Katharina F. Hohmann
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View article: A Protonated Cytidine Stabilizes the Ligand‐Binding Pocket in the PreQ<sub>1</sub> Riboswitch in Thermophilic Bacteria
A Protonated Cytidine Stabilizes the Ligand‐Binding Pocket in the PreQ<sub>1</sub> Riboswitch in Thermophilic Bacteria Open
Riboswitches are bacterial mRNA structure elements regulating either transcription or translation of downstream genes in response to high‐affinity binding of a low molecular weight ligand. Among this diverse group of RNA structures, the cl…
View article: Comprehensive Fragment Screening of the SARS‐CoV‐2 Proteome Explores Novel Chemical Space for Drug Development
Comprehensive Fragment Screening of the SARS‐CoV‐2 Proteome Explores Novel Chemical Space for Drug Development Open
SARS‐CoV‐2 (SCoV2) and its variants of concern pose serious challenges to the public health. The variants increased challenges to vaccines, thus necessitating for development of new intervention strategies including anti‐virals. Within the…
View article: Comprehensive Fragment Screening of the SARS‐CoV‐2 Proteome Explores Novel Chemical Space for Drug Development
Comprehensive Fragment Screening of the SARS‐CoV‐2 Proteome Explores Novel Chemical Space for Drug Development Open
SARS‐CoV‐2 (SCoV2) and its variants of concern pose serious challenges to the public health. The variants increased challenges to vaccines, thus necessitating for development of new intervention strategies including anti‐virals. Within the…
View article: 1H, 13C and 15N chemical shift assignment of the stem-loops 5b + c from the 5′-UTR of SARS-CoV-2
1H, 13C and 15N chemical shift assignment of the stem-loops 5b + c from the 5′-UTR of SARS-CoV-2 Open
View article: Short-chain aurachin D derivatives are selective inhibitors of E. coli cytochrome bd-I and bd-II oxidases
Short-chain aurachin D derivatives are selective inhibitors of E. coli cytochrome bd-I and bd-II oxidases Open
View article: The RNA chaperone StpA enables fast RNA refolding by destabilization of mutually exclusive base pairs within competing secondary structure elements
The RNA chaperone StpA enables fast RNA refolding by destabilization of mutually exclusive base pairs within competing secondary structure elements Open
In bacteria RNA gene regulatory elements refold dependent on environmental clues between two or more long-lived conformational states each associated with a distinct regulatory state. The refolding kinetics are strongly temperature-depende…
View article: 1H, 13C and 15N assignment of stem-loop SL1 from the 5'-UTR of SARS-CoV-2
1H, 13C and 15N assignment of stem-loop SL1 from the 5'-UTR of SARS-CoV-2 Open
View article: Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS‐CoV‐2 Genome
Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS‐CoV‐2 Genome Open
SARS‐CoV‐2 contains a positive single‐stranded RNA genome of approximately 30 000 nucleotides. Within this genome, 15 RNA elements were identified as conserved between SARS‐CoV and SARS‐CoV‐2. By nuclear magnetic resonance (NMR) spectrosco…
View article: Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS‐CoV‐2 Genome
Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS‐CoV‐2 Genome Open
SARS‐CoV‐2 contains a positive single‐stranded RNA genome of approximately 30 000 nucleotides. Within this genome, 15 RNA elements were identified as conserved between SARS‐CoV and SARS‐CoV‐2. By nuclear magnetic resonance (NMR) spectrosco…
View article: Correction to ‘Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy’
Correction to ‘Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy’ Open
View article: Real-time nuclear magnetic resonance spectroscopy in the study of biomolecular kinetics and dynamics
Real-time nuclear magnetic resonance spectroscopy in the study of biomolecular kinetics and dynamics Open
The review describes the application of nuclear magnetic resonance (NMR) spectroscopy to study kinetics of folding, refolding and aggregation of proteins, RNA and DNA. Time-resolved NMR experiments can be conducted in a reversible or an ir…
