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View article: A novel simulated media system for in vitro evaluation of bioequivalent intestinal drug solubility
A novel simulated media system for in vitro evaluation of bioequivalent intestinal drug solubility Open
Orally administered solid drug must dissolve in the gastrointestinal tract before absorption to provide a systemic response. Intestinal solubility is therefore crucial but difficult to measure since human intestinal fluid (HIF) is challeng…
View article: Structured solubility behaviour in fed simulated intestinal fluids
Structured solubility behaviour in fed simulated intestinal fluids Open
Intestinal drug solubility is a key parameter controlling absorption after the administration of a solid oral dosage form. The ability to measure fed state solubility in vitro is limited and multiple simulated intestinal fluid recipes have…
View article: Supporting food effect prediction using biorelevant small scale in vitro solubility approaches
Supporting food effect prediction using biorelevant small scale in vitro solubility approaches Open
Thisstudy applies biorelevant fasted and fed simulated intestinal media (SIM) to comparethe solubility of griseofulvin, ibuprofen, and dipyridamole to investigate theprediction of food effects. These media cover over 90% of the human intes…
View article: Fed intestinal solubility limits and distributions applied to the Developability classification system
Fed intestinal solubility limits and distributions applied to the Developability classification system Open
For solid oral dosage forms drug solubility in intestinal fluid is an important parameter influencing product performance and bioavailability. Solubility along with permeability are the two parameters applied in the Biopharmaceutics and De…
View article: Anxiety Around Learning R in First Year Undergraduate Students: Mathematics versus Biomedical Sciences Students
Anxiety Around Learning R in First Year Undergraduate Students: Mathematics versus Biomedical Sciences Students Open
R is becoming the standard for teaching statistics due to its flexibility, and open-source nature, replacing software programs like Minitab and SPSS. The main driver for reform within Scottish statistical undergraduate programs is the crea…
View article: Structured Solubility Behaviour in Fed Simulated Intestinal Fluids
Structured Solubility Behaviour in Fed Simulated Intestinal Fluids Open
View article: Short-term and long-term impacts of COVID-19 on economic vulnerability: a population-based longitudinal study (COVIDENCE UK)
Short-term and long-term impacts of COVID-19 on economic vulnerability: a population-based longitudinal study (COVIDENCE UK) Open
Objective To determine whether COVID-19 has a significant impact on adequacy of household income to meet basic needs (primary outcome) and work absence due to sickness (secondary outcome), both at the onset of illness (short term) and subs…
View article: Effects of cocaine and heroin, and their combination, on the development rate of Calliphora vomitoria (Diptera: Calliphoridae)
Effects of cocaine and heroin, and their combination, on the development rate of Calliphora vomitoria (Diptera: Calliphoridae) Open
Insects present on or near decomposing bodies are collected by forensic entomologists and used to estimate the post-mortem interval. Drugs metabolized by a person before death may affect the rate of development of insects feeding on the co…
View article: Small scale in vitro method to determine a potential bioequivalent equilibrium solubility range for fed human intestinal fluid
Small scale in vitro method to determine a potential bioequivalent equilibrium solubility range for fed human intestinal fluid Open
Intestinal drug solubility is a key parameter controlling oral absorption but varies both intra and inter individuals and between the fasted and fed states, with food intake known to alter the bioavailability of many compounds. Intestinal …
View article: Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids
Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids Open
Drug solubility in intestinal fluid is a key parameter controlling absorption after the administration of a solid oral dosage form. To measure solubility in vitro simulated intestinal fluids have been developed, but there are multiple reci…
View article: Acute and long-term impacts of COVID-19 on economic vulnerability: a population-based longitudinal study (COVIDENCE UK)
Acute and long-term impacts of COVID-19 on economic vulnerability: a population-based longitudinal study (COVIDENCE UK) Open
Background Socio-economic deprivation is well recognised as a risk factor for developing COVID-19. However, the impact of COVID-19 on economic vulnerability has not previously been characterised. Objective To determine whether COVID-19 has…
View article: Structured Solubility Behaviour in Bioequivalent Fasted Simulated Intestinal Fluids
Structured Solubility Behaviour in Bioequivalent Fasted Simulated Intestinal Fluids Open
View article: Fasted intestinal solubility limits and distributions applied to the biopharmaceutics and developability classification systems
Fasted intestinal solubility limits and distributions applied to the biopharmaceutics and developability classification systems Open
View article: Small scale in vitro method to determine a bioequivalent equilibrium solubility range for fasted human intestinal fluid
Small scale in vitro method to determine a bioequivalent equilibrium solubility range for fasted human intestinal fluid Open
View article: Quantifying the impact of the modifiable areal unit problem when estimating the health effects of air pollution
Quantifying the impact of the modifiable areal unit problem when estimating the health effects of air pollution Open
Summary Air pollution is a major public health concern, and large numbers of epidemiological studies have been conducted to quantify its impacts. One study design used to quantify these impacts is a spatial areal unit design, which estimat…
View article: Multidimensional analysis of human intestinal fluid composition
Multidimensional analysis of human intestinal fluid composition Open
View article: Use of the online poisons information database TOXBASE and admissions rates for poisoned patients from emergency departments in England and Wales during 2008 to 2015
Use of the online poisons information database TOXBASE and admissions rates for poisoned patients from emergency departments in England and Wales during 2008 to 2015 Open
View article: RISIS Summer school Glasgow June 2019 - Materials
RISIS Summer school Glasgow June 2019 - Materials Open
This folder cointains all materials derived from RISIS Summer School on Data Science for Studying Science, Technology and Innovation which took place in Glasgow at University of Strathclyde. (Presentations, exercises, datasets materials)
View article: A statistical analysis of spatially linked time series using data from the TOXBASE database to study Emergency Department and NHS phone line management of poisoned patients
A statistical analysis of spatially linked time series using data from the TOXBASE database to study Emergency Department and NHS phone line management of poisoned patients Open