Explanipedia

Rvd2 Limits Senescent Cell Accumulation in Atherosclerotic Plaques Open

Masharh Lipscomb, Ignacia Antonia Salfate del Rio, M. Abu Eid, Allison Rahtes, Sudeshna Sadhu , et al. · 2025

Impact of E. muris infection on B. burgdorferi–induced joint pathology in mice Open

Jesse L. Bonin, Steven R. Torres, Ashley L. Marcinkiewicz, G Duhamel, Xiuli Yang , et al. · 2024

Tick-borne infections are increasing in the United States and around the world. The most common tick-borne disease in the United States is Lyme disease caused by infection with the spirochete Borrelia burgdorferi ( Bb ), and pathogenesis v…

Resolvin E1 improves efferocytosis and rescues severe aplastic anemia in mice Open

Rachel Grazda, Allison Seyfried, Krishna Rao Maddipati, Gabrielle Fredman, Katherine C. MacNamara · 2024

Survivors of polymicrobial sepsis are refractory to G-CSF-induced emergency myelopoiesis and hematopoietic stem and progenitor cell mobilization Open

Nirupam Biswas, Amber Bahr, Jennifer Howard, Jesse L. Bonin, Rachel Grazda , et al. · 2024

Resolvin D2–G-Protein Coupled Receptor 18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging Open

Hannah K. Fitzgerald, Jesse L. Bonin, Sayeed Khan, M. Abu Eid, Sudeshna Sadhu , et al. · 2023

Resolvin E1 improves efferocytosis and rescues severe aplastic anemia in mice Open

Rachel Grazda, Allison Seyfried, Krishna Rao Maddipatti, Gabrielle Fredman, Katherine C. MacNamara · 2023

Current treatments for severe aplastic anemia (SAA) rely on hematopoietic stem cell (HSC) transplantation and immunosuppressive therapies, however these treatments are not always effective. While immune-mediated destruction and inflammatio…

The Resolvin D2-GPR18 Axis Enhances Bone Marrow Function and Limits Hepatic Fibrosis in Aging Open

Hannah K. Fitzgerald, Jesse L. Bonin, Sudeshna Sadhu, Masharh Lipscomb, Nirupam Biswas , et al. · 2023

Aging is associated with non-resolving inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a pro-resolving ligand that acts through the G-protein coupled receptor (GPCR) called GRP18. Using an unbiased screen, we report increased Gp…

The effect of morphine on rat microglial phagocytic activity: an in vitro study of brain region-, plating density-, sex-, morphine concentration-, and receptor-dependency Open

David N. King’uyu, Lily Nti-Kyemereh, Jesse L. Bonin, Paul J. Feustel, Michelle Tram , et al. · 2022

Opioids have long been used for clinical pain management, but also have addictive properties that have contributed to the ongoing opioid epidemic. While opioid activation of opioid receptors is well known to contribute to reward and reinfo…

Co-infection of Ehrlichia with <i>B. burgdorferi</i> drives emergency myelopoiesis and promotes Lyme arthritis Open

Jesse L. Bonin, Steven R. Torres, Ashley L. Marcinkiewicz, Xiuli Yang, Utpal Pal , et al. · 2022

Lyme disease is caused by the extracellular pathogen Borrelia burgdorferi ( Bb ), transmitted by the Ixodes scapularis tick. Approximately one-third of infected individuals develop arthritis of weight-bearing joints, though it is unclear w…

Code Red in the Supply Center: The Impact of Immune Activation on Hematopoiesis Open

Katherine C. MacNamara, Martijn A. Nolte · 2022

This Special Issue entitled “The Impact of Immune Activation on Hematopoiesis” aims to bring together review and primary articles focused on distinct types of immune activation that impact hematopoiesis [...]

Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen Open

Marieke Goedhart, Edith Slot, María Fernanda Pascutti, Sulima Geerman, Timo Rademakers , et al. · 2021

Apart from controlling hematopoiesis, the bone marrow (BM) also serves as a secondary lymphoid organ, as it can induce naïve T cell priming by resident dendritic cells (DC). When analyzing DCs in murine BM, we uncovered that they are local…

IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock Open

Jennifer Howard, Julianne Smith, Gabrielle Fredman, Katherine C. MacNamara · 2021

Atherosclerosis is a major human killer and non-resolving inflammation is a prime suspect Open

Gabrielle Fredman, Katherine C. MacNamara · 2021

The resolution of inflammation (or inflammation-resolution) is an active and highly coordinated process. Inflammation-resolution is governed by several endogenous factors, and specialized pro-resolving mediators (SPMs) are one such class o…

Radiation-Induced Macrophage Senescence Impairs Resolution Programs and Drives Cardiovascular Inflammation Open

Sudeshna Sadhu, Christa Decker, Brian E. Sansbury, Michael Marinello, Allison Seyfried , et al. · 2021

Radiation is associated with tissue damage and increased risk of atherosclerosis, but there are currently no treatments and a very limited mechanistic understanding of how radiation impacts tissue repair mechanisms. We uncovered that radia…

Sub-lethal radiation-induced senescence impairs resolution programs and drives cardiovascular inflammation Open

Sudeshna Sadhu, Christa Decker, Brian E. Sansbury, Michael Marinello, Allison Seyfried , et al. · 2021

