Katheryn EA Hazel
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View article: High‐throughput CRISPR screen of GWAS risk loci in human microglia reveals novel risk genes for Alzheimer's disease and multiple sclerosis
High‐throughput CRISPR screen of GWAS risk loci in human microglia reveals novel risk genes for Alzheimer's disease and multiple sclerosis Open
Background Alzheimer's (AD) and other neurological diseases (NDs) cause substantial health‐related and economic burdens, but progress toward preventative or ameliorative treatments has been limited. Genome‐wide association studies (GWAS) h…
View article: Epigenomics and single cell CRISPR screening to investigate the risk‐modifying role of microglia in Alzheimer’s disease and multiple sclerosis
Epigenomics and single cell CRISPR screening to investigate the risk‐modifying role of microglia in Alzheimer’s disease and multiple sclerosis Open
Background Alzheimer’s disease (AD) and other neurodegenerative diseases (NDs) cause substantial health‐related and economic burdens, but progress towards preventative or ameliorative treatments has been limited. Genome‐wide association st…
View article: High‐throughput CRISPRi screening to investigate mechanisms underlying Alzheimer’s risk loci
High‐throughput CRISPRi screening to investigate mechanisms underlying Alzheimer’s risk loci Open
Background Alzheimer’s disease (AD) is a highly (60‐80%) heritable disease with 75 known genetic risk loci. Interestingly, preliminary data from human tissues suggests that these risk loci predominantly act through myeloid cells, implicati…