Katherine Gurdziel
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View article: EXTH-143. Preclinical Efficacy of Brain Penetrant, Single Agent Avapritinib in <i>PDGFRA</i> EcDNA-amplified Glioblastoma
EXTH-143. Preclinical Efficacy of Brain Penetrant, Single Agent Avapritinib in <i>PDGFRA</i> EcDNA-amplified Glioblastoma Open
The high prevalence of platelet derived growth factor receptor alpha (PDGFRA) alterations and its mitogenic function in oligodendrocyte precursor cells (OPC) make PDGFRA a promising therapeutic target in adult glioblastoma (GBM). Towards v…
View article: Genomic Surveillance for SARS-CoV-2 During the COVID-19 Pandemic: Collaborative Experience at Southeast Michigan
Genomic Surveillance for SARS-CoV-2 During the COVID-19 Pandemic: Collaborative Experience at Southeast Michigan Open
Regional genomic surveillance is essential for tracking viral evolution and informing targeted public health responses. During the COVID-19 pandemic, we established a collaborative genomic surveillance pipeline for SARS-CoV-2 in Southeast …
View article: Canagliflozin Reprograms the Aging Hippocampus in Genetically Diverse <scp>UM</scp>‐<scp>HET</scp>3 Mice and Attenuates Alzheimer's‐Like Pathology
Canagliflozin Reprograms the Aging Hippocampus in Genetically Diverse <span>UM</span>‐<span>HET</span>3 Mice and Attenuates Alzheimer's‐Like Pathology Open
Aging is the strongest risk factor for cognitive decline and Alzheimer's disease (AD), yet the mechanisms underlying brain aging and their modulation by pharmacological interventions remain poorly defined. The hippocampus, essential for le…
View article: Single-Cell Comparison of Schwann and Fibroblast Cells Reveals Distinct Transcriptional Programs in NF1-Associated Neurofibromas
Single-Cell Comparison of Schwann and Fibroblast Cells Reveals Distinct Transcriptional Programs in NF1-Associated Neurofibromas Open
Neurofibromatosis type 1 (NF1) is an inherited tumor predisposition syndrome characterized by the development of benign peripheral nerve sheath tumors, most commonly cutaneous neurofibromas (cNFs) and plexiform neurofibromas (pNFs). Althou…
View article: Correction: The miR-183/96/182 cluster regulates sensory innervation, resident myeloid cells and functions of the cornea through cell type-specific target genes
Correction: The miR-183/96/182 cluster regulates sensory innervation, resident myeloid cells and functions of the cornea through cell type-specific target genes Open
View article: Inter-Relationship Between Melanoma Vemurafenib Tolerance Thresholds and Metabolic Pathway Choice
Inter-Relationship Between Melanoma Vemurafenib Tolerance Thresholds and Metabolic Pathway Choice Open
Melanomas quickly acquire resistance to vemurafenib, an important therapeutic for BRAFV600 mutant melanomas. Although combating vemurafenib resistance (VemR) to counter mitochondrial metabolic shift using mitochondria-targeting therapies h…
View article: Canagliflozin reprograms the aging hippocampus in genetically diverse UM-HET3 mice and attenuates Alzheimer’s-like pathology
Canagliflozin reprograms the aging hippocampus in genetically diverse UM-HET3 mice and attenuates Alzheimer’s-like pathology Open
Aging is the strongest risk factor for cognitive decline and Alzheimer’s disease (AD), yet the mechanisms underlying brain aging and their modulation by pharmacological interventions remain poorly defined. The hippocampus, essential for le…
View article: Relationship between melanoma vemurafenib tolerance thresholds and metabolic pathway choice and Wnt signaling involvement
Relationship between melanoma vemurafenib tolerance thresholds and metabolic pathway choice and Wnt signaling involvement Open
Vemurafenib constitutes an important therapeutic for BRAFV600 mutant melanomas, but despite high initial response rates, resistance to BRAF and MEK inhibitors quickly develops. Here, we performed an integrative analysis of metabolomic cons…
View article: Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment
Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment Open
Glioblastoma (GBM) tumors exhibit extensive genomic, epigenomic, and transcriptional diversity, with significant intratumoral heterogeneity, complicating standard treatment approaches involving radiation (RT) and the DNA-alkylating agent t…
View article: Exposure of Ldlr−/− Mice to a PFAS Mixture and Outcomes Related to Circulating Lipids, Bile Acid Excretion, and the Intestinal Transporter ASBT
Exposure of Ldlr−/− Mice to a PFAS Mixture and Outcomes Related to Circulating Lipids, Bile Acid Excretion, and the Intestinal Transporter ASBT Open
Mice exposed to a PFAS mixture displayed higher circulating cholesterol and bile acids perhaps due to impacts on enterohepatic circulation. This study implicates PFAS-mediated effects at the site of the ileum as a possible critical mediato…
