Anna Katharina Simon
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View article: Autophagy-regulated mitochondrial inheritance controls early CD8+ T cell fate commitment
Autophagy-regulated mitochondrial inheritance controls early CD8+ T cell fate commitment Open
T cell immunity deteriorates with age, accompanied by a decline in autophagy and asymmetric cell division. Here we show that autophagy regulates mitochondrial inheritance in CD8 + T cells. Using a mouse model that enables sequential taggin…
View article: Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling
Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling Open
A hallmark of obesity is a pathological expansion of white adipose tissue (WAT), accompanied by marked tissue dysfunction and fibrosis. Autophagy promotes adipocyte differentiation and lipid homeostasis, but its role in obese adipocytes an…
View article: Rapamycin exerts its geroprotective effects in the ageing human immune system by enhancing resilience against DNA damage
Rapamycin exerts its geroprotective effects in the ageing human immune system by enhancing resilience against DNA damage Open
mTOR inhibitors such as rapamycin are among the most robust life-extending interventions known, yet the mechanisms underlying their geroprotective effects in humans remain incompletely understood. At non-immunosuppressive doses, these drug…
View article: Can a Conference be Epidemiologically Conscious? A Pilot Study of Implementing COVID-19 Mitigation Measures at an In-Person Conference
Can a Conference be Epidemiologically Conscious? A Pilot Study of Implementing COVID-19 Mitigation Measures at an In-Person Conference Open
Structed Abstract Introduction : Public health guidance about respiratory agents often focuses on the county level, overlooking local events that may increase transmission—such as conferences. Objectives: To understand conference-level mit…
View article: Calcium regulation of muscle spindle mechanosensory afferent function
Calcium regulation of muscle spindle mechanosensory afferent function Open
Extracellular calcium is crucial for the normal function of muscle spindle sensory afferents. They express multiple calcium buffering proteins. Extracellular calcium is essential for recycling of synaptic‐like vesicles (SLVs) in the termin…
View article: Autophagy selectively clears ER in inflammation-induced muscle atrophy
Autophagy selectively clears ER in inflammation-induced muscle atrophy Open
Skeletal muscle atrophy is a pathological condition characterized by the progressive loss of muscle mass and function, driven by factors such as disuse, inflammation, and aging. While the ubiquitin-proteasome system is established as the c…
View article: Mitochondrial heteroplasmy disrupts osteoclast differentiation and bone resorption by impairing respiratory complex I
Mitochondrial heteroplasmy disrupts osteoclast differentiation and bone resorption by impairing respiratory complex I Open
Mitochondrial heteroplasmy, the co-existence of different mitochondrial genomes within a cell, is linked to aging and disease. Patients with heteroplasmy due to mitochondrial mutations experience multiple organ complications, particularly …
View article: Spermidine Mitigates Immune Cell Senescence, Enhances Autophagy, and Boosts Vaccine Responses in Healthy Older Adults.
