Katherine Hackett
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View article: Non‐Immersive Virtual Reality Assessment of Functional Abilities in Older Adults is Less Influenced by Demographic Features than Traditional Cognitive Test Scores
Non‐Immersive Virtual Reality Assessment of Functional Abilities in Older Adults is Less Influenced by Demographic Features than Traditional Cognitive Test Scores Open
Background Cognitive tests are crucial for clinical assessment of dementia, but are biased by education, sex, and race. We examined bias in a new measure of everyday cognition called the Virtual Kitchen Challenge (VKC), which requires part…
View article: Non‐Immersive Virtual Reality Assessment of Functional Abilities in Older Adults is Less Influenced by Demographic Features than Traditional Cognitive Test Scores
Non‐Immersive Virtual Reality Assessment of Functional Abilities in Older Adults is Less Influenced by Demographic Features than Traditional Cognitive Test Scores Open
Background Cognitive tests are crucial for clinical assessment of dementia, but are biased by education, sex, and race. We examined bias in a new measure of everyday cognition called the Virtual Kitchen Challenge (VKC), which requires part…
View article: Barriers and facilitators to usability of a smartphone-based digital mental health tool in older adults: Insights from a secondary analysis of mindLAMP
Barriers and facilitators to usability of a smartphone-based digital mental health tool in older adults: Insights from a secondary analysis of mindLAMP Open
These findings suggest that with modest training, older adults can engage with digital health tools and report positive usability experiences. Differences in usability outcomes by sex, race, and education point to potential characteristics…
View article: Demographic Predictors of Older Adults’ Performance on a Novel Virtual Reality–Based Everyday Function Test and Conventional Measures of Cognition and Function
Demographic Predictors of Older Adults’ Performance on a Novel Virtual Reality–Based Everyday Function Test and Conventional Measures of Cognition and Function Open
Objective: In contrast to conventional cognitive tests and questionnaires on everyday function, performance-based tests of everyday function typically show little to no relation to race, education, and other demographic variables. This stu…
View article: Older Adults Show Altered Network Connectivity during Fairness Decisions with Similar and Dissimilar Partners
Older Adults Show Altered Network Connectivity during Fairness Decisions with Similar and Dissimilar Partners Open
Objectives The ability to navigate diverse social contexts, such as interacting with different individuals, is crucial across the lifespan and has implications for fraud susceptibility. However, the neural mechanisms supporting social deci…
View article: The Virtual Kitchen Challenge–Version 2: Validation of a Digital Assessment of Everyday Function in Older Adults
The Virtual Kitchen Challenge–Version 2: Validation of a Digital Assessment of Everyday Function in Older Adults Open
Background Conventional methods of functional assessment include subjective self/informant-report, which may be biased by personal characteristics, cognitive abilities, and lack of standardization (e.g., influenced by idiosyncratic task de…
View article: Psychological, social, and health-related factors predict risk for financial exploitation
Psychological, social, and health-related factors predict risk for financial exploitation Open
People lose tens of billions of dollars a year to financial exploitation in the United States alone. Few studies have examined how preferences for trust and fairness in economic activities may contribute to risk for financial exploitation.…
View article: Psychological, social, and health-related factors predict risk for financial exploitation
Psychological, social, and health-related factors predict risk for financial exploitation Open
People lose tens of billions of dollars a year to financial exploitation in the United States alone. Few studies have examined how preferences for trust and fairness in economic activities may contribute to risk for financial exploitation.…
View article: Psychological, social, and health-related factors predict risk for financial exploitation
Psychological, social, and health-related factors predict risk for financial exploitation Open
People lose tens of billions of dollars a year to financial exploitation in the United States alone. Few studies have examined how preferences for trust and fairness in economic activities may contribute to risk for financial exploitation.…
View article: Exploring the differential impact of sociodemographic and extrinsic factors on mobility‐based digital phenotypes versus standard cognitive tests among older adults
