in, and life cycle of, fog and are difficult to represent in weather and climate models. Here we explore processes that impact the simulation of fog droplet number concentrations (Nd) at sub-k…
View article: Allostery without Conformational Change: A Native Mass Spectrometry Perspective
Allostery without Conformational Change: A Native Mass Spectrometry Perspective Open
Native electrospray ionization-mass spectrometry (nESI-MS) enables studies of intact proteins, protein complexes, and protein-ligand complexes. Variable temperature (vT)-nESI-MS, where the temperature of the solution contained in the ESI e…
View article: Assessing modifications to the Abdul-Razzak and Ghan aerosol activation parameterization (version ARG2000) to improve simulated aerosol–cloud radiative effects in the UK Met Office Unified Model (UM version 13.0)
Assessing modifications to the Abdul-Razzak and Ghan aerosol activation parameterization (version ARG2000) to improve simulated aerosol–cloud radiative effects in the UK Met Office Unified Model (UM version 13.0) Open
The representation of aerosol activation is a key source of uncertainty in global composition-climate model simulations of aerosol–cloud interactions. The Abdul-Razzak and Ghan (ARG) activation parameterization is used in several global an…
View article: Cell cycle dysregulation of globally important SAR11 bacteria resulting from environmental perturbation
Cell cycle dysregulation of globally important SAR11 bacteria resulting from environmental perturbation Open
Genome streamlining is hypothesized to occur in bacteria as an adaptation to resource-limited environments, but can result in gene losses affecting fundamental aspects of cellular physiology. The most abundant marine microorganisms, SAR11 …
View article: Allostery Without Conformational Change: A Native Mass Spectrometry Perspective
Allostery Without Conformational Change: A Native Mass Spectrometry Perspective Open
Native electrospray ionization mass spectrometry (nESI-MS) enables studies of intact proteins, protein complexes, and protein-protein and protein-ligand complexes. Variable temperature (vT)-nESI-MS, where the temperature of the solution co…
View article: High sensitivity of simulated fog properties to parameterized aerosol activation in case studies from ParisFog
High sensitivity of simulated fog properties to parameterized aerosol activation in case studies from ParisFog Open
Aerosols influence fog properties such as visibility and lifetime by affecting fog droplet number concentrations (Nd). Numerical weather prediction (NWP) models often represent aerosol-fog interactions using highly simplified approaches. I…
View article: Adiabatic and radiative cooling are both important causes of aerosol activation in simulated fog events in Europe
Adiabatic and radiative cooling are both important causes of aerosol activation in simulated fog events in Europe Open
Aerosol-fog interactions affect the visibility in, and life cycle of, fog and are difficult to represent in weather and climate models. Here we explore processes that impact the simulation of fog droplet number concentrations (Nd) at sub-k…
View article: Modifying the Abdul-Razzak & Ghan aerosol activation parameterization (version ARG2000) impacts simulated cloud radiative effects (shown in the UK Met Office Unified Model, version 13.0)
Modifying the Abdul-Razzak & Ghan aerosol activation parameterization (version ARG2000) impacts simulated cloud radiative effects (shown in the UK Met Office Unified Model, version 13.0) Open
The representation of aerosol activation is a key source of uncertainty in global composition-climate model simulations of aerosol-cloud interactions. The Abdul-Razzak and Ghan (ARG) activation parameterization is used in several global an…
View article: Causal effect of the infield shift in the MLB
Causal effect of the infield shift in the MLB Open
The infield shift has been increasingly used as a defensive strategy in baseball in recent years. Along with the upward trend in its usage, the notoriety of the shift has grown, as it is believed to be responsible for the recent decline in…
View article: Exploring New Zealand’s Remote Fjords
Exploring New Zealand’s Remote Fjords Open
Doing research in Fiordland—a vast territory of mountains, forests, and fiords in southwest New Zealand—takes ingenuity, collaboration, and a really good raincoat.
View article: Climate change is not the primary cause of extreme monsoons in Pakistan
Climate change is not the primary cause of extreme monsoons in Pakistan Open
Monsoons have been frequently severe in Pakistan in the last few decades, leading to extreme droughts and floods of unprecedented proportions. The wide belief is that these changing precipitation patterns are mainly due to climate change. …
View article: An implicit barotropic mode solver for MPAS-ocean using a modern Fortran solver interface
An implicit barotropic mode solver for MPAS-ocean using a modern Fortran solver interface Open
We demonstrate use of a modern Fortran solver interface to manage solver algorithms for an implicit barotropic mode solver in the Model for Predictions Across Scales-Ocean (MPAS-O). ForTrilinos, a Fortran interface to Trilinos that contain…
View article: The influence of natural variability on extreme monsoons in Pakistan
The influence of natural variability on extreme monsoons in Pakistan Open
The monsoons in Pakistan have been exceptionally harsh in recent decades, resulting in extraordinary drought conditions and record flooding events. The changing characteristics of extreme events are widely attributed to climate change. How…
View article: Automated Driving Without Ethics: Meaning, Design and Real-World Implementation
Automated Driving Without Ethics: Meaning, Design and Real-World Implementation Open
The ethics of automated vehicles (AV) has received a great amount of attention in recent years, specifically in regard to their decisional policies in accident situations in which human harm is a likely consequence. After a discussion abou…
View article: The influence of natural variability on extreme monsoons in Pakistan
The influence of natural variability on extreme monsoons in Pakistan Open
The monsoons in Pakistan have been exceptionally harsh in recent decades, resulting in extraordinary drought conditions and record flooding events. The changing frequency of extreme events is widely attributed to climate change. However, g…
View article: Semi-implicit barotropic mode solver using ForTrilinos in MPAS-O and its test data
Semi-implicit barotropic mode solver using ForTrilinos in MPAS-O and its test data Open
To run the ForTrilinos-enabled MPAS-O, Download all files Install Trilinos Unzip: tar -xzvf Trilinos.tar.gz cd Trilinos ; mkdir build ; cd build ; cp ../do-configure_gnu ./ Check install directories and options in 'do-configure_gnu' Run 'd…
View article: Semi-implicit barotropic mode solver using ForTrilinos in MPAS-O and its test data
Semi-implicit barotropic mode solver using ForTrilinos in MPAS-O and its test data Open
To run the ForTrilinos-enabled MPAS-O, Download all files Install Trilinos Unzip: tar -xzvf Trilinos.tar.gz cd Trilinos ; mkdir build ; cd build ; cp ../do-configure_gnu ./ Check install directories and options in 'do-configure_gnu' Run 'd…
View article: Role of Indian Ocean heating anomalies in the early winter ENSO teleconnection to the South Asian and North Atlantic regions
Role of Indian Ocean heating anomalies in the early winter ENSO teleconnection to the South Asian and North Atlantic regions Open
<p>The role of the Indian Ocean heating anomalies in the ENSO teleconnection to South Asia and North Atlantic/European regions are investigated in the early winter season. Using re-analysis data, CMIP5 simulations and idealized numer…