Kate L. Ormerod
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View article: Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation
Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation Open
Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than 600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties (i.e. grubii and neoformans, respectively). Here, we sequence…
View article: Recipient mucosal-associated invariant T cells control GVHD within the colon
Recipient mucosal-associated invariant T cells control GVHD within the colon Open
Mucosal-associated invariant T (MAIT) cells are a unique innate-like T cell subset that responds to a wide array of bacteria and yeast through recognition of riboflavin metabolites presented by the MHC class I-like molecule MR1. Here, we d…
View article: Convergent microevolution of Cryptococcus neoformans hypervirulence in the laboratory and the clinic
Convergent microevolution of Cryptococcus neoformans hypervirulence in the laboratory and the clinic Open
Reference strains are a key component of laboratory research, providing a common background allowing for comparisons across a community of researchers. However, laboratory passage of these strains has been shown to lead to reduced fitness …
View article: Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome
Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome Open
Key Points Recipient-derived IL-17A is critical for the prevention of intestinal acute GVHD. Increased susceptibility to acute GVHD can be transferred to WT mice via cohousing with IL-17RA or IL-17RC–deficient mice.
View article: Additional file 6: Table S3. of Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals
Additional file 6: Table S3. of Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals Open
Cell wall associated PFAMs identified in â Ca. Homeothermaceaeâ genomes. (XLSX 13 kb)
View article: Additional file 19: Table S10. of Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals
Additional file 19: Table S10. of Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals Open
COGs with significantly altered abundance in â Ca. Homeothermaceaeâ versus related Bacteroidales families. (XLSX 57 kb)
View article: Polyploid Titan Cells Produce Haploid and Aneuploid Progeny To Promote Stress Adaptation
Polyploid Titan Cells Produce Haploid and Aneuploid Progeny To Promote Stress Adaptation Open
Cryptococcus neoformans is a major life-threatening fungal pathogen. In response to the stress of the host environment, C. neoformans produces large polyploid titan cells. Titan cell production enhances the virulence of C. neoformans , yet…
View article: Comparative genomics of non-pseudomonal bacterial species colonising paediatric cystic fibrosis patients
Comparative genomics of non-pseudomonal bacterial species colonising paediatric cystic fibrosis patients Open
The genetic disorder cystic fibrosis is a life-limiting condition affecting ∼70,000 people worldwide. Targeted, early, treatment of the dominant infecting species, Pseudomonas aeruginosa, has improved patient outcomes; however, there is co…