View article: siRNA that participates in <i>Drosophila</i> dosage compensation is produced by many 1.688X and 359 bp repeats
siRNA that participates in <i>Drosophila</i> dosage compensation is produced by many 1.688X and 359 bp repeats Open
Organisms with differentiated sex chromosomes must accommodate unequal gene dosage in males and females. Male fruit flies increase X-linked gene expression to compensate for hemizygosity of their single X chromosome. Full compensation requ…
View article: The miR-183/96/182 cluster regulates sensory innervation, resident myeloid cells and functions of the cornea through cell type-specific target genes
The miR-183/96/182 cluster regulates sensory innervation, resident myeloid cells and functions of the cornea through cell type-specific target genes Open
View article: Impact of genomic background and developmental state on signaling pathways and response to therapy in glioblastoma patient-derived cells
Impact of genomic background and developmental state on signaling pathways and response to therapy in glioblastoma patient-derived cells Open
Glioblastoma (GBM) tumors represents diverse genomic epigenomic, and transcriptional landscapes, with significant intratumoral heterogeneity that challenges standard of care treatments involving radiation (RT) and the DNA-alkylating agent …
View article: Mixtures of per- and polyfluoroalkyl substances (PFAS) alter sperm methylation and long-term reprogramming of offspring liver and fat transcriptome
Mixtures of per- and polyfluoroalkyl substances (PFAS) alter sperm methylation and long-term reprogramming of offspring liver and fat transcriptome Open
Male fertility has been declining worldwide especially in countries with high levels of endocrine disrupting chemicals (EDCs). Per- and polyfluorinated alkyl Substances (PFAS) have been classified as EDCs and have been linked to adverse ma…
View article: The miR-183/96/182 cluster regulates sensory innervation, resident myeloid cells and functions of the cornea through cell-type-specfic target genes
The miR-183/96/182 cluster regulates sensory innervation, resident myeloid cells and functions of the cornea through cell-type-specfic target genes Open
The conserved miR-183/96/182 cluster (miR-183C) is expressed in both corneal resident myeloid cells (CRMCs) and sensory nerves (CSN) and modulates corneal immune/inflammatory responses. To uncover cell type-specific roles of miR-183C in CR…
View article: 2299. Genomic Epidemiology of <i>SARS-CoV-2</i> in Metropolitan Detroit
2299. Genomic Epidemiology of <i>SARS-CoV-2</i> in Metropolitan Detroit Open
Background The COVID-19 pandemic, resulting from the rapidly evolving SARS-CoV-2 virus, has drastically impacted health systems and economies worldwide. Genomic sequencing is critical for the surveillance of SARS-CoV-2 to monitor the rapid…
View article: A comparative analysis of gene and protein expression in chronic and acute models of photoreceptor degeneration in adult zebrafish
A comparative analysis of gene and protein expression in chronic and acute models of photoreceptor degeneration in adult zebrafish Open
Background: Adult zebrafish are capable of photoreceptor (PR) regeneration following acute phototoxic lesion (AL). We developed a chronic low light (CLL) exposure model that more accurately reflects chronic PR degeneration observed in many…
View article: The miR-183/96/182 cluster is a checkpoint for resident immune cells and shapes the cellular landscape of the cornea
The miR-183/96/182 cluster is a checkpoint for resident immune cells and shapes the cellular landscape of the cornea Open
View article: Global Run-On sequencing to measure nascent transcription in Saccharomyces cerevisiae
Global Run-On sequencing to measure nascent transcription in Saccharomyces cerevisiae Open
View article: Genetic relatedness among <i>Neisseria gonorrhoeae</i> isolates in southeastern Michigan
Genetic relatedness among <i>Neisseria gonorrhoeae</i> isolates in southeastern Michigan Open
Background: Antimicrobial resistance (AMR) in Neisseria gonorrhoeae (NG) is an emerging public health crisis. Whole-genome sequencing (WGS) is an efficient way of predicting AMR determinants and their spread in the population. In a previou…
View article: Vascular cell-adhesion molecule 1 (VCAM-1) regulates JunB-mediated IL-8/CXCL1 expression and pathological neovascularization
Vascular cell-adhesion molecule 1 (VCAM-1) regulates JunB-mediated IL-8/CXCL1 expression and pathological neovascularization Open
View article: The role of the immune response and inflammatory pathways in TNF-related apoptosis-inducing ligand (TRAIL) resistance in triple-negative breast cancer cells.