Spermidine Mitigates Immune Cell Senescence, Enhances Autophagy, and Boosts Vaccine Responses in Healthy Older Adults. Open
Older adults are particularly vulnerable to infectious diseases, and vaccines are often less effective in this population due to immunosenescence, which is characterized by diminished B and T memory responses. Autophagy is believed to unde…
View article: Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity
Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity Open
The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at th…
View article: Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling
Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling Open
A hallmark of obesity is a pathological expansion of white adipose tissue (WAT), accompanied by marked tissue dysfunction and fibrosis. Autophagy promotes adipocyte differentiation and lipid homeostasis, but its role in obese adipocytes an…
View article: Inheritance of old mitochondria controls early CD8<sup>+</sup>T cell fate commitment and is regulated by autophagy
Inheritance of old mitochondria controls early CD8<sup>+</sup>T cell fate commitment and is regulated by autophagy Open
T cell immunity is impaired during ageing, particularly in memory responses needed for efficient vaccination. Autophagy and asymmetric cell division (ACD) are cell biological mechanisms key to memory formation, which undergo a decline upon…
View article: Blocking glycosphingolipid production alters autophagy in osteoclasts and improves myeloma bone disease
Blocking glycosphingolipid production alters autophagy in osteoclasts and improves myeloma bone disease Open
Glycosphingolipids (GSLs) are key constituents of membrane bilayers playing a role in structural integrity, cell signalling in microdomains, endosomes and lysosomes, and cell death pathways. Conversion of ceramide into GSLs is controlled b…
View article: Proteostasis in T cell aging
Proteostasis in T cell aging Open
Aging leads to a decline in immune cell function, which leaves the organism vulnerable to infections and age-related multimorbidities. One major player of the adaptive immune response are T cells, and recent studies argue for a major role …
View article: Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism
Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism Open
Adult stem cells are long-lived and quiescent with unique metabolic requirements. Macroautophagy/autophagy is a fundamental survival mechanism that allows cells to adapt to metabolic changes by degrading and recycling intracellular compone…
View article: Autophagy orchestrates the crosstalk between cells and organs
Autophagy orchestrates the crosstalk between cells and organs Open
Over the recent years, it has become apparent that a deeper understanding of cell‐to‐cell and organ‐to‐organ communication is necessary to fully comprehend both homeostatic and pathological states. Autophagy is indispensable for cellular d…
View article: The central role of DNA damage in immunosenescence
The central role of DNA damage in immunosenescence Open
Ageing is the biggest risk factor for the development of multiple chronic diseases as well as increased infection susceptibility and severity of diseases such as influenza and COVID-19. This increased disease risk is linked to changes in i…
View article: Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation
Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation Open
CD4+ T cells are pivotal cells playing roles in the orchestration of humoral and cytotoxic immune responses. It is known that CD4+ T cell proliferation relies on autophagy, but identification of the autophagosomal cargo involved is missing…
View article: GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans Open
Inborn errors of immunity (IEIs) unveil regulatory pathways of human immunity. We describe a new IEI caused by mutations in the GTPase of the immune-associated protein 6 (GIMAP6) gene in patients with infections, lymphoproliferation, autoi…
View article: Autophagy takes it all – autophagy inducers target immune aging
Autophagy takes it all – autophagy inducers target immune aging Open
Autophagy, as the key nutrient recycling pathway, enables eukaryotic cells to adapt to surging cellular stress during aging and, thereby, delays age-associated deterioration. Autophagic flux declines with age and, in turn, decreases in aut…
View article: B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice Open
The germinal center (GC) is a site where somatic hypermutation and clonal selection are coupled for antibody affinity maturation against infections. However, how GCs are formed and regulated is incompletely understood. Here, we identified …
View article: Mapping of the autophagosomal degradome identifies IL-7Rα as key cargo in proliferating CD4+ T-cells
Mapping of the autophagosomal degradome identifies IL-7Rα as key cargo in proliferating CD4+ T-cells Open
CD4+ T cells orchestrate both humoral and cytotoxic immune responses. While it is known that CD4+ T cell proliferation relies on autophagy, direct identification of the autophagosomal cargo involved is still missing. Here, we created a tra…
View article: Adipocyte autophagy limits gut inflammation by controlling oxylipin levels
Adipocyte autophagy limits gut inflammation by controlling oxylipin levels Open
Lipids play a major role in inflammatory diseases by altering inflammatory cell functions, through their use as energy substrates or as lipid mediators such as oxylipins. Autophagy, a lysosomal degradation pathway that limits inflammation,…
View article: Improving bone health via modulation of glycosphingolipid metabolism and autophagy
Improving bone health via modulation of glycosphingolipid metabolism and autophagy Open
Patients with multiple myeloma (MM), an incurable malignancy of plasma cells, frequently develop osteolytic bone lesions. In this study, glycosphingolipids were essential in promoting autophagic degradation of the signaling molecule TRAF3,…