Exploring the differential impact of sociodemographic and extrinsic factors on mobility‐based digital phenotypes versus standard cognitive tests among older adults Open
Background Passively‐obtained smartphone digital phenotypes may yield objective estimates of everyday cognition in older adults compared to traditional cognitive/self‐report measures typically confounded by sociodemographics. However, it i…
View article: Comparing the utility of mean versus intraindividual variability metrics in the relationship between mobility‐based digital phenotypes and cognition
Comparing the utility of mean versus intraindividual variability metrics in the relationship between mobility‐based digital phenotypes and cognition Open
Background Intraindividual variability (IIV) on neuropsychological task performance has demonstrated enhanced sensitivity to neuropathological decline compared to mean performance. It is currently unknown whether increased IIV in everyday …
View article: MODERATING EFFECT OF DEPRESSION ON THE ASSOCIATION OF COGNITIVE IMPAIRMENT WITH EVERYDAY FUNCTION IN OLDER ADULTS
MODERATING EFFECT OF DEPRESSION ON THE ASSOCIATION OF COGNITIVE IMPAIRMENT WITH EVERYDAY FUNCTION IN OLDER ADULTS Open
Cognitive impairment (CI) and depression often co-occur, and each is known to impair older adults’ ability to perform activities of daily living. We sought to determine whether co-morbid depression moderates the association of CI with impa…
View article: Feasibility, validity, and normative data for the remote Uniform Data Set neuropsychological battery at the University of Pennsylvania Alzheimer's Disease Research Center
Feasibility, validity, and normative data for the remote Uniform Data Set neuropsychological battery at the University of Pennsylvania Alzheimer's Disease Research Center Open
INTRODUCTION We investigated the feasibility and validity of the remotely‐administered neuropsychological battery from the National Alzheimer's Coordinating Center Uniform Data Set (UDS T‐Cog). METHODS Two hundred twenty Penn Alzheimer's D…
View article: Mobility-Based Smartphone Digital Phenotypes for Unobtrusively Capturing Everyday Cognition, Mood, and Community Life-Space in Older Adults: Feasibility, Acceptability, and Preliminary Validity Study
Mobility-Based Smartphone Digital Phenotypes for Unobtrusively Capturing Everyday Cognition, Mood, and Community Life-Space in Older Adults: Feasibility, Acceptability, and Preliminary Validity Study Open
Background Current methods of monitoring cognition in older adults are insufficient to address the growing burden of Alzheimer disease and related dementias (AD/ADRD). New approaches that are sensitive, scalable, objective, and reflective …
View article: Mobility-Based Smartphone Digital Phenotypes for Unobtrusively Capturing Everyday Cognition, Mood, and Community Life-Space in Older Adults: Feasibility, Acceptability, and Preliminary Validity Study (Preprint)
Mobility-Based Smartphone Digital Phenotypes for Unobtrusively Capturing Everyday Cognition, Mood, and Community Life-Space in Older Adults: Feasibility, Acceptability, and Preliminary Validity Study (Preprint) Open
BACKGROUND Current methods of monitoring cognition in older adults are insufficient to address the growing burden of Alzheimer disease and related dementias (AD/ADRD). New approaches that are sensitive, scalable, objective, and reflective…
View article: Psychological, social, and health-related factors predict risk for financial exploitation
Psychological, social, and health-related factors predict risk for financial exploitation Open
People lose tens of billions of dollars a year to financial exploitation in the United States alone. Few studies have examined how preferences for trust and fairness in economic activities may contribute to risk for financial exploitation.…
View article: Psychological, social, and health-related factors predict risk for financial exploitation
Psychological, social, and health-related factors predict risk for financial exploitation Open
Understanding risk factors for financial exploitation (FE) and ways these risk factors may interact is an important step toward identifying vulnerable populations and developing interventions. In three studies, we surveyed 1918 demographic…
View article: 43 Mood and Everyday Function in Older Adults: Analyses of Self-report and Performance-based Measures of Everyday Function
43 Mood and Everyday Function in Older Adults: Analyses of Self-report and Performance-based Measures of Everyday Function Open
Objective: The relation between depressed mood and functional difficulties in older adults has been demonstrated in studies using self-report measures and has been interpreted as evidence for low mood negatively impacting everyday function…
View article: 32 Associations between Childhood Attention Deficit Hyperactivity Disorder and Learning Disabilities and Cognition in Late Adulthood.
