Kateřina Amruz Černá
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View article: Taurine Inhibits Apolipoprotein E4 Aggregation
Taurine Inhibits Apolipoprotein E4 Aggregation Open
Apolipoprotein E4 (ApoE4) is a major genetic risk factor in many neurodegenerative diseases, yet effective therapeutic strategies targeting its associated pathologies remain unresolved. The aggregation of ApoE4, a key pathological feature,…
View article: The Alzheimer’s-Associated <i>SORL1</i> p.Y1816C Variant Impairs APP Sorting, Axonal Trafficking, and Neuronal Activity in iPSC-Derived Brain Models
The Alzheimer’s-Associated <i>SORL1</i> p.Y1816C Variant Impairs APP Sorting, Axonal Trafficking, and Neuronal Activity in iPSC-Derived Brain Models Open
Background SORL1 , encoding the sorting receptor SORLA, is now recognized as the fourth autosomal dominant Alzheimer’s disease (AD) gene. Loss of SORLA function is known to disrupt endosomal trafficking and enhance amyloidogenic APP proces…
View article: Viral Infection Induces Alzheimer’s Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models
Viral Infection Induces Alzheimer’s Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models Open
Structured Abstract INTRODUCTION The Pathogen Infection Hypothesis proposes that β-Amyloid (Aβ) functions as an antimicrobial peptide, with pathogen-induced aggregation potentially contributing to Alzheimer’s disease (AD) pathology. METHOD…
View article: Cerebral organoids derived from patients with Alzheimer’s disease with PSEN1/2 mutations have defective tissue patterning and altered development
Cerebral organoids derived from patients with Alzheimer’s disease with PSEN1/2 mutations have defective tissue patterning and altered development Open
View article: Light-responsive microRNA molecules in human retinal organoids are differentially regulated by distinct wavelengths of light
Light-responsive microRNA molecules in human retinal organoids are differentially regulated by distinct wavelengths of light Open
Cells in the human retina must rapidly adapt to constantly changing visual stimuli. This fast adaptation to varying levels and wavelengths of light helps to regulate circadian rhythms and allows for adaptation to high levels of illuminatio…
View article: Heteromated Decision-Making: Integrating Socially Assistive Robots in Care Relationships
Heteromated Decision-Making: Integrating Socially Assistive Robots in Care Relationships Open
Technological development continues to advance, with consequences for the use of robots in health care. For this reason, this workshop contribution aims at consideration of how socially assistive robots can be integrated into care and what…
View article: MicroRNA Profiling of Self-Renewing Human Neural Stem Cells Reveals Novel Sets of Differentially Expressed microRNAs During Neural Differentiation In Vitro
MicroRNA Profiling of Self-Renewing Human Neural Stem Cells Reveals Novel Sets of Differentially Expressed microRNAs During Neural Differentiation In Vitro Open
The involvement of microRNAs (miRNAs) in orchestrating self-renewal and differentiation of stem cells has been revealed in a number of recent studies. And while in human pluripotent stem cells, miRNAs have been directly linked to the core …
View article: Light-Responsive MicroRNAs in Human Retinal Tissue are Differentially Regulated by Distinct Wavelengths of Light
Light-Responsive MicroRNAs in Human Retinal Tissue are Differentially Regulated by Distinct Wavelengths of Light Open
Retinal microRNA (miRNA) molecules play critical roles in a wide range of processes including cell proliferation, cell death, and synaptic plasticity. Recently they have been shown to regulate crucial processes that are associated with per…
View article: Glioblastoma and cerebral organoids: development and analysis of an <i>in vitro</i> model for glioblastoma migration
Glioblastoma and cerebral organoids: development and analysis of an <i>in vitro</i> model for glioblastoma migration Open
It is currently challenging to adequately model the growth and migration of glioblastoma using two‐dimensional (2D) in vitro culture systems as they quickly lose the original, patient‐specific identity and heterogeneity. However, with the …
