Kate Webb
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View article: Add in a virus: four cases of severe Kawasaki disease and concurrent adenovirus infection
Add in a virus: four cases of severe Kawasaki disease and concurrent adenovirus infection Open
View article: T Cell Receptor Repertoires Are Skewed in South African Patients With Multisystem Inflammatory Syndrome in Children
T Cell Receptor Repertoires Are Skewed in South African Patients With Multisystem Inflammatory Syndrome in Children Open
Multisystem inflammatory syndrome in children (MIS-C) is a severe response to SARS-CoV-2 that affects a small proportion of children. Overexpression of a nonspecific T cell receptor beta variable 11-2 in multiple populations has led to the…
View article: The landscape of inter-institutional and multinational collaborations in Kawasaki disease
The landscape of inter-institutional and multinational collaborations in Kawasaki disease Open
Objectives Integrated research potentiates evidence-based knowledge, particularly for uncommon diseases such as Kawasaki disease (KD). The 14th International Kawasaki Disease Symposium focussed on “Fostering global collaborations to solve …
View article: Cellular and soluble plasma immune markers at presentation in multisystem inflammatory syndrome in children and Kawasaki disease in South Africa: An observational study
Cellular and soluble plasma immune markers at presentation in multisystem inflammatory syndrome in children and Kawasaki disease in South Africa: An observational study Open
Immune and inflammatory alterations in multisystem inflammatory syndrome in children (MIS-C) as compared to Kawasaki disease (KD) were investigated in South Africa, a region of unique genetic background and high infectious disease burden. …
View article: Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa
Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa Open
Background Multisystem inflammatory syndrome in children (MIS-C) is a disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its short-term effects have been documented but little data exist on …
View article: Exploring the clinical profiles and management of juvenile dermatomyositis in Africa: a survey of African rheumatology care providers
Exploring the clinical profiles and management of juvenile dermatomyositis in Africa: a survey of African rheumatology care providers Open
View article: Baricitinib Treatment in <scp>RNU7</scp>‐1‐Associated Aicardi–Goutières Syndrome in a South African Child: A Case Report
Baricitinib Treatment in <span>RNU7</span>‐1‐Associated Aicardi–Goutières Syndrome in a South African Child: A Case Report Open
Aicardi–Goutières syndrome (AGS) is a rare monogenic type I interferonopathy. Janus kinase (JAK) inhibition has emerged as a potential treatment for AGS. RNU7‐1 is one of the most recently discovered genes for AGS, and the clinical effects…
View article: Childhood-Onset Systemic Lupus Erythematosus (cSLE): An International Perspective
Childhood-Onset Systemic Lupus Erythematosus (cSLE): An International Perspective Open
View article: Scurvy masquerading as IgA vasculitis
Scurvy masquerading as IgA vasculitis Open
Background Vitamin C deficiency, or scurvy, is rare but poses risks for children with poor diets, limited resources, or malabsorption issues. It may also be common in children with restrictive or selective dietary habits in children with g…
View article: Swissped-RECOVERY: masked independent adjudication for the interpretation of non-randomised treatment in a two-arm open-label randomised controlled trial (methylprednisolone vs immunoglobulins) in Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) involving 10 secondary and tertiary paediatric hospitals in Switzerland
Swissped-RECOVERY: masked independent adjudication for the interpretation of non-randomised treatment in a two-arm open-label randomised controlled trial (methylprednisolone vs immunoglobulins) in Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) involving 10 secondary and tertiary paediatric hospitals in Switzerland Open
Objectives In trials of acute severe infections or inflammations frequent administration of non-randomised treatment (ie, intercurrent event) in response to clinical events is expected. These events may affect the interpretation of trial f…
View article: Elevated risk for psychiatric outcomes in pediatric patients with Multisystem Inflammatory Syndrome (MIS-C): A review of neuroinflammatory and psychosocial stressors
Elevated risk for psychiatric outcomes in pediatric patients with Multisystem Inflammatory Syndrome (MIS-C): A review of neuroinflammatory and psychosocial stressors Open
View article: Comparing the immune abnormalities in MIS-C to healthy children and those with inflammatory disease reveals distinct inflammatory cytokine production and a monofunctional T cell response
Comparing the immune abnormalities in MIS-C to healthy children and those with inflammatory disease reveals distinct inflammatory cytokine production and a monofunctional T cell response Open
View article: Distinct T cell polyfunctional profile in SARS-CoV-2 seronegative children associated with endemic human coronavirus cross-reactivity
Distinct T cell polyfunctional profile in SARS-CoV-2 seronegative children associated with endemic human coronavirus cross-reactivity Open
View article: COVID-19 and MIS-C treatment in children—results from an international survey
COVID-19 and MIS-C treatment in children—results from an international survey Open
View article: Socioeconomic and Demographic Risk Factors for SARS-CoV-2 Seropositivity Among Healthcare Workers in a UK Hospital: A Prospective Cohort Study
Socioeconomic and Demographic Risk Factors for SARS-CoV-2 Seropositivity Among Healthcare Workers in a UK Hospital: A Prospective Cohort Study Open
Background To protect healthcare workers (HCWs) from the consequences of disease due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is necessary to understand the risk factors that drive exposure and infection within h…
