Katelynn S. Madill-Thomsen
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View article: Improving the histologic detection of donor-specific antibody-negative antibody-mediated rejection in kidney transplants
Improving the histologic detection of donor-specific antibody-negative antibody-mediated rejection in kidney transplants Open
Emerging treatments for antibody-mediated rejection (ABMR, NEJM391 (2):122-132) have increased the importance of ABMR detection when donor-specific antibody (DSA) is negative. We addressed this issue in the Trifecta-Kidney study (ClinicalT…
View article: Defining Relationships Among Tests for Kidney Transplant Antibody-Mediated Rejection
Defining Relationships Among Tests for Kidney Transplant Antibody-Mediated Rejection Open
The 4-way intertest correlations extend below current thresholds for diagnosing ABMR. These results map a network of 4 ABMR-related tests that can add precision to ABMR assessment in trials and clinical management, and highlight the need t…
View article: A cross-sectional study of the role of epithelial cell injury in kidney transplant outcomes
A cross-sectional study of the role of epithelial cell injury in kidney transplant outcomes Open
Genome Canada; Natera, Inc.; and Thermo Fisher Scientific.
View article: Relating the molecular phenotype of ulcerative colitis to the clinical course
Relating the molecular phenotype of ulcerative colitis to the clinical course Open
The expanding portfolio of targeted therapies for ulcerative colitis (UC) suggests that a more precise approach to defining disease activity will aid clinical decision-making. This prospective study used genome-wide microarrays to characte…
View article: Defining an NK Cell–enriched Rejection-like Phenotype in Liver Transplant Biopsies From the INTERLIVER Study
Defining an NK Cell–enriched Rejection-like Phenotype in Liver Transplant Biopsies From the INTERLIVER Study Open
Background. Initial analysis of liver transplant biopsies in the INTERLIVER study (ClinicalTrials.gov; unique identifier NCT03193151) using rejection-associated transcripts failed to find an antibody-mediated rejection state (ie, rich in n…
View article: Precision diagnostics in transplanted organs using microarray-assessed gene expression: concepts and technical methods of the Molecular Microscope® Diagnostic System (MMDx)
Precision diagnostics in transplanted organs using microarray-assessed gene expression: concepts and technical methods of the Molecular Microscope® Diagnostic System (MMDx) Open
There is a major unmet need for improved accuracy and precision in the assessment of transplant rejection and tissue injury. Diagnoses relying on histologic and visual assessments demonstrate significant variation between expert observers …
View article: Comparing Plasma Donor–derived Cell-free DNA to Gene Expression in Endomyocardial Biopsies in the Trifecta-Heart Study
Comparing Plasma Donor–derived Cell-free DNA to Gene Expression in Endomyocardial Biopsies in the Trifecta-Heart Study Open
Background. Plasma donor–derived cell-free DNA (dd-cfDNA) is used to screen for rejection in heart transplants. We launched the Trifecta-Heart study (ClinicalTrials.gov No. NCT04707872), an investigator-initiated, prospective trial, to exa…
View article: Redefining the molecular rejection states in 3230 heart transplant biopsies: Relationships to parenchymal injury and graft survival
Redefining the molecular rejection states in 3230 heart transplant biopsies: Relationships to parenchymal injury and graft survival Open
The first-generation Molecular Microscope (MMDx) system for heart transplant endomyocardial biopsies used expression of rejection-associated transcripts (RATs) to diagnose not only T cell-mediated rejection (TCMR) and antibody-mediated rej…
View article: Distinct Molecular Processes Mediate Donor-derived Cell-free DNA Release From Kidney Transplants in Different Disease States
Distinct Molecular Processes Mediate Donor-derived Cell-free DNA Release From Kidney Transplants in Different Disease States Open
Background. Among all biopsies in the Trifecta-Kidney Study (ClinicalTrials.gov NCT04239703), elevated plasma donor-derived cell-free DNA (dd-cfDNA) correlated most strongly with molecular antibody–mediated rejection (AMR) but was also ele…
