Katherine C. Konvinse
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View article: Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection
Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection Open
Pediatric SARS-CoV-2 infection results in clinical presentations ranging from asymptomatic/mild infection to severe pulmonary COVID-19, to Multisystem Inflammatory Syndrome in Children (MIS-C), characterized by hyperinflammation and multi-…
View article: Single-cell immunopathology of recurrent acute generalized exanthematous pustulosis associated with vancomycin
Single-cell immunopathology of recurrent acute generalized exanthematous pustulosis associated with vancomycin Open
This patient exhibited persistent vancomycin-positive IDT despite distinct nondrug episodes of ALEP/AGEP. This suggests that AGEP may be triggered by both antigen-specific and non-antigen-specific factors. AGEP-affected skin showed an infl…
View article: Multiomic single-cell sequencing defines tissue-specific responses in Stevens-Johnson Syndrome and Toxic epidermal necrolysis.
Multiomic single-cell sequencing defines tissue-specific responses in Stevens-Johnson Syndrome and Toxic epidermal necrolysis. Open
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is a rare but life-threatening cutaneous drug reaction mediated by human leukocyte antigen (HLA) class I-restricted CD8+ T-cells. To obtain an unbiased assessment of SJS/TEN…
View article: Air pollution and pregnancy
Air pollution and pregnancy Open
View article: Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth
Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth Open
View article: High prevalence of autoantibodies in children after COVID-19 infection of differing levels of severity
High prevalence of autoantibodies in children after COVID-19 infection of differing levels of severity Open
View article: Systems biological assessment of the temporal dynamics of immunity to a viral infection in the first weeks and months of life
Systems biological assessment of the temporal dynamics of immunity to a viral infection in the first weeks and months of life Open
The dynamics of innate and adaptive immunity to infection in infants remain obscure. Here, we used a multi-omics approach to perform a longitudinal analysis of immunity to SARS-CoV-2 infection in infants and young children in the first wee…
View article: Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A∗32:01–positive vancomycin-induced DRESS sharing an HLA class II haplotype
Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A∗32:01–positive vancomycin-induced DRESS sharing an HLA class II haplotype Open
View article: Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding Immune-Mediated Adverse Drug Reactions
Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding Immune-Mediated Adverse Drug Reactions Open
Adverse drug reactions (ADRs) are a significant health care burden. Immune-mediated adverse drug reactions (IM-ADRs) are responsible for one-fifth of ADRs but contribute a disproportionately high amount of that burden due to their severity…
View article: Antibiotic Allergy in Pediatrics
Antibiotic Allergy in Pediatrics Open
The overlabeling of pediatric antibiotic allergy represents a huge burden in society. Given that up to 10% of the US population is labeled as penicillin allergic, it can be estimated that at least 5 million children in this country are lab…
View article: Single Cell Approaches to Define the Pathogenic Immune Cells that Mediate Drug Hypersensitivity
Single Cell Approaches to Define the Pathogenic Immune Cells that Mediate Drug Hypersensitivity Open
View article: The Combined Utility of Ex Vivo IFN-γ Release Enzyme-Linked ImmunoSpot Assay and In Vivo Skin Testing in Patients with Antibiotic-Associated Severe Cutaneous Adverse Reactions
The Combined Utility of Ex Vivo IFN-γ Release Enzyme-Linked ImmunoSpot Assay and In Vivo Skin Testing in Patients with Antibiotic-Associated Severe Cutaneous Adverse Reactions Open
View article: Severe Delayed Cutaneous and Systemic Reactions to Drugs: A Global Perspective on the Science and Art of Current Practice
Severe Delayed Cutaneous and Systemic Reactions to Drugs: A Global Perspective on the Science and Art of Current Practice Open
View article: Old dog begging for new tricks: current practices and future directions in the diagnosis of delayed antimicrobial hypersensitivity
Old dog begging for new tricks: current practices and future directions in the diagnosis of delayed antimicrobial hypersensitivity Open
Purpose of review Antimicrobials are a leading cause of severe T cell-mediated adverse drug reactions (ADRs). The purpose of this review is to address the current understanding of antimicrobial cross-reactivity and the ready availability o…
View article: Altered TGF‐α/β signaling drives cooperation between breast cancer cell populations
Altered TGF‐α/β signaling drives cooperation between breast cancer cell populations Open
The role of tumor heterogeneity in regulating disease progression is poorly understood. We hypothesized that interactions between subpopulations of cancer cells can affect the progression of tumors selecting for a more aggressive phenotype…
View article: Characterization of TCR repertoire diversity and tissue distribution of drug-specific T cells in DRESS
Characterization of TCR repertoire diversity and tissue distribution of drug-specific T cells in DRESS Open
View article: Single cell analysis of drug responsive T cells; identification of candidate drug reactive T cell receptors in abacavir and carbamazepine hypersensitivity
Single cell analysis of drug responsive T cells; identification of candidate drug reactive T cell receptors in abacavir and carbamazepine hypersensitivity Open