View article: Light-Responsive MicroRNA Molecules in Human Retinal Tissue Are Differentially Regulated by Distinct Wavelengths of Light
Light-Responsive MicroRNA Molecules in Human Retinal Tissue Are Differentially Regulated by Distinct Wavelengths of Light Open
View article: P133 Point-of-care measurement of infliximab and adalimumab trough levels by the fluorescence resonance energy transfer (FRET) assay
P133 Point-of-care measurement of infliximab and adalimumab trough levels by the fluorescence resonance energy transfer (FRET) assay Open
Background Therapeutic drug monitoring (TDM) is the clinical practice of measuring serum drug concentrations to guide clinical decision-making. In IBD patients, it is applied mainly in infliximab (IFX) and adalimumab (ADL) therapy. TDM is …
View article: Transformation of HCI co-research with older adults - researchers’ positionality in the COVID-19 pandemic times
Transformation of HCI co-research with older adults - researchers’ positionality in the COVID-19 pandemic times Open
In the time of COVID-19, many measurements to contain the pandemic contributed to social isolation and loneliness. Older adults in particular experience various forms of ageism in this regard, for example by being stereotyped as digitally …
View article: IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3Kδ inhibitor idelalisib
IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3Kδ inhibitor idelalisib Open
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View article: FoxO1-GAB1 axis regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia
FoxO1-GAB1 axis regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia Open
Recirculation of chronic lymphocytic leukemia (CLL) cells between the peripheral blood and lymphoid niches plays a critical role in disease pathophysiology, and inhibiting this process is one of the major mechanisms of action for B-cell re…
View article: <i>miR-29</i> modulates CD40 signaling in chronic lymphocytic leukemia by targeting TRAF4: an axis affected by BCR inhibitors
<i>miR-29</i> modulates CD40 signaling in chronic lymphocytic leukemia by targeting TRAF4: an axis affected by BCR inhibitors Open
B-cell receptor (BCR) signaling and T-cell interactions play a pivotal role in chronic lymphocytic leukemia (CLL) pathogenesis and disease aggressiveness. CLL cells can use microRNAs (miRNAs) and their targets to modulate microenvironmenta…
View article: Oct4-mediated reprogramming induces embryonic-like microRNA expression signatures in human fibroblasts
Oct4-mediated reprogramming induces embryonic-like microRNA expression signatures in human fibroblasts Open
View article: p53 limits B cell receptor (BCR) signalling: a new role for <i>miR-34a</i> and FOXP1
p53 limits B cell receptor (BCR) signalling: a new role for <i>miR-34a</i> and FOXP1 Open
View article: miR-150 downregulation contributes to the high-grade transformation of follicular lymphoma by upregulating FOXP1 levels
miR-150 downregulation contributes to the high-grade transformation of follicular lymphoma by upregulating FOXP1 levels Open
Follicular lymphoma (FL) is a common indolent B-cell malignancy with a variable clinical course. An unfavorable event in its course is histological transformation to a high-grade lymphoma, typically diffuse large B-cell lymphoma. Recent st…
View article: DOWN‐REGULATION OF MI<scp>R</scp>‐150 AND UP‐REGULATION OF ITS TARGET <scp>FOXP</scp>1 IS ASSOCIATED WITH TRANSFORMATION OF FOLLICULAR LYMPHOMA
DOWN‐REGULATION OF MI<span>R</span>‐150 AND UP‐REGULATION OF ITS TARGET <span>FOXP</span>1 IS ASSOCIATED WITH TRANSFORMATION OF FOLLICULAR LYMPHOMA Open
Introduction: We aim to understand the role of microRNAs (miRNAs) in the high-grade transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL). Recently, a number of genomic aberrations associated with transformed …
View article: Ibrutinib inhibits CD20 upregulation on CLL B cells mediated by the CXCR4/SDF-1 axis
Ibrutinib inhibits CD20 upregulation on CLL B cells mediated by the CXCR4/SDF-1 axis Open
Key Points Microenvironmental interactions upregulate CD20 expression in CLL cells through the CXCR4/SDF-1 axis. Ibrutinib treatment causes downregulation of CD20 in CLL cells.