Kathinka E. Pitman
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View article: The Role of TGF-β3 in Radiation Response
The Role of TGF-β3 in Radiation Response Open
Transforming growth factor-beta 3 (TGF-β3) is a ubiquitously expressed multifunctional cytokine involved in a range of physiological and pathological conditions, including embryogenesis, cell cycle regulation, immunoregulation, and fibroge…
View article: Low-Dose-Rate Radiation-Induced Secretion of TGF-β3 Together with an Activator in Small Extracellular Vesicles Modifies Low-Dose Hyper-Radiosensitivity through ALK1 Binding
Low-Dose-Rate Radiation-Induced Secretion of TGF-β3 Together with an Activator in Small Extracellular Vesicles Modifies Low-Dose Hyper-Radiosensitivity through ALK1 Binding Open
Hyper-radiosensitivity (HRS) is the increased sensitivity to low doses of ionizing radiation observed in most cell lines. We previously demonstrated that HRS is permanently abolished in cells irradiated at a low dose rate (LDR), in a mecha…
View article: Low Dose Rate Radiation Induced Secretion of TGF-β3 Together With an Activator in Small Extracellular Vesicles Modifies Low Dose Hyper-Radiosensitivity Through ALK1 Binding
Low Dose Rate Radiation Induced Secretion of TGF-β3 Together With an Activator in Small Extracellular Vesicles Modifies Low Dose Hyper-Radiosensitivity Through ALK1 Binding Open
Hyper-radiosensitivity (HRS) is the increased sensitivity to low doses of ionizing radiation observed in most cell lines. We previously demonstrated that HRS is permanently abolished in cells irradiated at a low dose rate (LDR), in a mecha…
View article: Ultra-early changes in vascular parameters from dynamic contrast enhanced MRI of breast cancer xenografts following systemic therapy with doxorubicin and liver X receptor agonist
Ultra-early changes in vascular parameters from dynamic contrast enhanced MRI of breast cancer xenografts following systemic therapy with doxorubicin and liver X receptor agonist Open
Background Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) may be used to depict tumour vascular structure and for therapy response assessment in various tumour sites. The purpose of the current work is to examine whether ul…
View article: Synthesis, radiosynthesis, and positron emission tomography neuroimaging using 5‐[<sup>18</sup>F]fluoro‐L‐amino suberate
Synthesis, radiosynthesis, and positron emission tomography neuroimaging using 5‐[<sup>18</sup>F]fluoro‐L‐amino suberate Open
System xc‐ (Sx c ‐) has emerged as a new biological target for PET studies to detect oxidative and excitotoxic stress. Notably, applications have, thus far, been limited to tumour imaging although Sx c ‐ ) may play a major role in neurodeg…
View article: Variability of dynamic 18F-FDG-PET data in breast cancer xenografts
Variability of dynamic 18F-FDG-PET data in breast cancer xenografts Open
SUVmean and SUVmedian show less variability than SUVmax. The pharmacokinetic tumour metrics again display much greater variability than the SUV-based metrics. However, it is generally not known which of these metrics that best represents c…
View article: EP-1183: Inter- and intra-variability of dynamic FDG-PET data in breast cancer xenografts
EP-1183: Inter- and intra-variability of dynamic FDG-PET data in breast cancer xenografts Open