View article: Molecular states associated with dysfunction and graft loss in heart transplants
Molecular states associated with dysfunction and graft loss in heart transplants Open
View article: Using Regression Equations to Enhance Interpretation of Histology Lesions of Kidney Transplant Rejection
Using Regression Equations to Enhance Interpretation of Histology Lesions of Kidney Transplant Rejection Open
Background. The Banff system for histologic diagnosis of rejection in kidney transplant biopsies uses guidelines to assess designated features—lesions, donor-specific antibody (DSA), and C4d staining. We explored whether using regression e…
View article: The Molecular Phenotype of Kidney Transplants: Insights From the MMDx Project
The Molecular Phenotype of Kidney Transplants: Insights From the MMDx Project Open
This review outlines the molecular disease states in kidney transplant biopsies as documented in the development of the Molecular Microscope Diagnostic System (MMDx). These states include T cell–mediated rejection (TCMR), antibody-mediated…
View article: Relating Molecular T Cell–mediated Rejection Activity in Kidney Transplant Biopsies to Time and to Histologic Tubulitis and Atrophy-fibrosis
Relating Molecular T Cell–mediated Rejection Activity in Kidney Transplant Biopsies to Time and to Histologic Tubulitis and Atrophy-fibrosis Open
Background. We studied the variation in molecular T cell–mediated rejection (TCMR) activity in kidney transplant indication biopsies and its relationship with histologic lesions (particularly tubulitis and atrophy-fibrosis) and time posttr…
View article: Antibody-mediated Rejection Without Detectable Donor-specific Antibody Releases Donor-derived Cell-free DNA: Results From the Trifecta Study
Antibody-mediated Rejection Without Detectable Donor-specific Antibody Releases Donor-derived Cell-free DNA: Results From the Trifecta Study Open
Background. Trifecta (ClinicalTrials.gov #NCT04239703) is a prospective trial defining relationships between donor-derived cell-free DNA (dd-cfDNA), donor-specific antibody (DSA), and molecular findings in kidney transplant biopsies. Previ…
View article: Combining Donor-derived Cell-free DNA Fraction and Quantity to Detect Kidney Transplant Rejection Using Molecular Diagnoses and Histology as Confirmation
Combining Donor-derived Cell-free DNA Fraction and Quantity to Detect Kidney Transplant Rejection Using Molecular Diagnoses and Histology as Confirmation Open
Background. Donor-derived cell-free DNA (dd-cfDNA) fraction and quantity have both been shown to be associated with allograft rejection. The present study compared the relative predictive power of each of these variables to the combination…
View article: Molecular diagnosis of ABMR with or without donor-specific antibody in kidney transplant biopsies: Differences in timing and intensity but similar mechanisms and outcomes
Molecular diagnosis of ABMR with or without donor-specific antibody in kidney transplant biopsies: Differences in timing and intensity but similar mechanisms and outcomes Open
View article: Archetypal Analysis of Injury in Kidney Transplant Biopsies Identifies Two Classes of Early AKI
Archetypal Analysis of Injury in Kidney Transplant Biopsies Identifies Two Classes of Early AKI Open
All transplanted kidneys are subjected to some degree of injury as a result of the donation-implantation process and various post-transplant stresses such as rejection. Because transplants are frequently biopsied, they present an opportuni…
View article: A160 MOLECULAR ANALYSIS OF THE INJURY-REPAIR RESPONSE IN ULCERATIVE COLITIS REVEALS HETEROGENEITY IN DISEASE ACTIVIT
A160 MOLECULAR ANALYSIS OF THE INJURY-REPAIR RESPONSE IN ULCERATIVE COLITIS REVEALS HETEROGENEITY IN DISEASE ACTIVIT Open
Background Ulcerative colitis (UC) is a chronic inflammatory condition affecting the colonic epithelium. We used an established microarray-based system to analyze a set of 128 UC biopsies (113 patients), assessing gene expression associate…
View article: A57 ULCERATIVE COLITIS DISEASE ACTIVITY IS DOMINATED BY INNATE IMMUNITY AND FEATURES OF TISSUE REMODELING
