Katelynn M. Wilton
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View article: Linking immunodeficiency with lymphomagenesis: suboptimal T follicular subsets can drive DLBCL transformation 4761
Linking immunodeficiency with lymphomagenesis: suboptimal T follicular subsets can drive DLBCL transformation 4761 Open
Description Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy derived from transformed B cells of germinal center (GC) or post-GC origin. DLBCL incidence is elevated in immunodeficient persons with reduced T cells, such as …
View article: Lineage switch of B‐acute lymphoblastic leukemia with t(11;19)(q23;p13.3) into acute myeloid leukemia with monocytic differentiation after induction chemotherapy
Lineage switch of B‐acute lymphoblastic leukemia with t(11;19)(q23;p13.3) into acute myeloid leukemia with monocytic differentiation after induction chemotherapy Open
A 65-year old woman with dyspnea, headaches, and epistaxis presented with anemia (hemoglobin 7.7 g/dL) and thrombocytopenia (platelets 18×109/L) with a white blood cell (WBC) count of 4.0 × 109/L and 60% circulating blasts. Bone marrow bla…
View article: Erectile Dysfunction and Cardiovascular Risk in Men With Rheumatoid Arthritis: A Population-based Cohort Study
Erectile Dysfunction and Cardiovascular Risk in Men With Rheumatoid Arthritis: A Population-based Cohort Study Open
Objective. Both erectile dysfunction (ED) and rheumatoid arthritis (RA) are associated with increased cardiovascular (CV) risk. It is unknown if these diagnoses are associated or if their combination confers additional CV risk. We aimed to…
View article: Erectile Dysfunction in Men With Psoriatic Arthritis: A Population-based Cohort Study
Erectile Dysfunction in Men With Psoriatic Arthritis: A Population-based Cohort Study Open
Objective To define the incidence of erectile dysfunction (ED) in a population-based cohort of men with psoriatic arthritis (PsA). Methods Data pertaining to demographics, ED, and potential confounding diagnosis were extracted from a compr…
View article: The septin cytoskeleton regulates natural killer cell lytic granule release
The septin cytoskeleton regulates natural killer cell lytic granule release Open
Natural killer (NK) cell–mediated killing involves the membrane fusion of preformed lytic granules. While the roles of actin and microtubules are well accepted during this process, the function of septins, another cytoskeletal component th…
View article: Developmental brain abnormalities and acute encephalopathy in a patient with myopathy with extrapyramidal signs secondary to pathogenic variants in MICU1
Developmental brain abnormalities and acute encephalopathy in a patient with myopathy with extrapyramidal signs secondary to pathogenic variants in MICU1 Open
Mitochondria play a variety of roles in the cell, far beyond their widely recognized role in ATP generation. One such role is the regulation and sequestration of calcium, which is done with the help of the mitochondrial calcium uniporter (…
View article: Profound intellectual disability caused by homozygous TRAPPC9 pathogenic variant in a man from Malta
Profound intellectual disability caused by homozygous TRAPPC9 pathogenic variant in a man from Malta Open
Background Intellectual disability is a complex multi‐faceted condition with diverse underlying etiologies. One rare form of intellectual disability is secondary to the loss of TRAPPC9, an activator of NF‐κB and a mediator of intracellular…
View article: NK cell defects in X-linked pigmentary reticulate disorder
NK cell defects in X-linked pigmentary reticulate disorder Open
X-linked reticulate pigmentary disorder (XLPDR, Mendelian Inheritance in Man #301220) is a rare syndrome characterized by recurrent infections and sterile multiorgan inflammation. The syndrome is caused by an intronic mutation in POLA1, th…
View article: NKG2D–DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity
NKG2D–DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity Open
Natural killer (NK) cells eliminate abnormal cells through the release of cytolytic granule contents. In this process, NK cells must adhere to target cells through integrin-mediated adhesion, which is highly dependent on the generation of …
View article: The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network
The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network Open
Quantitative activity through the TCR-proximal protein network specifies thymic positive versus negative selection.
View article: VASP Regulates NK Cell Lytic Granule Convergence
VASP Regulates NK Cell Lytic Granule Convergence Open
NK cells eliminate viral-infected and malignant cells through a highly orchestrated series of cytoskeletal rearrangements, resulting in the release of cytolytic granule contents toward the target cell. Central to this process is the conver…
View article: Posttransplant autoimmune encephalitis
Posttransplant autoimmune encephalitis Open
The causes of encephalopathy in the posttransplant setting are diverse and include medication toxicity (e.g., posterior reversible encephalopathy syndrome), infections (e.g., human herpes virus type 6 [HHV-6]), and neoplastic disease (post…
View article: Risk of Obstructive Sleep Apnea and Its Association with Cardiovascular and Noncardiac Vascular Risk in Patients with Rheumatoid Arthritis: A Population-based Study
Risk of Obstructive Sleep Apnea and Its Association with Cardiovascular and Noncardiac Vascular Risk in Patients with Rheumatoid Arthritis: A Population-based Study Open
Objective. To define the incidence of obstructive sleep apnea (OSA) in patients with rheumatoid arthritis (RA) and determine whether OSA diagnosis predicts future cardiovascular disease (CVD) and noncardiac vascular events. Methods. Medica…