Katherine C. Woronowicz
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View article: Phylogenomic analysis of the Lake Kronotskoe species flock of Dolly Varden charr reveals genetic and developmental signatures of sympatric radiation
Phylogenomic analysis of the Lake Kronotskoe species flock of Dolly Varden charr reveals genetic and developmental signatures of sympatric radiation Open
Recent adaptive radiations provide experimental opportunities to parse the relationship between genomic variation and the origins of distinct phenotypes. Sympatric radiations of the charr complex (genus Salvelinus) present a trove for phyl…
View article: Phylogenomic analysis of the Lake Kronotskoe species flock of Dolly Varden charr reveals genetic and developmental signatures of sympatric radiation
Phylogenomic analysis of the Lake Kronotskoe species flock of Dolly Varden charr reveals genetic and developmental signatures of sympatric radiation Open
Recent adaptive radiations provide evolutionary case studies, which provide the context to parse the relationship between genomic variation and the origins of distinct phenotypes. Sympatric radiations of the charr complex (genus Salvelinus…
View article: Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation
Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation Open
Low-density Lipoprotein Receptor-related Protein 5 ( LRP5 ) functions as a co-receptor for Wnt ligands, controlling expression of genes involved in osteogenesis. In humans, loss-of-function mutations in LRP5 cause Osteoporosis-Pseudoglioma…
View article: Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development
Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development Open
Wnt signaling plays a critical role in craniofacial patterning, as well as tooth and bone development. Rspo2 and Rspo3 are key regulators of Wnt signaling. However, their coordinated function and relative requirement in craniofacial develo…
View article: Abstract QS5: Requirement Of Wnt Modulator R-spondin3 In Craniofacial Morphogenesis, Dental Development And Bone Homeostasis
Abstract QS5: Requirement Of Wnt Modulator R-spondin3 In Craniofacial Morphogenesis, Dental Development And Bone Homeostasis Open
Purpose: Investigating the expression and function of Wnt modulator rspo3 in craniofacial development will improve our molecular understanding of craniofacial development. Methods: Using ChIPseq and RNAseq, we identified rspo3 as an irf6 t…
View article: Molecular and cellular mechanisms underlying the evolution of form and function in the amniote jaw
Molecular and cellular mechanisms underlying the evolution of form and function in the amniote jaw Open
The amniote jaw complex is a remarkable amalgamation of derivatives from distinct embryonic cell lineages. During development, the cells in these lineages experience concerted movements, migrations, and signaling interactions that take the…
View article: FGF and TGFβ signaling link form and function during jaw development and evolution
FGF and TGFβ signaling link form and function during jaw development and evolution Open
How does form arise during development and change during evolution? How does form relate to function, and what enables embryonic structures to presage their later use in adults? To address these questions, we leverage the distinct function…
View article: Developmental Mechanisms Linking Form and Function During Jaw Evolution
Developmental Mechanisms Linking Form and Function During Jaw Evolution Open
How does form arise during development and change during evolution? How does form relate to function, and what enables embryonic structures to presage their later use in adults? To address these questions, we leverage the distinct function…
View article: Signaling Mechanisms Involved in the Induction and Maintenance of Secondary Cartilage on the Coronoid Process of the Mandible
Signaling Mechanisms Involved in the Induction and Maintenance of Secondary Cartilage on the Coronoid Process of the Mandible Open
How does form arise during development and change during evolution? How does form relate to function, and what enables structures of embryos to presage their later use in adults? To address these questions, we leverage the distinct functio…