Katelyn T. Gause
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View article: Role of the Protein Corona Derived from Human Plasma in Cellular Interactions between Nanoporous Human Serum Albumin Particles and Endothelial Cells
Role of the Protein Corona Derived from Human Plasma in Cellular Interactions between Nanoporous Human Serum Albumin Particles and Endothelial Cells Open
The presence of a protein corona on various synthetic nanomaterials has been shown to strongly influence how they interact with cells. However, it is unclear if the protein corona also exists on protein particles, and if so, its role in pa…
View article: Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery
Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery Open
Despite the immense public health successes of immunization over the past century, effective vaccines are still lacking for globally important pathogens such as human immunodeficiency virus, malaria, and tuberculosis. Exciting recent advan…
View article: Codelivery of NOD2 and TLR9 Ligands via Nanoengineered Protein Antigen Particles for Improving and Tuning Immune Responses
Codelivery of NOD2 and TLR9 Ligands via Nanoengineered Protein Antigen Particles for Improving and Tuning Immune Responses Open
Vaccine adjuvants that can induce robust protective immunity are highly sought after for the development of safer and more effective vaccines. Vaccine formulation parameters that govern efficacy are still far from clear, such as the divers…
View article: Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens
Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens Open
Highly purified outer membrane vesicles (OMVs) of the periodontal pathogens, Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia were produced using tangential flow ultrafiltration, ultracentrifugation and Optiprep densi…
View article: Physicochemical and Immunological Assessment of Engineered Pure Protein Particles with Different Redox States
Physicochemical and Immunological Assessment of Engineered Pure Protein Particles with Different Redox States Open
The development of subunit antigen delivery formulations has become an important research endeavor, especially in cases where a whole cell vaccine approach has significant biosafety issues. Particle-based systems have shown particular effi…
View article: Physicochemical and immunological assessment of mesoporous silica-templated particles for vaccine delivery applications
Physicochemical and immunological assessment of mesoporous silica-templated particles for vaccine delivery applications Open
Routine vaccination was initiated in the early 20th century and is now considered one of the most beneficial health initiatives of all time. Despite their immense success, vaccines are often associated with safety concerns and there are st…