View article: Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications
Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications Open
The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses a severe threat to humanity and demands the redirection of scientific efforts and criteria to organized research projects. The international COVID19-NMR …
View article: 1H, 13C, 15N and 31P chemical shift assignment for stem-loop 4 from the 5′-UTR of SARS-CoV-2
1H, 13C, 15N and 31P chemical shift assignment for stem-loop 4 from the 5′-UTR of SARS-CoV-2 Open
View article: Real-time NMR spectroscopy in the study of biomolecular kineticsand dynamics
Real-time NMR spectroscopy in the study of biomolecular kineticsand dynamics Open
The review describes the application of NMR spectroscopy to study kinetics of folding, refolding and aggregation of proteins, RNA and DNA. Time-resolved NMR experiments can be conducted in a reversible or an irreversible manner. In particu…
View article: 1H, 13C and 15N chemical shift assignment of the stem-loop 5a from the 5′-UTR of SARS-CoV-2
1H, 13C and 15N chemical shift assignment of the stem-loop 5a from the 5′-UTR of SARS-CoV-2 Open
The SARS-CoV-2 (SCoV-2) virus is the causative agent of the ongoing COVID-19 pandemic. It contains a positive sense single-stranded RNA genome and belongs to the genus of Betacoronaviruses. The 5′- and 3′-genomic ends of the 30 kb SCoV-2 g…
View article: Iminoboronates as Dual‐Purpose Linkers in Chemical Probe Development
Iminoboronates as Dual‐Purpose Linkers in Chemical Probe Development Open
Chemical probes that covalently modify proteins of interest are powerful tools for the research of biological processes. Important in the design of a probe is the choice of reactive group that forms the covalent bond, as it decides the suc…
View article: Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy
Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy Open
The current pandemic situation caused by the Betacoronavirus SARS-CoV-2 (SCoV2) highlights the need for coordinated research to combat COVID-19. A particularly important aspect is the development of medication. In addition to viral protein…
View article: CCDC 1966615: Experimental Crystal Structure Determination
CCDC 1966615: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate‐Based Inhibitors of Cytochrome <i>bo<sub>3</sub></i> Ubiquinol Oxidase from <i>Escherichia coli</i>
Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate‐Based Inhibitors of Cytochrome <i>bo<sub>3</sub></i> Ubiquinol Oxidase from <i>Escherichia coli</i> Open
The respiratory chain of Escherichia coli contains two different types of terminal oxidase that are differentially regulated as a response to changing environmental conditions. These oxidoreductases catalyze the reduction of molecular oxyg…
View article: Introduction: Ghost Factory
Introduction: Ghost Factory Open
Topographies of the Obsolete is an artistic research project conceived in 2012 by University of Bergen Professors Neil Brownsword and Anne Helen Mydland, in collaboration with six European HEI’s and the British Ceramics Biennial. Emerging …
View article: An <i>in situ</i> combinatorial methodology to synthesize and screen chemical probes
An <i>in situ</i> combinatorial methodology to synthesize and screen chemical probes Open
Linking of reactive groups and ligands by imine chemistry provides chemical probes that label proteins of interest.
View article: Enzymatic Polymerization of Dimethyl 2,5-Furandicarboxylate and Heteroatom Diamines
Enzymatic Polymerization of Dimethyl 2,5-Furandicarboxylate and Heteroatom Diamines Open
Previously, we have synthesized a diverse range of 2,5-furandicarboxylic acid (FDCA)-based semiaromatic polyamides via enzymatic polymerization. This novel class of polymers are biobased alternatives to polyphthalamides, which are petrol-b…
View article: Das Potential narrativer Computerspiele für die Förderung des literarischen Lernens im Fremdsprachenunterricht
Das Potential narrativer Computerspiele für die Förderung des literarischen Lernens im Fremdsprachenunterricht Open