Katharina Bottermann
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View article: Obesity and diabetes related disturbances in systemic metabolism induce a cardiometabolic heart failure with preserved ejection fraction phenotype in a combined high-fat, high sucrose diet and streptozotocin mouse model
Obesity and diabetes related disturbances in systemic metabolism induce a cardiometabolic heart failure with preserved ejection fraction phenotype in a combined high-fat, high sucrose diet and streptozotocin mouse model Open
Background Diabetes and obesity are associated with an increased incidence of heart failure with preserved ejection fraction (HFpEF), but the underlying pathophysiological mechanisms are poorly understood. A shortage of appropriate preclin…
View article: Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration
Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration Open
Despite its promise, cardiac regenerative therapy remains clinically elusive due to the difficulty of spatio‐temporal control of proliferative induction, and the need to coordinately reprogram multiple regulatory pathways to overcome the s…
View article: Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity
Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity Open
Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide prevalence. Understanding the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological int…
View article: Combinatorial miRNA1a/15b interference drives adult cardiac regeneration
Combinatorial miRNA1a/15b interference drives adult cardiac regeneration Open
BACKGROUND Despite its promise, cardiac regenerative therapy remains clinically elusive due to the difficulty of spatio-temporal control of proliferative induction, and the need to coordinately reprogram multiple regulatory pathways to ove…
View article: Cardiac ischemia modulates white adipose tissue in a depot-specific manner
Cardiac ischemia modulates white adipose tissue in a depot-specific manner Open
The incidence of heart failure after myocardial infarction (MI) remains high and the underlying causes are incompletely understood. The crosstalk between heart and adipose tissue and stimulated lipolysis has been identified as potential dr…
View article: Cardiomyocyte p38 MAPKα suppresses a heart–adipose tissue–neutrophil crosstalk in heart failure development
Cardiomyocyte p38 MAPKα suppresses a heart–adipose tissue–neutrophil crosstalk in heart failure development Open
Although p38 MAP Kinase α (p38 MAPKα) is generally accepted to play a central role in the cardiac stress response, to date its function in maladaptive cardiac hypertrophy is still not unambiguously defined. To induce a pathological type of…
View article: Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease
Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease Open
Dataset from Bischof C, Mirtschink P, Yuan T, Wu M, Zhu C, Kaur J, Pham MD, Gonzalez-Gonoggia S, Hammer M, Rogg EM, Sharma R, Bottermann K, Gercken B, Hagag E, Berthonneche C, Sossalla S, Stehr SN, Maxeiner J, Duda MA, Latreille M, Zamboni…
View article: Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease
Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease Open
Dataset from Bischof C, Mirtschink P, Yuan T, Wu M, Zhu C, Kaur J, Pham MD, Gonzalez-Gonoggia S, Hammer M, Rogg EM, Sharma R, Bottermann K, Gercken B, Hagag E, Berthonneche C, Sossalla S, Stehr SN, Maxeiner J, Duda MA, Latreille M, Zamboni…
View article: 4-hydroxytamoxifen does not deteriorate cardiac function in cardiomyocyte-specific MerCreMer transgenic mice
4-hydroxytamoxifen does not deteriorate cardiac function in cardiomyocyte-specific MerCreMer transgenic mice Open
Conditional, cell-type-specific transgenic mouse lines are of high value in cardiovascular research. A standard tool for cardiomyocyte-restricted DNA editing is the αMHC-MerCreMer/loxP system. However, there is an ongoing debate on the occ…
View article: Adipocyte lipolysis drives acute stress-induced insulin resistance
Adipocyte lipolysis drives acute stress-induced insulin resistance Open
Stress hyperglycemia and insulin resistance are evolutionarily conserved metabolic adaptations to severe injury including major trauma, burns, or hemorrhagic shock (HS). In response to injury, the neuroendocrine system increases secretion …
View article: Dissection of heterocellular cross-talk in vascularized cardiac tissue mimetics
Dissection of heterocellular cross-talk in vascularized cardiac tissue mimetics Open
Cellular specialization and interaction with other cell types in cardiac tissue is essential for the coordinated function of cell populations in the heart. The complex interplay between cardiomyocytes, endothelial cells and fibroblasts is …
View article: Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice
Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice Open
View article: <i>Klf4</i> has an unexpected protective role in perivascular cells within the microvasculature
<i>Klf4</i> has an unexpected protective role in perivascular cells within the microvasculature Open
Recent smooth muscle cell (SMC) lineage-tracing studies have revealed that SMCs undergo remarkable changes in phenotype during development of atherosclerosis. Of major interest, we demonstrated that Kruppel-like factor 4 (KLF4) in SMCs is …
View article: Adaptive Ventricular Remodelling after Myocardial Infarction Involves Titin-Based Cardiomyocyte Stiffening and Elevated Titin Turnover
Adaptive Ventricular Remodelling after Myocardial Infarction Involves Titin-Based Cardiomyocyte Stiffening and Elevated Titin Turnover Open
View article: Titin-Based Cardiac Myocyte Stiffening Contributes to Early Adaptive Ventricular Remodeling After Myocardial Infarction
Titin-Based Cardiac Myocyte Stiffening Contributes to Early Adaptive Ventricular Remodeling After Myocardial Infarction Open
Rationale: Myocardial infarction (MI) increases the wall stress in the viable myocardium and initiates early adaptive remodeling in the left ventricle to maintain cardiac output. Later remodeling processes include fibrotic reorganization t…