Radiation is associated with tissue damage and increased risk of atherosclerosis but there are currently no treatments and a very limited mechanistic understanding of how radiation impacts tissue repair mechanisms. We uncovered that radiat…

CCR5 maintains macrophages in the bone marrow and drives hematopoietic failure in a mouse model of severe aplastic anemia Open

Allison Seyfried, Amanda F. McCabe, Julianne Smith, Laura M. Calvi, Katherine C. MacNamara · 2021

Decision letter: Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics Open

Katherine C. MacNamara · 2021

Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Innate immune cell…

Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress Open

Allison Seyfried, Jackson Maloney, Katherine C. MacNamara · 2020

The bone marrow contains distinct cell types that work in coordination to generate blood and immune cells, and it is the primary residence of hematopoietic stem cells (HSCs) and more committed multipotent progenitors (MPPs). Even at homeos…

Resolvin D1 promotes efferocytosis in aging by limiting senescent cell‐induced MerTK cleavage Open

Nicholas Rymut, Justin Heinz, Sudeshna Sadhu, Zeinab Hosseini, Colin O. Riley , et al. · 2019

Inflammation‐resolution is mediated by the balance between specialized pro‐resolving mediators (SPMs) like resolvin D1 (RvD1) and pro‐inflammatory factors, like leukotriene B 4 (LTB 4 ). A key cellular process of inflammation‐resolution is…

Aged marrow macrophages expand platelet-biased hematopoietic stem cells via interleukin-1B Open

Benjamin J. Frisch, Corey M. Hoffman, Sarah E. Latchney, Mark W. LaMere, Jason R. Myers , et al. · 2019

The bone marrow microenvironment (BMME) contributes to the regulation of hematopoietic stem cell (HSC) function, though its role in age-associated lineage skewing is poorly understood. Here we show that dysfunction of aged marrow macrophag…

Type I IFNs drive hematopoietic stem and progenitor cell collapse via impaired proliferation and increased RIPK1-dependent cell death during shock-like ehrlichial infection Open

Julianne Smith, Yubin Zhang, Jing Jing Li, Amanda F. McCabe, Hui Jin Jo , et al. · 2018

Type I interferons (IFNα/β) regulate diverse aspects of host defense, but their impact on hematopoietic stem and progenitor cells (HSC/HSPCs) during infection remains unclear. Hematologic impairment can occur in severe infections, thus we …

Hematopoietic stem cell loss and hematopoietic failure in severe aplastic anemia is driven by macrophages and aberrant podoplanin expression Open

Amanda F. McCabe, Julianne Smith, Angelica Costello, Jackson Maloney, Divya S. Katikaneni , et al. · 2018

Severe aplastic anemia (SAA) results from profound hematopoietic stem cell loss. T cells and interferon gamma (IFNγ) have long been associated with SAA, yet the underlying mechanisms driving hematopoietic stem cell loss remain unknown. Usi…

Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells Open

Kangning Zhang, Xingyuan Xu, Muhammad Asghar Pasha, Christian W. Siebel, Angelica Costello , et al. · 2017

The mechanisms underlying lymphocyte lineage stability and plasticity remain elusive. Recent work indicates that innate lymphoid cells (ILC) possess substantial plasticity. Whereas natural ILC2 (nILC2) produce type-2 cytokines, plastic inf…

Hematopoietic Stem Cell Regulation by Type I and II Interferons in the Pathogenesis of Acquired Aplastic Anemia Open

Julianne Smith, Vikramjit S. Kanwar, Katherine C. MacNamara · 2016

Aplastic anemia (AA) occurs when the bone marrow fails to support production of all three lineages of blood cells, which are necessary for tissue oxygenation, infection control, and hemostasis. The etiology of acquired AA is elusive in the…

Shedding light on HSC dormancy—a role for the DARC Open

Katherine C. MacNamara · 2016

Hematopoietic stem cell (HSC) quiescence is vital for lifelong hematopoiesis as it maintains long-term potential and self-renewal capacity of HSCs. Hypoxia is one feature of the bone marrow (BM) microenvironment thought to contribute to qu…

An Immature Myeloid/Myeloid-Suppressor Cell Response Associated with Necrotizing Inflammation Mediates Lethal Pulmonary Tularemia Open

Sivakumar Periasamy, Dorina Avram, Amanda F. McCabe, Katherine C. MacNamara, Timothy J. Sellati , et al. · 2016

Inhalation of Francisella tularensis (Ft) causes acute and fatal pneumonia. The lung cytokine milieu favors exponential Ft replication, but the mechanisms underlying acute pathogenesis and death remain unknown. Evaluation of the sequential…

Macrophages: Key regulators of steady-state and demand-adapted hematopoiesis Open

Amanda F. McCabe, Katherine C. MacNamara · 2016

Macrophage-Lineage Cells Negatively Regulate the Hematopoietic Stem Cell Pool in Response to Interferon Gamma at Steady State and During Infection Open

Amanda F. McCabe, Yubin Zhang, Vinh Thai, Maura Jones, Michael B. Jordan , et al. · 2015

Bone marrow (BM) resident macrophages (Mϕs) regulate hematopoietic stem cell (HSC) mobilization; however, their impact on HSC function has not been investigated. We demonstrate that depletion of BM resident Mϕs increases HSC proliferation …

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