32 Associations between Childhood Attention Deficit Hyperactivity Disorder and Learning Disabilities and Cognition in Late Adulthood. Open
Objective: There has been relatively little research on the effect of childhood attention difficulties/weaknesses and learning disabilities/differences on cognitive aging. This study examined associations between self-reported symptoms and…
View article: 85 Evaluating the Improvement on the Naturalistic Action Task After the Virtual Kitchen Intervention: A Case Study
85 Evaluating the Improvement on the Naturalistic Action Task After the Virtual Kitchen Intervention: A Case Study Open
Objective: The goal-control model of the functional impairment in dementia posits two different underlying mechanisms: decay of task goals (reduced task accomplishment) and poor control over goal execution (high error rates). Here we prese…
View article: 64 Validity and Stability of Objective Measures of Subtle Functional Difficulties in Older Adults
64 Validity and Stability of Objective Measures of Subtle Functional Difficulties in Older Adults Open
Objective: Self-reported mild functional difficulties are one of the most salient predictors of future cognitive decline in older adults. However, few measures of objective assessment of mild functional difficulties are available. This stu…
View article: 3 Smartphone Digital Phenotyping for Unobtrusive and Continuous Assessment of Everyday Cognition and Movement Trajectories in Older Adults
3 Smartphone Digital Phenotyping for Unobtrusive and Continuous Assessment of Everyday Cognition and Movement Trajectories in Older Adults Open
Objective: To evaluate the feasibility, usability, and preliminary validity of a digital phenotyping protocol to capture everyday cognition and activities in vivo among older adults. Participants and Methods: Eight participants (M age=69.1…
View article: 50 Examining the Utility of a Performance-Based Test of Everyday Function for Assessing Cognition in Older Adults Who Speak English as a Second Language
50 Examining the Utility of a Performance-Based Test of Everyday Function for Assessing Cognition in Older Adults Who Speak English as a Second Language Open
Objective: Accurate early detection of subtle cognitive difficulties is critical for optimizing treatment of neurodegenerative disease. Those who speak English as a second language (ESL) in the US may be at a disadvantage on Englishwritten…
View article: 57 Financial Literacy in Older Adults: Cognitive, Demographic, and Personality Factors Related to Discrepancies between Objective Financial Knowledge and Subjective Financial Confidence
57 Financial Literacy in Older Adults: Cognitive, Demographic, and Personality Factors Related to Discrepancies between Objective Financial Knowledge and Subjective Financial Confidence Open
Objective: Management of finances is one of the earliest domains of daily living to decline in the neurodegenerative disease process, and poorer financial literacy is associated with worse cognition even in healthy, normative aging. Howeve…
View article: Preliminary data on micro errors as a sensitive measure of everyday functioning in older adults
Preliminary data on micro errors as a sensitive measure of everyday functioning in older adults Open
Background Mild difficulties with daily tasks are associated with cognitive abilities and future cognitive decline but are difficult to measure objectively. Performance‐based tests with high task demands (e.g., multitasking, prospective me…
View article: Capturing Cognitive Aging in Vivo: Application of a Neuropsychological Framework for Emerging Digital Tools
Capturing Cognitive Aging in Vivo: Application of a Neuropsychological Framework for Emerging Digital Tools Open
As the global burden of dementia continues to plague our healthcare systems, efficient, objective, and sensitive tools to detect neurodegenerative disease and capture meaningful changes in everyday cognition are increasingly needed. Emergi…
View article: Age-related differences in ventral striatal and default mode network function during reciprocated trust
Age-related differences in ventral striatal and default mode network function during reciprocated trust Open
Social relationships change across the lifespan as social networks narrow and motivational priorities shift to the present. Interestingly, aging is also associated with changes in executive function, including decision-making abilities, bu…
View article: Sex-Driven Differences in the Effectiveness of Individualized Clinical Management of Alzheimer's Disease Risk
Sex-Driven Differences in the Effectiveness of Individualized Clinical Management of Alzheimer's Disease Risk Open
Individualized multi-domain interventions are equally effective at improving cognition in women and men. However, personally-tailored interventions led to greater improvements in calculated AD and CV risk, and CV blood biomarkers, in women…
View article: Measuring age-related changes in everyday function in vivo: A neuropsychological framework for emerging digital tools (Preprint)
Measuring age-related changes in everyday function in vivo: A neuropsychological framework for emerging digital tools (Preprint) Open
UNSTRUCTURED As the global burden of dementia continues to plague our healthcare system, efficient, objective, and sensitive tools to detect neurodegenerative disease and capture meaningful changes in everyday cognition increasingly are n…