The role of the immune response and inflammatory pathways in TNF-related apoptosis-inducing ligand (TRAIL) resistance in triple-negative breast cancer cells. Open
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer, and the majority of TNBC lacks targeted therapies. Previous studies have shown that TNBC cells are highly sensitive to TNF-related apoptosis-inducing ligand (TRAI…
View article: 325. Molecular Characterization of Antimicrobial Resistance Genes in <i>Neisseria gonorrhoeae</i> in Southeast Michigan
325. Molecular Characterization of Antimicrobial Resistance Genes in <i>Neisseria gonorrhoeae</i> in Southeast Michigan Open
Background Antimicrobial resistance (AMR) in Neisseria gonorrhoeae (NG) is a public health crisis. Diagnosis of infection is primarily established using nucleic acid amplification technologies (NAATs) without susceptibility testing; thus r…
View article: Insight into 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced disruption of zebrafish spermatogenesis via single cell RNA-seq
Insight into 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced disruption of zebrafish spermatogenesis via single cell RNA-seq Open
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent and environmentally persistent endocrine disrupting chemical. Our previous work demonstrated the latent reproductive maladies of early-life TCDD exposure in zebrafish. Zebrafish acutel…
View article: Comparative Toxicotranscriptomics of Single Cell RNA-Seq and Conventional RNA-Seq in TCDD-Exposed Testicular Tissue
Comparative Toxicotranscriptomics of Single Cell RNA-Seq and Conventional RNA-Seq in TCDD-Exposed Testicular Tissue Open
In this report, we compare the outcomes and limitations of two methods of transcriptomic inquiry on adult zebrafish testes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during sexual differentiation: conventional or bulk RNA-seq (b…
View article: A Comparative Analysis of Gene and Protein Expression Throughout a Full 28-Day Retinal Regeneration Time-Course in Adult Zebrafish
A Comparative Analysis of Gene and Protein Expression Throughout a Full 28-Day Retinal Regeneration Time-Course in Adult Zebrafish Open
Following photoreceptors ablation by intense light exposure, adult zebrafish are capable of complete regeneration due to the ability of their Müller glia (MG) to re-enter the cell cycle, creating progenitors that differentiate into new pho…
View article: Molecular diet studies of water mites reveal prey biodiversity
Molecular diet studies of water mites reveal prey biodiversity Open
Water mites are diverse aquatic invertebrates that provide potentially important ecosystem and economic services as bioindicators and mosquito biocontrol; however, little is known about water mite digestive physiology, including their diet…
View article: Analysis of Adaptive Olaparib Resistance Effects on Cisplatin Sensitivity in Triple Negative Breast Cancer Cells
Analysis of Adaptive Olaparib Resistance Effects on Cisplatin Sensitivity in Triple Negative Breast Cancer Cells Open
Poly-(ADP)-ribose polymerase inhibitors (PARPi) and platinum-based drugs are promising therapies for triple negative breast cancers (TNBC) with BRCA1 or BRCA2 loss. PARPi(s) show better efficacies when combined with platinum-based therapy,…
View article: Stress Decreases Host Viral Resistance and Increases Covid Susceptibility in Embryonic Stem Cells
Stress Decreases Host Viral Resistance and Increases Covid Susceptibility in Embryonic Stem Cells Open
View article: A comparative analysis of gene and protein expression during retinal regeneration in adult zebrafish using 3’mRNA sequencing and quantitative immunohistochemistry
A comparative analysis of gene and protein expression during retinal regeneration in adult zebrafish using 3’mRNA sequencing and quantitative immunohistochemistry Open