View article: POS0371 DEVELOPMENT AND EVALUATION OF A TEXT-ANALYTICS ALGORITHM FOR AUTOMATED APPLICATION OF NATIONAL COVID-19 SHIELDING CRITERIA IN RHEUMATOLOGY PATIENTS
POS0371 DEVELOPMENT AND EVALUATION OF A TEXT-ANALYTICS ALGORITHM FOR AUTOMATED APPLICATION OF NATIONAL COVID-19 SHIELDING CRITERIA IN RHEUMATOLOGY PATIENTS Open
Background Efficient pandemic planning is a key for providing a timely response to any developing disease outbreak. For example, at the beginning of the current Coronavirus disease 2019 (COVID-19) pandemic, the UK's Scientific Committee is…
View article: Primary nephrotic syndrome in children in Cape Town, South Africa
Primary nephrotic syndrome in children in Cape Town, South Africa Open
Background. Histopathological patterns of childhood primary nephrotic syndrome (PNS) and clinical response to steroids have beenassociated with certain race groups in parts of South Africa. However, there are no recent studies of childhood…
View article: Distinct T cell functional profiles in SARS-CoV-2 seropositive and seronegative children associated with endemic human coronavirus cross-reactivity
Distinct T cell functional profiles in SARS-CoV-2 seropositive and seronegative children associated with endemic human coronavirus cross-reactivity Open
SUMMARY SARS-CoV-2 infection in children typically results in asymptomatic or mild disease. There is a paucity of studies on antiviral immunity in African children. We investigated SARS-CoV-2-specific T cell responses in 71 unvaccinated as…
View article: Distinct T Cell Functional Profiles in Sars-Cov-2 Seropositive and Seronegative Children Associated with Endemic Human Coronavirus Cross-Reactivity
Distinct T Cell Functional Profiles in Sars-Cov-2 Seropositive and Seronegative Children Associated with Endemic Human Coronavirus Cross-Reactivity Open
View article: 72 Distinguishing features of MIS-C to other paediatric febrile diseases in the acute setting
72 Distinguishing features of MIS-C to other paediatric febrile diseases in the acute setting Open
Background Multisystem inflammatory syndrome in children (MIS-C) presents with fever, shock, rash, abdominal pain and raised inflammatory markers, as well as common features of inflammatory childhood illnesses. In the acute setting, especi…
View article: 71 Estimation of incidence of MIS-C in Cape Town, South Africa
71 Estimation of incidence of MIS-C in Cape Town, South Africa Open
Background Multisystem inflammatory syndrome is a severe manifestation of SARS-CoV-2 in children. The incidence of MIS-C after SARS-CoV-2 infection is poorly understood. There are very few cohorts describing MIS-C in Africa despite MIS-C b…
View article: IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohort
IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohort Open
Introduction Multisystem inflammatory syndrome in children (MIS-C) is a severe acute inflammatory reaction to SARS-CoV-2 infection in children. There is a lack of data describing differential expression of immune genes in MIS-C compared to…
View article: The Impact of SARS-CoV-2 Variants on the Clinical Phenotype and Severity of Multisystem Inflammatory Syndrome in Children in South Africa
The Impact of SARS-CoV-2 Variants on the Clinical Phenotype and Severity of Multisystem Inflammatory Syndrome in Children in South Africa Open
The effects of SARS-CoV-2 variants on disease phenotype and severity of multisystem inflammatory syndrome in children (MIS-C) are unknown. We compared the clinical phenotype of MIS-C in 129 South African children across four distinct (Ance…
View article: Gender-Diverse Inclusion in Immunological Research: Benefits to Science and Health
Gender-Diverse Inclusion in Immunological Research: Benefits to Science and Health Open
The differences between male and female immune systems are an under-researched field, ripe for discovery. This is evidenced by the stark sex biases seen in autoimmunity and infectious disease. Both the sex hormones (oestrogen and testoster…
View article: The clinical features and estimated incidence of MIS-C in Cape Town, South Africa
The clinical features and estimated incidence of MIS-C in Cape Town, South Africa Open
View article: The Clinical Features and Estimated Incidence of MIS-C in Cape Town, South Africa
The Clinical Features and Estimated Incidence of MIS-C in Cape Town, South Africa Open
Background Multisystem inflammatory syndrome is a severe manifestation of SARS-CoV-2 in children. The incidence of MIS-C after infection is poorly understood. There are very few cohorts describing MIS-C in Africa despite MIS-C being more c…
View article: Clinical Features Which Distinguish Multisystem Inflammatory Syndrome from Severe Paediatric Febrile Disease in Cape Town, South Africa
Clinical Features Which Distinguish Multisystem Inflammatory Syndrome from Severe Paediatric Febrile Disease in Cape Town, South Africa Open
View article: Immediate effect of the COVID-19 pandemic on patient health, health-care use, and behaviours: results from an international survey of people with rheumatic diseases
Immediate effect of the COVID-19 pandemic on patient health, health-care use, and behaviours: results from an international survey of people with rheumatic diseases Open
View article: Long-Term Persistence of Spike Protein Antibody and Predictive Modeling of Antibody Dynamics After Infection With Severe Acute Respiratory Syndrome Coronavirus 2
Long-Term Persistence of Spike Protein Antibody and Predictive Modeling of Antibody Dynamics After Infection With Severe Acute Respiratory Syndrome Coronavirus 2 Open
Background Antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been shown to neutralize the virus in vitro and prevent disease in animal challenge models on reexposure. However, the current understanding of SARS…
View article: Pediatric rheumatology in Africa: thriving amidst challenges
Pediatric rheumatology in Africa: thriving amidst challenges Open