Rachel K. Scott
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View article: Off‐label dosing of long‐acting injectable cabotegravir and rilpivirine during pregnancy: A case study with therapeutic drug monitoring
Off‐label dosing of long‐acting injectable cabotegravir and rilpivirine during pregnancy: A case study with therapeutic drug monitoring Open
We report individualized off‐label monthly use of a high dose of long‐acting intramuscular cabotegravir/rilpivirine (CAB/RPV = 600 mg/900 mg) co‐administered preconceptionally and throughout pregnancy with subcutaneous lenacapavir to a you…
View article: Development of a Semi-Mechanistic Population Pharmacokinetic Model for Predicting Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide Exposure in Plasma and Cellular Matrices During Pregnancy and Postpartum
Development of a Semi-Mechanistic Population Pharmacokinetic Model for Predicting Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide Exposure in Plasma and Cellular Matrices During Pregnancy and Postpartum Open
Our semi-mechanistic model provides a framework for understanding pregnancy-associated pharmacokinetic changes and supports future research to refine dosing strategies for HIV treatment and prevention in pregnancy.
View article: Serum soluble fms-like tyrosine kinase kinase 1-to-placental growth factor ratio on Elecsys immunoassay platform predicts preeclampsia with severe features in hospitalized women with hypertensive disorders of pregnancy
Serum soluble fms-like tyrosine kinase kinase 1-to-placental growth factor ratio on Elecsys immunoassay platform predicts preeclampsia with severe features in hospitalized women with hypertensive disorders of pregnancy Open
The soluble fms-like tyrosine kinase 1-to-placental growth factor ratio of >38 measured on the Elecsys platform predicted the development of preeclampsia with severe features, delivery, and adverse maternal and fetal/neonatal outcomes with…
View article: Development of a Clinic-Based, Sociostructural Intervention to Improve the Provision of Pre-Exposure Prophylaxis for Cisgender Women: Formative Study Using the Assessment, Decision, Adaptation, Production, Topical Experts, Integration, Training, and Testing (ADAPT-ITT) Framework
Development of a Clinic-Based, Sociostructural Intervention to Improve the Provision of Pre-Exposure Prophylaxis for Cisgender Women: Formative Study Using the Assessment, Decision, Adaptation, Production, Topical Experts, Integration, Training, and Testing (ADAPT-ITT) Framework Open
Background Cisgender women (subsequently referred to as women) account for 23% of new HIV diagnoses in the United States. There are significant sociostructural barriers to engagement and retention in the pre-exposure prophylaxis (PrEP) cas…
View article: Development and Pilot Evaluation of an Educational Postpartum Contraception Video
Development and Pilot Evaluation of an Educational Postpartum Contraception Video Open
OBJECTIVE: To investigate the acceptability, feasibility, and efficacy of a novel video–based intervention designed for postpartum contraceptive education. METHODS: The research team created and field-tested the prototype for an educationa…
View article: Development of a Clinic-Based, Sociostructural Intervention to Improve the Provision of Pre-Exposure Prophylaxis for Cisgender Women: Formative Study Using the Assessment, Decision, Adaptation, Production, Topical Experts, Integration, Training, and Testing (ADAPT-ITT) Framework (Preprint)
Development of a Clinic-Based, Sociostructural Intervention to Improve the Provision of Pre-Exposure Prophylaxis for Cisgender Women: Formative Study Using the Assessment, Decision, Adaptation, Production, Topical Experts, Integration, Training, and Testing (ADAPT-ITT) Framework (Preprint) Open
BACKGROUND Cisgender women (subsequently referred to as women) account for 23% of new HIV diagnoses in the United States. There are significant sociostructural barriers to engagement and retention in the pre-exposure prophylaxis (PrEP) ca…
View article: P-1415. Social Determinants of Health and Side Effects Significantly Predict Pre-Exposure Prophylaxis (PrEP) Preferences for Every 2 Month Long-Acting Injectable vs. Daily Oral PrEP among Cisgender Women in the United States and the Dominican Republic
P-1415. Social Determinants of Health and Side Effects Significantly Predict Pre-Exposure Prophylaxis (PrEP) Preferences for Every 2 Month Long-Acting Injectable vs. Daily Oral PrEP among Cisgender Women in the United States and the Dominican Republic Open
Background Significant HIV inequities exist among cisgender women (CGW) across settings. Black CGW in the United States (US) have an HIV diagnosis rate 10.8 times greater than White CGW. Female sex workers (FSW) have 30-times increased odd…
View article: P-1401. Association Between Intimate Partner Violence and Antiretroviral Adherence Among Pregnant Women Living with HIV
P-1401. Association Between Intimate Partner Violence and Antiretroviral Adherence Among Pregnant Women Living with HIV Open
Background Despite increased access to antiretroviral therapy (ART) for women with HIV (WWH), challenges like unaddressed mental health issues and poor postpartum HIV care retention persist. This analysis evaluates whether Intimate Partner…
View article: P-500. Awareness and preferences for every 2 month long-acting injectable HIV Pre-Exposure Prophylaxis (PrEP) versus daily oral PrEP among cisgender women in the United States and the Dominican Republic
P-500. Awareness and preferences for every 2 month long-acting injectable HIV Pre-Exposure Prophylaxis (PrEP) versus daily oral PrEP among cisgender women in the United States and the Dominican Republic Open
Background Globally, cisgender women (CGW) represent 53% of people with HIV and 45% of new acquisitions (2022). Female sex workers (FSW) are 30 times more likely to acquire HIV (vs women overall); in the US 54% of new diagnoses in CGW are …
View article: Age-related factors associated with intention to initiate pre-exposure prophylaxis among cisgender women in Washington D.C.
