Explanipedia

Lower, more frequent cisplatin dosing minimizes hearing loss in head and neck cancer Open

Katharine Fernandez, Abu Zaffar Chowdhury, Amanda Bonczkowski, Paul Allen, Maura Campbell , et al. · 2025

BACKGROUNDCisplatin is often the cytotoxic drug of choice for chemoradiation therapy (CRT) for head and neck squamous cell carcinoma (HNSCC), but it can lead to irreversible hearing loss. There may be similar oncologic outcomes but differe…

Effects of Cholesterol Modulation on Cisplatin-Induced Hearing Loss Open

John Lee, Marcello Peppi, Megan Guidry, Katharine Fernandez, Abu Zaffar Chowdhury , et al. · 2025

Cisplatin is a widely used and effective anticancer drug. However, it causes permanent sensorineural hearing loss in over 50% of treated patients. There are no FDA-approved therapies to prevent cisplatin-induced hearing loss (CIHL) in adul…

Effects of neoadjuvant immunotherapy on hearing in patients with head and neck squamous cell carcinoma Open

Bryce Hambach, Anhelina Bilokon, J. Jack Lee, L Noelle Allemang, Jennifer Chisholm , et al. · 2025

The Effects of Metformin on Cisplatin‐Induced Ototoxicity in Diabetic Patients Open

Marc‐Elie Nader, Jonathan S. Choi, Mike Hernández, Katherine A. Hutcheson, Taylor Myers , et al. · 2024

Objective Ototoxicity is an important side effect of cisplatin. Recent animal and in vitro studies suggest metformin may protect hearing, though human studies are lacking. We report the first retrospective clinical study exploring the effe…

Macrophage depletion protects against cisplatin-induced ototoxicity and nephrotoxicity Open

Cathy Yea Won Sung, Naoki Hayase, Peter S.T. Yuen, John Lee, Katharine Fernandez , et al. · 2024

Cisplatin is a widely used anticancer drug with notable side effects including ototoxicity and nephrotoxicity. Macrophages, the major resident immune cells in the cochlea and kidney, are important drivers of both inflammatory and tissue re…

Large-scale annotated dataset for cochlear hair cell detection and classification Open

Christopher J. Buswinka, David B. Rosenberg, Rubina G. Simikyan, Richard T. Osgood, Katharine Fernandez , et al. · 2024

Large-scale annotated dataset for cochlear hair cell detection and classification Open

Christopher J. Buswinka, David B. Rosenberg, Rubina G. Simikyan, Richard T. Osgood, Katharine Fernandez , et al. · 2024

Our sense of hearing is mediated by cochlear hair cells, of which there are two types organized in one row of inner hair cells and three rows of outer hair cells. Each cochlea contains 5 - 15 thousand terminally differentiated hair cells, …

Large-scale annotated dataset for cochlear hair cell detection and classification Open

Christopher J. Buswinka, David B. Rosenberg, Rubina G. Simikyan, Richard T. Osgood, Katharine Fernandez , et al. · 2024

Our sense of hearing is mediated by cochlear hair cells, of which there are two types organized in one row of inner hair cells and three rows of outer hair cells. Each cochlea contains 5 - 15 thousand terminally differentiated hair cells, …

Macrophage Depletion Protects Against Cisplatin-Induced Ototoxicity and Nephrotoxicity Open

Cathy Yea Won Sung, Naoki Hayase, Peter S.T. Yuen, John Lee, Katharine Fernandez , et al. · 2023

Cisplatin is a widely used and highly effective anti-cancer drug with significant side effects including ototoxicity and nephrotoxicity. Macrophages, the major resident immune cells in the cochlea and kidney, are important drivers of both …

EP06.03-08 Clinical Study to Molecularly Profile Filipino Lung Adenocarcinoma Open

Francisco M. Heralde, M. Cabanatan, Katharine Fernandez, Maria Perlita B. Apelado, N. Tan-Liu , et al. · 2023

Large-scale annotated dataset for cochlear hair cell detection and classification Open

Christopher J. Buswinka, David B. Rosenberg, Rubina G. Simikyan, Richard T. Osgood, Katharine Fernandez , et al. · 2023

Our sense of hearing is mediated by cochlear hair cells, of which there are two types organized in one row of inner hair cells and three rows of outer hair cells. Each cochlea contains 5 - 15 thousand terminally differentiated hair cells, …

Large-scale annotated dataset for cochlear hair cell detection and classification Open

Christopher J. Buswinka, David B. Rosenberg, Rubina G. Simikyan, Richard T. Osgood, Katharine Fernandez , et al. · 2023

This is the dataset behind the Hair Cell Analysis Toolbox (HCAT)

Large-scale annotated dataset for cochlear hair cell detection and classification Open

Christopher J. Buswinka, David B. Rosenberg, Rubina G. Simikyan, Richard T. Osgood, Katharine Fernandez , et al. · 2023

Our sense of hearing is mediated by cochlear hair cells, localized within the sensory epithelium called the organ of Corti. There are two types of hair cells in the cochlea, which are organized in one row of inner hair cells and three rows…

Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss Open

John Lee, Katharine Fernandez, Lisa L. Cunningham · 2023

Each year over half a million people experience permanent hearing loss caused by treatment with therapeutic drugs with ototoxic side effects. There is a major unmet clinical need for therapies that protect against this hearing loss without…

Combined AAV-mediated gene replacement therapy improves auditory function in a mouse model of human DFNB42 deafness Open

Kevin Isgrig, Alexander X. Cartagena‐Rivera, Hong Jun Wang, M’hamed Grati, Katharine Fernandez , et al. · 2023

Large-scale annotated dataset for cochlear hair cell detection and classification Open

Christopher J. Buswinka, David B. Rosenberg, Rubina G. Simikyan, Richard T. Osgood, Katharine Fernandez , et al. · 2023

This is the dataset behind the Hair Cell Analysis Toolbox (HCAT)

Single-Cell RNA-Seq of Cisplatin-Treated Adult Stria Vascularis Identifies Cell Type-Specific Regulatory Networks and Novel Therapeutic Gene Targets Open

Ian Taukulis, Rafal T. Olszewski, Soumya Korrapati, Katharine Fernandez, Erich T. Boger , et al. · 2021

The endocochlear potential (EP) generated by the stria vascularis (SV) is necessary for hair cell mechanotransduction in the mammalian cochlea. We sought to create a model of EP dysfunction for the purposes of transcriptional analysis and …

Atorvastatin is associated with reduced cisplatin-induced hearing loss Open

Katharine Fernandez, Paul Allen, Maura Campbell, B.R. Page, Thomas G. Townes , et al. · 2021

BACKGROUNDCisplatin is widely used to treat adult and pediatric cancers. It is the most ototoxic drug in clinical use, resulting in permanent hearing loss in approximately 50% of treated patients. There is a major need for therapies that p…

Trk agonist drugs rescue noise-induced hidden hearing loss Open

Katharine Fernandez, Takahisa Watabe, Mingjie Tong, Xiankai Meng, Kohsuke Tani , et al. · 2020

TrkB agonist drugs are shown here to have a significant effect on the regeneration of afferent cochlear synapses after noise-induced synaptopathy. The effects were consistent with regeneration of cochlear synapses that we observed in vitro…

Feasibility of Portable Audiometry for Ototoxicity Monitoring in a Radiation Oncology Clinic for Head and Neck Cancer Patients Receiving Cisplatin-Based Chemoradiotherapy Open

B.R. Page, Katharine Fernandez, J. Garrett, Marta Marcia, Aine Clements , et al. · 2020

Trk Agonist Drugs Rescue Noise-Induced Hidden Hearing Loss Open

Katharine Fernandez, Takahisa Watabe, Mingjie Tong, Xiankai Meng, Kohsuke Tani , et al. · 2020

TrkB agonist drugs are shown here to have a significant effect on the regeneration of afferent cochlear synapses after noise-induced synaptopathy. The effects were consistent with regeneration of cochlear synapses that we observed in vitro…

Ototoxicity and Platinum Uptake Following Cyclic Administration of Platinum-Based Chemotherapeutic Agents Open

Benjamin K. Gersten, Tracy S. Fitzgerald, Katharine Fernandez, Lisa L. Cunningham · 2020

Stability of Early Auditory Evoked Potential Components Over Extended Test-Retest Intervals in Young Adults Open

Rebecca E. Bieber, Katharine Fernandez, Chris Zalewski, Hui Cheng, Carmen C. Brewer · 2020

Objectives: Synaptic damage from noise exposures can occur even in the absence of changes in hearing sensitivity in animal models. There is an unmet clinical need for measurements sensitive to such damage to the human auditory system that …

Lovastatin protects against cisplatin-induced hearing loss in mice Open

Katharine Fernandez, Katie Spielbauer, Aaron E. Rusheen, Lizhen Wang, Tiffany Baker , et al. · 2020

Noise-induced Cochlear Synaptopathy with and Without Sensory Cell Loss Open

Katharine Fernandez, Dan Guo, Steven Micucci, Victor De Gruttola, M. Charles Liberman , et al. · 2019

Planned Observational Study of Hearing Loss and the Effects of Statin Drugs in Head and Neck Squamous Cell Carcinoma Patients Treated With Chemoradiation Open

Nicole C. Schmitt, Katharine Fernandez, B.R. Page, Lisa L. Cunningham · 2018

Cisplatin is retained in the cochlea indefinitely following chemotherapy Open

Andrew Breglio, Aaron E. Rusheen, Eric Shide, Katharine Fernandez, Katie Spielbauer , et al. · 2017

Aging after Noise Exposure: Acceleration of Cochlear Synaptopathy in “Recovered” Ears Open

Katharine Fernandez, Penelope W. C. Jeffers, Kumud Lall, M. Charles Liberman, Sharon G. Kujawa · 2015

Cochlear synaptic loss, rather than hair cell death, is the earliest sign of damage in both noise- and age-related hearing impairment (Kujawa and Liberman, 2009; Sergeyenko et al., 2013). Here, we compare cochlear aging after two types of …

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