Katherine Malcolm
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0656 Evaluating the Interrelationship Between Insomnia, Sleep Apnea and Nightmares in Veterans With Posttraumatic Stress Disorder Open
Introduction Observational research demonstrates a strong association between nightmares, insomnia, and sleep apnea in veterans with posttraumatic stress disorder (PTSD), supportive of the notion of a “complex sleep disturbance”. Relations…
View article: Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections
Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections Open
Background Antimicrobial resistance (AMR) is rising at an alarming rate and complicating the management of infectious diseases including lower respiratory tract infections (LRTI). Metagenomic next-generation sequencing (mNGS) is a recently…
View article: Additional file 2 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections
Additional file 2 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections Open
Additional file 2: Table S2. mNGS detection of respiratory pathogens compared to a reference standard of clinical microbiological testing.
View article: Additional file 6 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections
Additional file 6 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections Open
Additional file 6: Table S4. AMR genes detected by mNGS.
View article: Additional file 8 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections
Additional file 8 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections Open
Additional file 8: Table S6. Pathogen AMR genes detected by FLASH-mNGS.
View article: Additional file 3 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections
Additional file 3 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections Open
Additional file 3: Dataset 1. AMR gene database utilized for analyses.
View article: Additional file 4 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections
Additional file 4 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections Open
Additional file 4: Dataset 2. AMR genes and guide RNAs for FLASH targeted mNGS. AMR genes and guide RNAs for FLASH targeted mNGS. A) AMR genes targeted by FLASH. B) AMR alleles and guide RNA targets. Legend: Bla = beta lactam; MLS = macrol…
View article: Additional file 5 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections
Additional file 5 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections Open
Additional file 5: Table S3. Time to return of clinical antimicrobial susceptibility testing results for culture-confirmed bacterial pathogens.
View article: Additional file 9 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections
Additional file 9 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections Open
Additional file 9: Table S7. AMR genes detected by FLASH coupled with Nanopore mNGS.
View article: Additional file 7 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections
Additional file 7 of Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections Open
Additional file 7: Table S5. Performance of RNA-seq, DNA-seq and combined RNA-seq + DNA-seq for AMR prediction compared to clinical antimicrobial susceptibility testing.
View article: Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19
Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19 Open
National Center for Advancing Translational Sciences, National Heart Lung Blood Institute, National Institute of Allergy and Infectious Diseases, Chan Zuckerberg Biohub, Chan Zuckerberg Initiative.
View article: Management and Outcomes of Critically-Ill Patients with COVID-19 Pneumonia at a Safety-net Hospital in San Francisco, a Region with Early Public Health Interventions: A Case Series
Management and Outcomes of Critically-Ill Patients with COVID-19 Pneumonia at a Safety-net Hospital in San Francisco, a Region with Early Public Health Interventions: A Case Series Open
Background Following early implementation of public health measures, San Francisco has experienced a slow rise and a low peak level of coronavirus disease 2019 (COVID-19) cases and deaths. Methods and Findings We included all patients with…
View article: Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: a comparison of patients with and without COVID-19
Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: a comparison of patients with and without COVID-19 Open
Background Emerging data on the clinical presentation, diagnostics, and outcomes of patients with COVID-19 have largely been presented as case series. Few studies have compared these clinical features and outcomes of COVID-19 to other acut…
Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults Open
Lower respiratory tract infections (LRTIs) lead to more deaths each year than any other infectious disease category. Despite this, etiologic LRTI pathogens are infrequently identified due to limitations of existing microbiologic tests. In …
Integrating Host Response and Unbiased Microbe Detection for Lower Respiratory Tract Infection Diagnosis in Critically Ill Adults Open
Lower respiratory tract infections (LRTI) lead to more deaths each year than any other infectious disease category. Despite this, etiologic LRTI pathogens are infrequently identified due to limitations of existing microbiologic tests. In c…
Integrating Host Response and Unbiased Microbe Detection for Lower Respiratory Tract Infection Diagnosis in Critically Ill Adults Open
Lower respiratory tract infections (LRTI) lead to more deaths each year than any other infectious disease category(1). Despite this, etiologic LRTI pathogens are infrequently identified due to limitations of existing microbiologic tests(2)…
Implementing prevention programs to limit cyber-bullying in junior and intermediate grades Open
In this study I explore the benefits of current proactive cyber-bullying prevention programming used in elementary educational communities. In recent years cyber-bullying has become a new phenomenon due to quickly advancing digital world w…