A57 ULCERATIVE COLITIS DISEASE ACTIVITY IS DOMINATED BY INNATE IMMUNITY AND FEATURES OF TISSUE REMODELING Open
Background Ulcerative colitis (UC) is a chronic inflammatory condition affecting the colonic epithelium, with potential roles for the inflammasome, complement activation, T cells, and the microbiome in pathogenesis. We applied an establish…
View article: Donor-Specific Antibody Is Associated with Increased Expression of Rejection Transcripts in Renal Transplant Biopsies Classified as No Rejection
Donor-Specific Antibody Is Associated with Increased Expression of Rejection Transcripts in Renal Transplant Biopsies Classified as No Rejection Open
Significance Statement Many kidney transplant patients in INTERCOMEX whose biopsy specimens are diagnosed molecularly or histologically as no rejection have donor-specific HLA antibodies (DSAs, 32%). Although the significance of DSA in no …
View article: Author Correction: Molecular patterns of isolated tubulitis differ from tubulitis with interstitial inflammation in early indication biopsies of kidney allografts
Author Correction: Molecular patterns of isolated tubulitis differ from tubulitis with interstitial inflammation in early indication biopsies of kidney allografts Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Molecular patterns of isolated tubulitis differ from tubulitis with interstitial inflammation in early indication biopsies of kidney allografts
Molecular patterns of isolated tubulitis differ from tubulitis with interstitial inflammation in early indication biopsies of kidney allografts Open
View article: The Molecular Microscope® Diagnostic System meets eminence-based medicine: A clinician’s perspective
The Molecular Microscope® Diagnostic System meets eminence-based medicine: A clinician’s perspective Open
View article: Discrepancy analysis comparing molecular and histology diagnoses in kidney transplant biopsies
Discrepancy analysis comparing molecular and histology diagnoses in kidney transplant biopsies Open
Discrepancy analysis comparing two diagnostic platforms offers potential insights into both without assuming either is always correct. Having optimized the Molecular Microscope Diagnostic System (MMDx) in renal transplant biopsies, we stud…
View article: Generating automated kidney transplant biopsy reports combining molecular measurements with ensembles of machine learning classifiers
Generating automated kidney transplant biopsy reports combining molecular measurements with ensembles of machine learning classifiers Open
We previously reported a system for assessing rejection in kidney transplant biopsies using microarray-based gene expression data, the Molecular Microscope® Diagnostic System (MMDx). The present study was designed to optimize th…
View article: Molecular phenotype of kidney transplant indication biopsies with inflammation in scarred areas
Molecular phenotype of kidney transplant indication biopsies with inflammation in scarred areas Open
View article: A70 MOLECULAR ARCHETYPE HETEROGENEITY IN ULCERATIVE COLITIS BIOPSIES
A70 MOLECULAR ARCHETYPE HETEROGENEITY IN ULCERATIVE COLITIS BIOPSIES Open
BACKGROUND: The assessment of patients with ulcerative colitis (UC) remains a challenge despite rapidly evolving medical therapy. Current assessment with endoscopic scoring and histopathology lacks the granularity to correlate strongly wit…
View article: A69 THE MOLECULAR LANDSCAPE IN ULCERATIVE COLITIS
A69 THE MOLECULAR LANDSCAPE IN ULCERATIVE COLITIS Open
BACKGROUND: Ulcerative colitis (UC) is a chronic, idiopathic inflammatory condition affecting the colonic epithelium, with the inflammasome, T cells, complement activation, and microbiome dysbiosis contributing to pathogenesis. AIMS: We ap…
View article: Review: The transcripts associated with organ allograft rejection
Review: The transcripts associated with organ allograft rejection Open
View article: The Effect of Cortex/Medulla Proportions on Molecular Diagnoses in Kidney Transplant Biopsies: Rejection and Injury Can Be Assessed in Medulla
The Effect of Cortex/Medulla Proportions on Molecular Diagnoses in Kidney Transplant Biopsies: Rejection and Injury Can Be Assessed in Medulla Open