Katherine G. Birmingham
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View article: Adhesion strength of tumor cells predicts metastatic disease in vivo
Adhesion strength of tumor cells predicts metastatic disease in vivo Open
Although only a fraction of tumor cells contribute to metastatic disease, no prognostic biomarkers currently exist to identify these cells. We show that a physical marker-adhesion strength-predicts metastatic potential in a mouse breast ca…
View article: Stromal Cell Adhesion Predicts Severity of Metastatic Disease
Stromal Cell Adhesion Predicts Severity of Metastatic Disease Open
Despite better outcomes with early-stage detection, local invasion significantly reduces patient survival rates for many carcinomas. Heterogeneity within and between tumors has precluded identification of predictive biological markers, but…
View article: Computational models of migration modes improve our understanding of metastasis
Computational models of migration modes improve our understanding of metastasis Open
Tumor cells migrate through changing microenvironments of diseased and healthy tissue, making their migration particularly challenging to describe. To better understand this process, computational models have been developed for both the am…
View article: Lymph Node Subcapsular Sinus Microenvironment-On-A-Chip Modeling Shear Flow Relevant to Lymphatic Metastasis and Immune Cell Homing
Lymph Node Subcapsular Sinus Microenvironment-On-A-Chip Modeling Shear Flow Relevant to Lymphatic Metastasis and Immune Cell Homing Open
A lymph node sinus-on-a-chip adhesion microfluidic platform that recapitulates the hydrodynamic microenvironment of the lymph node subcapsular sinus was engineered. This device was used to interrogate the effects of lymph node remodeling o…
View article: Photoconversion and chromatographic microfluidic system reveals differential cellular phenotypes of adhesion velocity <i>versus</i> persistence in shear flow
Photoconversion and chromatographic microfluidic system reveals differential cellular phenotypes of adhesion velocity <i>versus</i> persistence in shear flow Open
Engineered cell sorting, photoconversion platform to interrogate mechanisms of metastatic cancer cell dissemination.
View article: Analyzing Mechanisms of Metastatic Cancer Cell Adhesive Phenotype Leveraging Preparative Adhesion Chromatography Microfluidic
Analyzing Mechanisms of Metastatic Cancer Cell Adhesive Phenotype Leveraging Preparative Adhesion Chromatography Microfluidic Open
An integrated, parallel‐plate microfluidic device is engineered to interrogate and fractionate cells based on their adhesivity to a substrate surface functionalized with adhesive ligand in a tightly controlled flow environment to elucidate…