Age-related factors associated with intention to initiate pre-exposure prophylaxis among cisgender women in Washington D.C. Open
Background: Pre-exposure prophylaxis (PrEP) utilization among cisgender women (subsequently ‘women’) is low across age groups, relative to their risk of HIV acquisition. We hypothesize that age-related differences in psychosocial factors a…
View article: 1843. Exploring Cisgender Women's HIV Pre-Exposure Prophylaxis (PrEP) Needs and Preferences Across Settings: the Roles of Social-Structural Factors
1843. Exploring Cisgender Women's HIV Pre-Exposure Prophylaxis (PrEP) Needs and Preferences Across Settings: the Roles of Social-Structural Factors Open
Background Cisgender women (CGW) account for 48% of new HIV infections globally and 18% of new HIV infections in the United States (US) but comprise only 8% of daily oral PrEP users in the US. Social-structural factors including stigma, ge…
View article: Clinical trial simulation to evaluate tenofovir disoproxil fumarate/emtricitabine HIV pre-exposure prophylaxis dosing during pregnancy
Clinical trial simulation to evaluate tenofovir disoproxil fumarate/emtricitabine HIV pre-exposure prophylaxis dosing during pregnancy Open
Objective To evaluate upward-adjustment of tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) pre-exposure prophylaxis (PrEP) dosing during pregnancy in order to maintain target plasma concentrations associated with HIV protection. De…
View article: Implementation of an Educational Intervention to Improve HIV Pre-Exposure Prophylaxis Services for Women in an Urban Sexual Health Clinic
Implementation of an Educational Intervention to Improve HIV Pre-Exposure Prophylaxis Services for Women in an Urban Sexual Health Clinic Open
To test the hypothesis that implementation of a multicomponent, educational HIV pre-exposure prophylaxis (PrEP) intervention to promote universal PrEP services for cisgender women (subsequently "women") in sexual and reproductive health ce…
View article: Translating Clinical Pharmacology Data in Pregnancy to Evidence‐Based Guideline Recommendations: Perspectives From the HIV Field
Translating Clinical Pharmacology Data in Pregnancy to Evidence‐Based Guideline Recommendations: Perspectives From the HIV Field Open
Pharmacokinetic (PK) studies in pregnant, postpartum, and breastfeeding people are critical to informing appropriate medication use and dosing. A key component of translating PK results in these complex populations into clinical practice i…
View article: The end of Roe v. Wade: implications for Women’s mental health and care
The end of Roe v. Wade: implications for Women’s mental health and care Open
The Supreme Court decision in Dobbs v. Jackson in June 2022 reversed precedent which had previously protected abortion prior to fetal viability as a universal right within the United States. This decision almost immediately led to abortion…
View article: Understanding Retention in the HIV Pre-Exposure Prophylaxis Cascade Among Cisgender Women
Understanding Retention in the HIV Pre-Exposure Prophylaxis Cascade Among Cisgender Women Open
HIV remains a significant public health concern in the United States, with 34,800 new cases diagnosed in 2019; of those, 18% were among women. Oral pre-exposure prophylaxis (PrEP) with daily tenofovir disoproxil fumarate/emtricitabine is e…
View article: Understanding Psychosocial Determinants of PrEP Uptake Among Cisgender Women Experiencing Heightened HIV Risk: Implications for Multi-Level Communication Intervention
Understanding Psychosocial Determinants of PrEP Uptake Among Cisgender Women Experiencing Heightened HIV Risk: Implications for Multi-Level Communication Intervention Open
Pre-exposure prophylaxis (PrEP) is a highly effective daily pill that decreases the likelihood of HIV acquisition by up to 92% among individuals at risk for HIV. PrEP can be discretely used, autonomously controlled, and in place at the tim…
View article: Integrating ART Adherence Support Technologies in the Care of Pregnant and Postpartum Women With HIV: A Qualitative Study
Integrating ART Adherence Support Technologies in the Care of Pregnant and Postpartum Women With HIV: A Qualitative Study Open
Background: We have a limited understanding on how to best integrate technologies to support antiretroviral therapy (ART) adherence in routine HIV care. Methods: We conducted semi-structured interviews with multidisciplinary providers cari…
View article: Providers PrEP: Identifying Primary Health care Providers' Biases as Barriers to Provision of Equitable PrEP Services
Providers PrEP: Identifying Primary Health care Providers' Biases as Barriers to Provision of Equitable PrEP Services Open
Background: Despite their disparately high HIV incidence and voiced willingness to use pre-exposure prophylaxis (PrEP), Black cisgender women's knowledge and uptake of PrEP are low, especially relative to White cisgender women and men who …
View article: Awareness, acceptability, and intention to initiate HIV pre-exposure prophylaxis among pregnant women
Awareness, acceptability, and intention to initiate HIV pre-exposure prophylaxis among pregnant women Open
HIV prevention is critically important during pregnancy, however, pre-exposure prophylaxis (PrEP) is underutilized. We conducted a survey of pregnant and non-pregnant women in a high HIV prevalence community in Washington D.C. to evaluate …
View article: Advance Care Planning—Complex and Working: Longitudinal Trajectory of Congruence in End-of-Life Treatment Preferences: An RCT
Advance Care Planning—Complex and Working: Longitudinal Trajectory of Congruence in End-of-Life Treatment Preferences: An RCT Open
Context: The effect of advance care planning (ACP) interventions on the trajectory of end-of-life treatment preference congruence between patients and surrogate decision-makers is unstudied. Objective: To identify unobserved distinctive pa…