Kate Huffer
YOU?
Author Swipe
View article: Conservation of the cooling agent binding pocket within the TRPM subfamily
Conservation of the cooling agent binding pocket within the TRPM subfamily Open
Transient receptor potential (TRP) channels are a large and diverse family of tetrameric cation-selective channels that are activated by many different types of stimuli, including noxious heat or cold, organic ligands such as vanilloids or…
View article: Conservation of the cooling agent binding pocket within the TRPM subfamily
Conservation of the cooling agent binding pocket within the TRPM subfamily Open
Transient Receptor Potential (TRP) channels are a large and diverse family of tetrameric cation selective channels that are activated by many different types of stimuli, including noxious heat or cold, organic ligands such as vanilloids or…
View article: Conservation of the cooling agent binding pocket within the TRPM subfamily
Conservation of the cooling agent binding pocket within the TRPM subfamily Open
Transient receptor potential (TRP) channels are a large and diverse family of tetrameric cation-selective channels that are activated by many different types of stimuli, including noxious heat or cold, organic ligands such as vanilloids or…
View article: Conservation of the cooling agent binding pocket within the TRPM subfamily
Conservation of the cooling agent binding pocket within the TRPM subfamily Open
Transient Receptor Potential (TRP) channels are a large and diverse family of tetrameric cation selective channels that are activated by many different types of stimuli, including noxious heat or cold, organic ligands such as vanilloids or…
View article: Conservation of the cooling agent binding pocket within the TRPM subfamily
Conservation of the cooling agent binding pocket within the TRPM subfamily Open
Transient Receptor Potential (TRP) channels are a large and diverse family of tetrameric cation selective channels that are activated by many different types of stimuli, including noxious heat or cold, organic ligands such as vanilloids or…
View article: Ion permeation pathway within the internal pore of P2X receptor channels
Ion permeation pathway within the internal pore of P2X receptor channels Open
P2X receptor channels are trimeric ATP-activated ion channels expressed in neuronal and non-neuronal cells that are attractive therapeutic targets for human disorders. Seven subtypes of P2X receptor channels have been identified in mammals…
View article: Ion permeation pathway within the internal pore of P2X receptor channels
Ion permeation pathway within the internal pore of P2X receptor channels Open
P2X receptor channels are trimeric ATP-activated ion channels expressed in neuronal and non-neuronal cells that are attractive therapeutic targets for human disorders. Seven subtypes of P2X receptor channels have been identified in mammals…
View article: Structure of the Shaker Kv channel and mechanism of slow C-type inactivation
Structure of the Shaker Kv channel and mechanism of slow C-type inactivation Open
Voltage-activated potassium (Kv) channels open upon membrane depolarization and proceed to spontaneously inactivate. Inactivation controls neuronal firing rates and serves as a form of short-term memory and is implicated in various human n…
View article: Structure of the Shaker Kv channel and mechanism of slow C-type inactivation
Structure of the Shaker Kv channel and mechanism of slow C-type inactivation Open
Voltage-activated potassium (Kv) channels open upon membrane depolarization and proceed to spontaneously inactivate. Inactivation controls neuronal firing rates and serves as a form of short-term memory, and is implicated in various human …
View article: Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms
Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms Open
The recent proliferation of published TRP channel structures provides a foundation for understanding the diverse functional properties of this important family of ion channel proteins. To facilitate mechanistic investigations, we construct…
View article: Underlying data for "Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms"
Underlying data for "Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms" Open
Output Files from Structural Alignment of TRP Channels The archive contains the key output files resulting from the structural alignment of members of the TRP channel family described in "Global alignment and assessment of TRP channel tran…
View article: Underlying data for "Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms"
Underlying data for "Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms" Open
Output Files from Structural Alignment of TRP Channels The archive contains the key output files resulting from the structural alignment of members of the TRP channel family described in "Global alignment and assessment of TRP channel tran…
View article: Author response: Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms
Author response: Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The recent proliferation of published TRP …
View article: Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms
Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms Open
The recent proliferation of published TRP channel structures provides a foundation for understanding the diverse functional properties of this important family of ion channel proteins. To facilitate mechanistic investigations, we construct…
View article: The ion selectivity filter is not an activation gate in TRPV1-3 channels
The ion selectivity filter is not an activation gate in TRPV1-3 channels Open
Activation of TRPV1 channels in sensory neurons results in opening of a cation permeation pathway that triggers the sensation of pain. Opening of TRPV1 has been proposed to involve two gates that appear to prevent ion permeation in the abs…