Kate M. Crowther
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View article: Structural determinants for GqPCR-mediated inhibition of TASK K2P K<sup>+</sup> channels and their dysfunction in disease
Structural determinants for GqPCR-mediated inhibition of TASK K2P K<sup>+</sup> channels and their dysfunction in disease Open
Two-Pore Domain K + (K2P) channels are crucial determinants of cellular electrical excitability. TASK-1 and TASK-3 K2P channels regulate the resting membrane potential in many different cell types where their activity is also coupled to Gq…
View article: Residues in the 1st Transmembrane-Spanning Helix Are Important for GABAAρ Receptor Function
Residues in the 1st Transmembrane-Spanning Helix Are Important for GABAAρ Receptor Function Open
GABAAρ receptors are a subfamily of the GABAA receptor family of pentameric ligand-gated ion channels (pLGICs). Each subunit has a common structure, including a transmembrane domain of four α-helices (M1–M4). The aim of this study was to i…